Adrenomedullin Therapy in Moderate to Severe COVID-19.
COVID-19
acute respiratory distress syndrome
adrenomedullin
clinical trial
pneumonia
translational study
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
24 Feb 2022
24 Feb 2022
Historique:
received:
04
02
2022
revised:
19
02
2022
accepted:
21
02
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
26
3
2022
Statut:
epublish
Résumé
The 2019 coronavirus (COVID-19) pandemic is still in progress, and a significant number of patients have presented with severe illness. Recently introduced vaccines, antiviral medicines, and antibody formulations can suppress COVID-19 symptoms and decrease the number of patients exhibiting severe disease. However, complete avoidance of severe COVID-19 has not been achieved, and more importantly, there are insufficient methods to treat it. Adrenomedullin (AM) is an endogenous peptide that maintains vascular tone and endothelial barrier function. The AM plasma level is markedly increased during severe inflammatory disorders, such as sepsis, pneumonia, and COVID-19, and is associated with the severity of inflammation and its prognosis. In this study, exogenous AM administration reduced inflammation and related organ damage in rodent models. The results of this study strongly suggest that AM could be an alternative therapy in severe inflammation disorders, including COVID-19. We have previously developed an AM formulation to treat inflammatory bowel disease and are currently conducting an investigator-initiated phase 2a trial for moderate to severe COVID-19 using the same formulation. This review presents the basal AM information and the most recent translational AM/COVID-19 study.
Identifiants
pubmed: 35327335
pii: biomedicines10030533
doi: 10.3390/biomedicines10030533
pmc: PMC8945653
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Japan Agency for Medical Research and Development
ID : 20fk0108275h0001, 20fk0108504h0001
Références
Drug Des Devel Ther. 2020 Jan 06;14:1-11
pubmed: 32021087
Clin Chem Lab Med. 2016 Jan;54(1):163-8
pubmed: 26083268
N Engl J Med. 2021 Mar 4;384(9):795-807
pubmed: 33306283
Crit Care. 2020 Jul 9;24(1):411
pubmed: 32646523
Int J Infect Dis. 2021 Oct;111:211-218
pubmed: 34461254
Ann Intensive Care. 2017 Dec;7(1):15
pubmed: 28185230
N Engl J Med. 2021 Feb 25;384(8):693-704
pubmed: 32678530
J Mol Cell Cardiol. 2022 Mar;164:69-82
pubmed: 34838588
Crit Care Med. 2021 Dec 1;49(12):2112-2120
pubmed: 34582409
J Crit Care. 2021 Dec;66:173-180
pubmed: 34340901
Biochem Biophys Res Commun. 1993 Apr 30;192(2):553-60
pubmed: 8387282
Minerva Anestesiol. 2021 Oct;87(10):1117-1127
pubmed: 34134460
Pol J Pharmacol. 2004 Jan-Feb;56(1):5-27
pubmed: 15047974
J Cardiovasc Pharmacol. 2002 May;39(5):754-60
pubmed: 11973420
BMJ. 2020 Sep 4;370:m3379
pubmed: 32887691
Shock. 2018 Dec;50(6):648-654
pubmed: 29324627
Cureus. 2020 Oct 12;12(10):e10906
pubmed: 33194473
N Engl J Med. 2021 Jan 21;384(3):229-237
pubmed: 33113295
J Gastroenterol. 2021 Feb;56(2):147-157
pubmed: 33140199
Lancet. 2020 May 2;395(10234):1417-1418
pubmed: 32325026
Lancet. 2021 May 01;397(10285):1637-1645
pubmed: 33933206
Eur Respir Rev. 2021 Dec 15;30(162):
pubmed: 34911695
Blood Rev. 2021 May;47:100761
pubmed: 33067035
J Immunol. 2007 Nov 1;179(9):6263-72
pubmed: 17947702
Aust Crit Care. 2021 Mar;34(2):167-175
pubmed: 33250401
Clin Chem Lab Med. 2021 Jan 08;59(5):995-1004
pubmed: 33554516
N Engl J Med. 2022 Feb 3;386(5):494-496
pubmed: 34965358
Infect Dis Ther. 2022 Feb;11(1):231-248
pubmed: 34757578
Peptides. 2005 Dec;26(12):2610-5
pubmed: 15978699
Am J Emerg Med. 2013 Jul;31(7):1017-21
pubmed: 23688561
Rev Med Virol. 2022 Mar;32(2):e2277
pubmed: 34286893
N Engl J Med. 2021 Apr 15;384(15):1412-1423
pubmed: 33626250
Thromb Haemost. 2007 Nov;98(5):944-51
pubmed: 18000597
N Engl J Med. 2022 Feb 10;386(6):509-520
pubmed: 34914868
PLoS One. 2021 Feb 8;16(2):e0246771
pubmed: 33556140
Mol Cell Biol. 2006 Apr;26(7):2511-8
pubmed: 16537897
Circulation. 2001 Oct 16;104(16):1964-71
pubmed: 11602502
Chest. 2017 Aug;152(2):312-320
pubmed: 28411114
Peptides. 2020 Sep;131:170347
pubmed: 32569606
Intensive Care Med. 2007 Apr;33(4):703-10
pubmed: 17318497
Dig Dis Sci. 2016 Mar;61(3):872-80
pubmed: 26470867
Am J Physiol Heart Circ Physiol. 2000 Dec;279(6):H2620-6
pubmed: 11087213
J Med Virol. 2021 May;93(5):2820-2827
pubmed: 33200824
Ann Surg. 2002 Nov;236(5):625-33
pubmed: 12409669
Lancet Respir Med. 2021 Dec;9(12):1407-1418
pubmed: 34480861
Microb Pathog. 2019 Dec;137:103763
pubmed: 31574301
Regul Pept. 2003 Apr 15;112(1-3):61-9
pubmed: 12667626
Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):615-9
pubmed: 11149956
Eur J Clin Invest. 2021 May;51(5):e13511
pubmed: 33569769
BJS Open. 2020 Jun;4(3):524-534
pubmed: 32073224
Peptides. 2007 Nov;28(11):2164-70
pubmed: 17889965
Crit Care. 2018 Dec 21;22(1):354
pubmed: 30583748
Diabetes Metab Syndr. 2022 Feb;16(2):102396
pubmed: 35051686
Crit Care. 2014 Apr 14;18(2):R73
pubmed: 24731244
Clin Chim Acta. 2021 Dec;523:185-190
pubmed: 34555411
Crit Care. 2014 Feb 17;18(1):R34
pubmed: 24533868
Intensive Care Med. 2021 Nov;47(11):1284-1294
pubmed: 34605947
J Clin Endocrinol Metab. 1997 Jan;82(1):95-100
pubmed: 8989240
J Clin Invest. 2019 Jun 17;129(7):2775-2791
pubmed: 31205027
Shock. 2020 Dec;54(6):810-818
pubmed: 32554994
Crit Care. 2018 Mar 21;22(1):79
pubmed: 29562917
Crit Care. 2005;9(6):R816-24
pubmed: 16356231
Surgery. 2007 Feb;141(2):245-53
pubmed: 17263982
APMIS. 2012 Sep;120(9):706-11
pubmed: 22882259
Crit Rev Neurobiol. 1997;11(2-3):167-239
pubmed: 9209829
Eur Rev Med Pharmacol Sci. 2021 Feb;25(3):1743-1751
pubmed: 33629344
Sci Rep. 2020 Oct 6;10(1):16605
pubmed: 33024218
Intern Med. 2019 Jun 1;58(11):1573-1576
pubmed: 30713309
Sci Rep. 2021 Mar 4;11(1):5121
pubmed: 33664308
Microbiol Immunol. 2009 Oct;53(10):573-81
pubmed: 19780971
Peptides. 2004 Aug;25(8):1369-72
pubmed: 15350706
Cell Tissue Res. 2014 Mar;355(3):657-73
pubmed: 24599335
Biochem Biophys Res Commun. 1998 Mar 17;244(2):551-5
pubmed: 9514956
Int J Clin Pract. 2021 Nov;75(11):e14843
pubmed: 34519155
Mol Med. 2009 Jan-Feb;15(1-2):28-33
pubmed: 19009024
Circulation. 2005 May 24;111(20):2605-10
pubmed: 15897343
Lab Med. 2021 Sep 1;52(5):493-498
pubmed: 33928380
Circulation. 2000 May 16;101(19):2309-16
pubmed: 10811600
Br J Anaesth. 2007 Dec;99(6):830-6
pubmed: 17962242
Blood. 2022 Jan 05;:
pubmed: 34986238
J Clin Med. 2021 Apr 13;10(8):
pubmed: 33924637
Intensive Care Med. 2009 Nov;35(11):1859-67
pubmed: 19662382
Intensive Care Med Exp. 2019 May 15;7(1):25
pubmed: 31093784
Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G43-51
pubmed: 19423749
J Mol Cell Cardiol. 2014 Dec;77:73-85
pubmed: 25264174
Biomarkers. 2021 Jul;26(5):417-424
pubmed: 33754916
BMJ. 2021 Nov 8;375:n2713
pubmed: 34750163
Shock. 2016 Mar;45(3):259-70
pubmed: 26871664
Crit Care Med. 2005 Apr;33(4):819-26
pubmed: 15818111
J Am Coll Surg. 2007 Aug;205(2):284-93
pubmed: 17660075
Lancet Respir Med. 2022 Mar;10(3):247-254
pubmed: 34895483
Crit Care. 2020 Aug 28;24(1):527
pubmed: 32859259
Infect Dis Ther. 2021 Dec;10(4):2479-2488
pubmed: 34435337
Infect Dis Model. 2022 Mar;7(1):62-81
pubmed: 34869959
Infect Immun. 1998 Oct;66(10):4669-75
pubmed: 9746563
N Engl J Med. 2021 Oct 7;385(15):1382-1392
pubmed: 34260849
N Engl J Med. 2021 Mar 11;384(10):905-914
pubmed: 33356051
Curr Probl Cardiol. 2021 Mar;46(3):100742
pubmed: 33243440
Br J Clin Pharmacol. 2018 Sep;84(9):2129-2141
pubmed: 29856470
Shock. 2017 Oct;48(4):418-426
pubmed: 28414691
FEBS Lett. 2004 Jan 2;556(1-3):53-8
pubmed: 14706825
Lancet Respir Med. 2022 Feb;10(2):214-220
pubmed: 34838161
Int J Hematol. 2021 Jan;113(1):45-57
pubmed: 33161508
Hypertens Res. 2022 Mar;45(3):389-400
pubmed: 34992239
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Circ Res. 2002 Oct 4;91(7):618-25
pubmed: 12364390
Hypertens Res. 2010 Apr;33(4):314-9
pubmed: 20094056
Front Immunol. 2018 Feb 19;9:292
pubmed: 29520277
N Engl J Med. 2020 Dec 31;383(27):2603-2615
pubmed: 33301246
Inflamm Bowel Dis. 2013 Feb;19(2):E26-7
pubmed: 22294498
Hypertens Res. 2010 Apr;33(4):374-9
pubmed: 20150911
Biomolecules. 2020 Aug 11;10(8):
pubmed: 32796765
Curr Protein Pept Sci. 2013 Aug;14(5):347-57
pubmed: 23745699
Peptides. 2010 May;31(5):872-7
pubmed: 20132852