Influence of Fetomaternal Microchimerism on Maternal NK Cell Reactivity against the Child's Leukemic Blasts.
HLA
KIR
NK cell alloreactivity
fetal microchimerism
haploidentical stem cell transplantation
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
04 Mar 2022
04 Mar 2022
Historique:
received:
04
02
2022
revised:
28
02
2022
accepted:
02
03
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
26
3
2022
Statut:
epublish
Résumé
Persistence of fetal cells in the circulation of the mother (fetal microchimerism, FM) is associated with increased survival and reduced relapse of children with leukemia receiving a haploidentical hematopoietic stem cell transplantation (hHSCT). NK cells play an important role in maternal tolerance towards the unborn child. In this study, 70 mother-child pairs were prospectively analyzed for the occurrence of FM, KIR genotype and HLA-C type. We found that occurrence and level of FM were influenced by three maternal genetic factors: presence of an HLA-C1 allele, absence of KIR2DL3 and presence of a cen-B/B motif. Furthermore, an HLA-C match between mother and child favored persistence of FM. NK cells from FM
Identifiants
pubmed: 35327405
pii: biomedicines10030603
doi: 10.3390/biomedicines10030603
pmc: PMC8945103
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Else Kröner-Fresenius-Stiftung
ID : 2015_A35
Organisme : Fördergemeinschaft Kinderkrebs-Zentrum Hamburg
ID : Scholarship L.-M. Martin
Références
Hum Reprod. 2008 Apr;23(4):972-6
pubmed: 18263639
Eur J Immunol. 1997 Apr;27(4):979-83
pubmed: 9130653
Ann N Y Acad Sci. 2004 Jun;1022:113-8
pubmed: 15251948
J Exp Med. 2004 Oct 18;200(8):957-65
pubmed: 15477349
Nature. 1979 Jan 18;277(5693):221-3
pubmed: 95205
Hum Immunol. 2012 Jan;73(1):80-92
pubmed: 22074999
PLoS One. 2010 Dec 29;5(12):e15115
pubmed: 21206914
J Immunol Methods. 1998 Sep 1;218(1-2):155-60
pubmed: 9819132
Blood. 2008 Oct 1;112(7):2990-5
pubmed: 18492955
Biol Blood Marrow Transplant. 2014 Jan;20(1):98-105
pubmed: 24516895
Exp Hematol. 2015 Jun;43(6):462-8.e1
pubmed: 25795523
Nat Rev Immunol. 2002 Sep;2(9):656-63
pubmed: 12209134
Bone Marrow Transplant. 2021 Aug;56(8):1900-1907
pubmed: 33767404
Blood. 2011 Dec 1;118(23):6006-17
pubmed: 21921045
Immunol Today. 1990 Jul;11(7):237-44
pubmed: 2201309
Mucosal Immunol. 2022 Jan;15(1):120-129
pubmed: 34552206
Immun Inflamm Dis. 2017 Dec;5(4):461-468
pubmed: 28685972
J Clin Invest. 2007 May;117(5):1399-411
pubmed: 17446933
Annu Rev Immunol. 2001;19:291-330
pubmed: 11244039
Blood Cells Mol Dis. 2008 Jan-Feb;40(1):84-90
pubmed: 17964828
Blood. 2010 Oct 7;116(14):2411-9
pubmed: 20581313
Clin Chem. 2000 Sep;46(9):1301-9
pubmed: 10973858
Front Immunol. 2019 May 28;10:1179
pubmed: 31231370
Am J Epidemiol. 2000 Jan 1;151(1):57-62
pubmed: 10625174
Hum Reprod. 2008 Nov;23(11):2535-48
pubmed: 18658158
Blood. 2009 Jan 15;113(3):726-32
pubmed: 18945962
Bone Marrow Transplant. 2019 Aug;54(Suppl 2):743-748
pubmed: 31431703
Science. 2002 Mar 15;295(5562):2097-100
pubmed: 11896281
Nature. 1986 Feb 20-26;319(6055):675-8
pubmed: 3951539
Int J Cancer. 1975 Aug 15;16(2):216-29
pubmed: 50294
Blood. 1999 Jul 1;94(1):333-9
pubmed: 10381530
J Immunol. 2016 Dec 1;197(11):4292-4300
pubmed: 27815424
Blood. 2014 Aug 7;124(6):843-50
pubmed: 24916508
Blood. 2014 Oct 23;124(17):2744-7
pubmed: 25115891
Reprod Biomed Online. 2016 Dec;33(6):763-769
pubmed: 27751789
J Immunol. 2014 Jun 1;192(11):4949-56
pubmed: 24837152
Immunity. 1997 Dec;7(6):753-63
pubmed: 9430221
J Immunol. 2014 Jun 1;192(11):5069-73
pubmed: 24778445
Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):845-50
pubmed: 25561558
Nature. 2012 Oct 4;490(7418):102-6
pubmed: 23023128
Br J Haematol. 2006 Jul;134(2):196-201
pubmed: 16846478
Immunogenetics. 2002 Jul;54(4):221-9
pubmed: 12136333
J Clin Invest. 2010 Nov;120(11):4102-10
pubmed: 20972337
J Hematother Stem Cell Res. 2001 Jun;10(3):419-25
pubmed: 11454317
Bone Marrow Transplant. 2015 Oct;50(10):1367-70
pubmed: 26098953
Transplant Cell Ther. 2022 Jan 10;:
pubmed: 35017118
Cell Mol Immunol. 2017 Apr;14(4):321-330
pubmed: 27264685
Nat Med. 2006 Sep;12(9):1065-74
pubmed: 16892062
Blood. 2002 Jun 15;99(12):4618-25
pubmed: 12036896
Nat Rev Immunol. 2013 Feb;13(2):133-44
pubmed: 23334245
Gene. 2004 Jun 23;335:121-31
pubmed: 15194195
Bone Marrow Transplant. 2019 Nov;54(11):1847-1858
pubmed: 31089287
Curr Opin Hematol. 2012 Jul;19(4):324-35
pubmed: 22517587
Tissue Antigens. 2009 Feb;73(2):188-91
pubmed: 19140829
Eur J Immunol. 1975 Feb;5(2):112-7
pubmed: 1234049
Cancers (Basel). 2020 Aug 05;12(8):
pubmed: 32764469
Clin Exp Immunol. 2004 May;136(2):373-8
pubmed: 15086404