From Biology to Treatment of Monoclonal Gammopathies of Neurological Significance.
Castleman’s disease
POEMS syndrome
anti-myelin-associated-glycoprotein (MAG) polyneuropathy
ibrutinib
monoclonal gammopathies of neurological significance (MGNS)
rituximab
venetoclax
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
18 Mar 2022
18 Mar 2022
Historique:
received:
08
02
2022
revised:
06
03
2022
accepted:
15
03
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
26
3
2022
Statut:
epublish
Résumé
Monoclonal gammopathy and peripheral neuropathy are common diseases of elderly patients, and almost 10% of patients with neuropathy of unknown cause have paraprotein. However, growing evidence suggests that several hematological malignancies synthesize and release monoclonal proteins that damage the peripheral nervous system through different mechanisms. The spectrum of the disease varies from mild to rapidly progressive symptoms, sometimes affecting not only sensory nerve fibers, but also motor and autonomic fibers. Therefore, a multidisciplinary approach, mainly between hematologists and neurologists, is recommended in order to establish the correct diagnosis of monoclonal gammopathy of neurological significance and to tailor therapy based on specific genetic mutations. In this review, we summarize the spectrum of monoclonal gammopathies of neurological significance, their distinctive clinical and neurophysiological phenotypes, the most relevant pathophysiological events and new therapeutic approaches.
Identifiants
pubmed: 35326711
pii: cancers14061562
doi: 10.3390/cancers14061562
pmc: PMC8946535
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Italian Association for Cancer Research
ID : IG-25024
Organisme : Ricerca per Credere nella Vita RCV odv
ID : grant to LT
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