Development and Biological Characterization of a Novel Selective TrkA Agonist with Neuroprotective Properties against Amyloid Toxicity.
Alzheimer disease
LTP
TrkA neurotrophin receptor
amyloid-beta
nerve growth factor
neuronal survival
neurotrophin
neurotrophin mimetic
synapse
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
06 Mar 2022
06 Mar 2022
Historique:
received:
12
01
2022
revised:
23
02
2022
accepted:
03
03
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
26
3
2022
Statut:
epublish
Résumé
Neurotrophins are growth factors that exert important neuroprotective effects by preventing neuronal death and synaptic loss. Nerve Growth Factor (NGF) acts through the activation of its high-affinity, pro-survival TrkA and low-affinity, pro-apoptotic p75
Identifiants
pubmed: 35327415
pii: biomedicines10030614
doi: 10.3390/biomedicines10030614
pmc: PMC8945229
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : European Union's Horizon 2020 research and innovation programme "Euroneurotrophin" under the Marie Skłodowska-Curie grant agreement No 765704.
ID : 765704
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