Calculated Tumor-Associated Neutrophils Are Associated with the Tumor-Stroma Ratio and Predict a Poor Prognosis in Advanced Gastric Cancer.
gastric cancer
prognostic factor
tumor-associated neutrophils
tumor—stroma ratio
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
18 Mar 2022
18 Mar 2022
Historique:
received:
28
02
2022
revised:
17
03
2022
accepted:
17
03
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
26
3
2022
Statut:
epublish
Résumé
The tumor-associated neutrophils (TANs) value and tumor-stroma ratio (TSR) are promising prognostic parameters in the tumor microenvironment. We aimed to evaluate the prognostic role and relationship of TANs and TSR in gastric cancer. Our study comprised 157 patients who underwent gastrectomy for advanced gastric cancer. TANs were assessed by immunohistochemical staining (CD15 and CD66b) and were analyzed with an image analyzer. TANs have been known to have different functional subpopulations of N1 (anti-tumor) and N2 (pro-tumor). We developed "calculated TANs with pro-tumor function (cN2; CD15 minus CD66b)". The TSR was evaluated using hematoxylin and eosin staining. High-grade CD15-positive, cN2 in the tumor center, and TSR were significantly related to poor disease-free survival (DFS). TSR and cN2 were independent prognostic factors for DFS (hazard ratio (HR) = 2.614;
Identifiants
pubmed: 35327509
pii: biomedicines10030708
doi: 10.3390/biomedicines10030708
pmc: PMC8945075
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Research Foundation of Korea
ID : 2021R1I1A1A01060037
Organisme : The Catholic University of Korea, Ui- 298 jeongbu St. Mary's Hospital Clinical Research Laboratory Foundation made in the program year of 2022
ID : UJBCRL202205
Références
Front Oncol. 2021 May 26;11:685570
pubmed: 34123856
Front Immunol. 2018 Nov 09;9:2456
pubmed: 30473691
PLoS One. 2014 Jun 06;9(6):e98259
pubmed: 24906014
Nat Rev Cancer. 2020 Sep;20(9):485-503
pubmed: 32694624
Clin Transl Med. 2021 Jun;11(6):e484
pubmed: 34185422
Int J Cancer. 2014 Sep 1;135(5):1178-86
pubmed: 24501019
Nat Rev Cancer. 2020 Mar;20(3):174-186
pubmed: 31980749
Mol Cancer. 2021 Oct 11;20(1):131
pubmed: 34635121
Oncotarget. 2016 Oct 18;7(42):68954-68965
pubmed: 27661111
Int J Mol Sci. 2018 May 29;19(6):
pubmed: 29844297
Cell Res. 2020 Jun;30(6):507-519
pubmed: 32467593
Front Oncol. 2021 Aug 17;11:696931
pubmed: 34485133
J Leukoc Biol. 1992 Jul;52(1):11-6
pubmed: 1640165
Front Immunol. 2021 Apr 15;12:602963
pubmed: 33936029
Br Med Bull. 2018 Dec 1;128(1):5-14
pubmed: 30137312
Stroke. 2013 Dec;44(12):3498-508
pubmed: 24135932
Br J Cancer. 2018 Aug;119(4):435-439
pubmed: 30057407
Cancer Med. 2018 May;7(5):1731-1741
pubmed: 29573574
Cancer Discov. 2021 Apr;11(4):933-959
pubmed: 33811125
Front Oncol. 2019 Nov 15;9:1146
pubmed: 31799175
Cancers (Basel). 2021 Jul 07;13(14):
pubmed: 34298621
J Biol Chem. 2001 May 11;276(19):16100-6
pubmed: 11278338
PLoS One. 2012;7(3):e33655
pubmed: 22442706
Semin Immunol. 2020 Apr;48:101417
pubmed: 33077325
Anticancer Res. 2014 Dec;34(12):7129-36
pubmed: 25503140
Mod Pathol. 2002 Aug;15(8):831-7
pubmed: 12181268
Front Immunol. 2020 Apr 28;11:532
pubmed: 32411122
Medicine (Baltimore). 2015 Sep;94(39):e1631
pubmed: 26426650
Virchows Arch. 2016 May;468(5):539-48
pubmed: 26915031
J Cancer Res Clin Oncol. 2020 Jan;146(1):53-66
pubmed: 31741042
Front Immunol. 2020 Dec 02;11:553967
pubmed: 33343560
Gastric Cancer. 2017 Jul;20(4):591-601
pubmed: 27858181
J Exp Clin Cancer Res. 2019 Jan 7;38(1):6
pubmed: 30616627
Carcinogenesis. 2012 May;33(5):949-55
pubmed: 22425643
BMJ. 2015 Aug 11;351:h3868
pubmed: 26264962
Ann Surg. 2018 Feb;267(2):311-318
pubmed: 27763900
Nat Rev Clin Oncol. 2019 Oct;16(10):601-620
pubmed: 31160735
Cell Death Dis. 2018 Mar 19;9(4):422
pubmed: 29556041
Cancer Med. 2020 Apr;9(8):2761-2773
pubmed: 32096331
Cancer Lett. 2017 Feb 28;387:61-68
pubmed: 26845449
Nat Rev Cancer. 2016 Jul;16(7):431-46
pubmed: 27282249
Front Oncol. 2020 Sep 21;10:570113
pubmed: 33072602