PI3K Inhibitors for the Treatment of Chronic Lymphocytic Leukemia: Current Status and Future Perspectives.
BGB-10188
PI3-kinase inhibitors
chronic lymphocytic leukemia
copanlisib
duvelisib
idelalisib
parsaclisib
safety
treatment
umbralisib
zandelisib
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
18 Mar 2022
18 Mar 2022
Historique:
received:
17
02
2022
revised:
16
03
2022
accepted:
17
03
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
26
3
2022
Statut:
epublish
Résumé
Phosphoinositide 3-kinases (PI3Ks) signaling regulates key cellular processes, such as growth, survival and apoptosis. Among the three classes of PI3K, class I is the most important for the development, differentiation and activation of B and T cells. Four isoforms are distinguished within class I (PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ). PI3Kδ expression is limited mainly to the B cells and their precursors, and blocking PI3K has been found to promote apoptosis of chronic lymphocytic leukemia (CLL) cells. Idelalisib, a selective PI3Kδ inhibitor, was the first-in-class PI3Ki introduced into CLL treatment. It showed efficacy in patients with del(17p)/
Identifiants
pubmed: 35326722
pii: cancers14061571
doi: 10.3390/cancers14061571
pmc: PMC8945984
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Medical University of Lodz
ID : 503/1-093-01/503-11-004-18
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