Glioblastoma in the Elderly: Review of Molecular and Therapeutic Aspects.
comprehensive geriatric assessment
elderly patients
glioblastoma
molecular factors
prognostic factors
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
10 Mar 2022
10 Mar 2022
Historique:
received:
13
02
2022
revised:
07
03
2022
accepted:
08
03
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
26
3
2022
Statut:
epublish
Résumé
Glioblastoma (GBM) is the most aggressive primary brain tumour. As GBM incidence is associated with age, elderly people represent a consistent subgroup of patients. Elderly people with GBM show dismal prognosis (about 6 months) and limited response to treatments. Age is a negative prognostic factor, which correlates with clinical frailty, poorer tolerability to surgery or adjuvant radio-chemotherapy, and higher occurrence of comorbidities and/or secondary complications. The aim of this paper is to review the clinical and molecular characteristics, current therapeutic options, and prognostic factors of elderly patients with GBM.
Identifiants
pubmed: 35327445
pii: biomedicines10030644
doi: 10.3390/biomedicines10030644
pmc: PMC8945166
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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