ER-phagy in the Occurrence and Development of Cancer.
ER-phagy
apoptosis
cancer
unfolded protein response
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
18 Mar 2022
18 Mar 2022
Historique:
received:
14
01
2022
revised:
11
03
2022
accepted:
16
03
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
26
3
2022
Statut:
epublish
Résumé
As an organelle, the endoplasmic reticulum (ER) is closely related to protein synthesis and modification. When physiological or pathological stimuli induce disorders of ER function, misfolded proteins trigger ER-phagy, which is beneficial for restoring cell homeostasis or promoting cell apoptosis. As a double-edged sword, ER-phagy actively participates in various stages of development and progression in tumor cells, regulating tumorigenesis and maintaining tumor cell homeostasis. Through the unfolded protein response (UPR), the B cell lymphoma 2 (BCL-2) protein family, the Caspase signaling pathway, and others, ER-phagy plays an initiating role in tumor occurrence, migration, stemness, and proliferation. At the same time, many vital proteins strongly associated with ER-phagy, such as family with sequence similarity 134 member B (FAM134B), translocation protein SEC62 (SEC62), and C/EBP-homologous protein (CHOP), can produce a marked effect in many complex environments, which ultimately lead to entirely different tumor fates. Our article comprehensively focused on introducing the relationship and interaction between ER-phagy and cancers, as well as their molecular mechanism and regulatory pathways. Via these analyses, we tried to clarify the possibility of ER-phagy as a potential target for cancer therapy and provide ideas for further research.
Identifiants
pubmed: 35327508
pii: biomedicines10030707
doi: 10.3390/biomedicines10030707
pmc: PMC8945671
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : National Key Research and Development Program of China
ID : 2016YFA0201504
Organisme : National Natural Science Foundation of China
ID : 81473249 and 81102464
Organisme : National Mega-project for Innovative Drugs
ID : 2014ZX09201042
Organisme : the CAMS Innovation Fund for Medical Sciences (CIFMS)
ID : 2016-I2M-2-002
Organisme : Drug Innovation Major Project of China
ID : 2018ZX09711001-007-002
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