Plasma Metabolomic Profiling Reveals Four Possibly Disrupted Mechanisms in Systemic Sclerosis.
LC-MS/MS
gut dysbiosis
ion mobility
kynurenine pathway
lipids
metabolomics
systemic sclerosis
urea cycle
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
04 Mar 2022
04 Mar 2022
Historique:
received:
31
12
2021
revised:
24
02
2022
accepted:
26
02
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
26
3
2022
Statut:
epublish
Résumé
Systemic sclerosis (SSc) is a rare systemic autoimmune disorder marked by high morbidity and increased risk of mortality. Our study aimed to analyze metabolomic profiles of plasma from SSc patients by using targeted and untargeted metabolomics approaches. Furthermore, we aimed to detect biochemical mechanisms relevant to the pathophysiology of SSc. Experiments were performed using high-performance liquid chromatography coupled to mass spectrometry technology. The investigation of plasma samples from SSc patients (
Identifiants
pubmed: 35327409
pii: biomedicines10030607
doi: 10.3390/biomedicines10030607
pmc: PMC8945346
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Postdoc-toral scholarship for medical doctors in Upper Austria
ID : x
Organisme : Clinician scientist grant of the Austrian Society of Dermatology and Venereology
ID : x
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