Some Insights into the Regulation of Cardiac Physiology and Pathology by the Hippo Pathway.
Hippo signaling
TAZ
YAP1
cardiac disease
cardiac physiology
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
21 Mar 2022
21 Mar 2022
Historique:
received:
28
01
2022
revised:
17
03
2022
accepted:
19
03
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
26
3
2022
Statut:
epublish
Résumé
The heart is one of the most fascinating organs in living beings. It beats up to 100,000 times a day throughout the lifespan, without resting. The heart undergoes profound anatomical, biochemical, and functional changes during life, from hypoxemic fetal stages to a completely differentiated four-chambered cardiac muscle. In the middle, many biological events occur after and intersect with each other to regulate development, organ size, and, in some cases, regeneration. Several studies have defined the essential roles of the Hippo pathway in heart physiology through the regulation of apoptosis, autophagy, cell proliferation, and differentiation. This molecular route is composed of multiple components, some of which were recently discovered, and is highly interconnected with multiple known prosurvival pathways. The Hippo cascade is evolutionarily conserved among species, and in addition to its regulatory roles, it is involved in disease by drastically changing the heart phenotype and its function when its components are mutated, absent, or constitutively activated. In this review, we report some insights into the regulation of cardiac physiology and pathology by the Hippo pathway.
Identifiants
pubmed: 35327528
pii: biomedicines10030726
doi: 10.3390/biomedicines10030726
pmc: PMC8945338
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Ministero della Salute
ID : GR-2013-02356747
Organisme : Ministero della Salute
ID : GR-2019-12369862
Organisme : Italian Association for Cancer Research
ID : IG-23670
Organisme : Italian Association for Cancer Research
ID : IG-19803
Organisme : European Research Council
ID : 853057-InflaPML
Pays : International
Références
Development. 2013 Dec;140(23):4683-90
pubmed: 24255096
Tumour Biol. 2016 Jul;37(7):8471-86
pubmed: 27059734
Nat Cell Biol. 2006 Jan;8(1):27-36
pubmed: 16341207
J Cell Mol Med. 2018 Oct;22(10):5132-5144
pubmed: 30063115
Dev Cell. 2009 Mar;16(3):411-20
pubmed: 19289086
Science. 2002 Dec 13;298(5601):2188-90
pubmed: 12481136
Sci Transl Med. 2021 Jun 30;13(600):
pubmed: 34193613
J Clin Invest. 2003 May;111(10):1463-74
pubmed: 12750396
Biochem J. 2011 Jun 1;436(2):213-24
pubmed: 21568941
Circ Res. 2014 Jan 31;114(3):454-68
pubmed: 24276085
Front Cell Dev Biol. 2021 Apr 01;9:658481
pubmed: 33869224
Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13839-44
pubmed: 23918388
Cardiovasc Res. 2021 Jun 16;:
pubmed: 34132780
Sensors (Basel). 2017 Feb 05;17(2):
pubmed: 28165432
JCI Insight. 2017 Sep 7;2(17):
pubmed: 28878117
Genes Dev. 1995 Mar 1;9(5):534-46
pubmed: 7698644
Science. 2010 Dec 3;330(6009):1344-8
pubmed: 21127245
Dev Cell. 2010 Oct 19;19(4):491-505
pubmed: 20951342
J Cell Sci. 2005 May 1;118(Pt 9):1779-87
pubmed: 15860727
J Biol Chem. 2019 Mar 8;294(10):3603-3617
pubmed: 30635403
J Mol Cell Cardiol. 2021 Feb;151:15-30
pubmed: 33159916
Am J Physiol Heart Circ Physiol. 2020 Jul 1;319(1):H89-H99
pubmed: 32502376
Sci Signal. 2011 Oct 25;4(196):ra70
pubmed: 22028467
Cell. 2013 Sep 12;154(6):1342-55
pubmed: 24012335
Curr Biol. 2013 Mar 4;23(5):430-5
pubmed: 23434281
Development. 1995 Apr;121(4):1053-63
pubmed: 7743921
J Physiol Sci. 2019 Jan;69(1):113-127
pubmed: 29961191
Cell. 2003 Apr 4;113(1):25-36
pubmed: 12679032
Acta Cardiol Sin. 2018 Mar;34(2):115-123
pubmed: 29643696
Cell. 2006 Aug 25;126(4):767-74
pubmed: 16923395
Nat Commun. 2018 Nov 1;9(1):4564
pubmed: 30385786
J Biol Chem. 1999 Dec 31;274(53):37538-43
pubmed: 10608806
J Biol Chem. 2001 May 4;276(18):15164-73
pubmed: 11278685
Trends Cell Biol. 2012 Jul;22(7):339-46
pubmed: 22658639
Cell. 2008 Jan 11;132(1):27-42
pubmed: 18191218
Circ Res. 2014 Jul 18;115(3):354-63
pubmed: 24833660
Cell. 2011 Nov 11;147(4):742-58
pubmed: 22078876
Nat Cell Biol. 2008 Jul;10(7):837-48
pubmed: 18568018
J Clin Invest. 2010 Oct;120(10):3555-67
pubmed: 20890045
Front Pharmacol. 2021 Jan 11;11:593225
pubmed: 33584269
J Exp Med. 2020 Jun 1;217(6):
pubmed: 32271880
Cancer Discov. 2018 Aug;8(8):1026-1043
pubmed: 29907586
Nat Rev Cardiol. 2018 Nov;15(11):672-684
pubmed: 30111784
Nat Rev Drug Discov. 2014 Jan;13(1):63-79
pubmed: 24336504
Mol Cell. 2017 Nov 2;68(3):591-604.e5
pubmed: 29100056
Development. 2011 Jan;138(1):9-22
pubmed: 21138973
Dev Biol. 2011 Jun 1;354(1):67-76
pubmed: 21457708
Eur Heart J. 2008 Jan;29(2):270-6
pubmed: 17916581
Development. 2011 Sep;138(18):3907-14
pubmed: 21831922
Science. 2011 Apr 22;332(6028):458-61
pubmed: 21512031
Genes Dev. 2019 Nov 1;33(21-22):1491-1505
pubmed: 31558567
Mol Cell. 2014 May 22;54(4):639-50
pubmed: 24813943
J Cell Physiol. 2020 Jan;235(1):317-327
pubmed: 31215035
Science. 2011 Feb 25;331(6020):1078-80
pubmed: 21350179
Genes (Basel). 2016 May 18;7(5):
pubmed: 27213455
Nature. 2011 Jun 08;474(7350):179-83
pubmed: 21654799
Adv Drug Deliv Rev. 2019 Jun;146:77-82
pubmed: 31158407
Curr Biol. 2007 Apr 17;17(8):700-5
pubmed: 17379520
Cell Rep. 2016 May 17;15(7):1384-1393
pubmed: 27160901
Int J Cardiol. 2017 Oct 1;244:59-66
pubmed: 28634037
Cell. 2011 Nov 11;147(4):728-41
pubmed: 22078875
Nature. 2017 Jul 13;547(7662):179-184
pubmed: 28581497
Nature. 2008 Jul 24;454(7203):428-35
pubmed: 18650913
Cell Death Differ. 2008 Jul;15(7):1132-8
pubmed: 18437164
Nat Immunol. 2017 Jul;18(7):800-812
pubmed: 28504697
J Clin Invest. 2019 Feb 1;129(2):802-819
pubmed: 30511961
Cell Rep. 2019 Apr 23;27(4):1176-1189.e5
pubmed: 31018132
J Biol Chem. 2018 Nov 23;293(47):18071-18085
pubmed: 30315101
Nature. 2016 May 25;534(7605):119-23
pubmed: 27251288
Circ Res. 2021 Jan 8;128(1):24-38
pubmed: 33106094
J Biol Chem. 2014 Aug 29;289(35):24275-88
pubmed: 25035424
JCI Insight. 2016 Apr 21;1(5):
pubmed: 27218122
Nat Rev Cardiol. 2019 Sep;16(9):519-537
pubmed: 31028357
Am J Physiol Heart Circ Physiol. 2019 Jan 1;316(1):H45-H60
pubmed: 30387702
Dev Cell. 2016 Feb 22;36(4):362-74
pubmed: 26906733
Front Immunol. 2020 Mar 24;11:534
pubmed: 32265942
Cardiovasc Res. 2021 Aug 10;:
pubmed: 34375401
Physiol Rev. 2008 Apr;88(2):581-609
pubmed: 18391174
Front Med (Lausanne). 2015 Sep 03;2:59
pubmed: 26389119
Exp Biol Med (Maywood). 2019 Jul;244(10):802-812
pubmed: 31142144
J Biol Chem. 2010 Nov 26;285(48):37159-69
pubmed: 20858893
Oncogene. 2002 Jul 25;21(32):4879-84
pubmed: 12118366
Curr Treat Options Cardiovasc Med. 2014 Mar;16(3):288
pubmed: 24496965
Cell Biosci. 2013 Aug 28;3(1):32
pubmed: 23985307
Nat Cell Biol. 2015 Apr;17(4):500-10
pubmed: 25751140
J Mol Cell Cardiol. 2019 Mar;128:90-95
pubmed: 30684499
Genes Dev. 2010 Nov 1;24(21):2430-9
pubmed: 21041411
J Biol Chem. 2003 Aug 29;278(35):33334-41
pubmed: 12807903
J Cardiovasc Pharmacol. 2019 Jan;73(1):27-39
pubmed: 30418242
Semin Cell Dev Biol. 2020 Apr;100:11-19
pubmed: 31606277
Physiol Rev. 2014 Oct;94(4):1287-312
pubmed: 25287865
Front Cell Dev Biol. 2021 Jan 12;8:624216
pubmed: 33511136
Dev Cell. 2008 Mar;14(3):388-98
pubmed: 18258486
Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2394-9
pubmed: 22308401
Basic Res Cardiol. 2014;109(5):435
pubmed: 25168380
Cell. 2015 Nov 5;163(4):811-28
pubmed: 26544935
Nat Med. 2013 Nov;19(11):1478-88
pubmed: 24141421
Cell Cycle. 2008 Feb 1;7(3):318-24
pubmed: 18235243
J Clin Invest. 2017 Mar 1;127(3):899-911
pubmed: 28165342
Mol Cell. 2005 May 13;18(4):447-59
pubmed: 15893728
PLoS Negl Trop Dis. 2022 Jan 5;16(1):e0010074
pubmed: 34986160
Circ Res. 2008 Nov 21;103(11):1309-18
pubmed: 18927464
Dev Cell. 2010 Feb 16;18(2):309-16
pubmed: 20159600
Acta Biochim Pol. 2018;65(3):341-349
pubmed: 30040870
J Biol Chem. 2013 Feb 8;288(6):3977-88
pubmed: 23275380
Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):187-92
pubmed: 23248315
Mol Cell. 2007 Sep 21;27(6):962-75
pubmed: 17889669
Dev Cell. 2019 Mar 25;48(6):765-779.e7
pubmed: 30773489
Genes Dev. 2011 Jan 1;25(1):51-63
pubmed: 21205866
Genes Dev. 2012 Jan 1;26(1):54-68
pubmed: 22215811
Nat Cell Biol. 2011 Aug 01;13(8):877-83
pubmed: 21808241
J Clin Invest. 2019 Apr 15;129(5):2107-2122
pubmed: 30985294
EMBO J. 1999 May 4;18(9):2551-62
pubmed: 10228168
N Engl J Med. 2013 Feb 14;368(7):651-62
pubmed: 23406030
Trends Endocrinol Metab. 2018 Jul;29(7):492-509
pubmed: 29739703
Nat Genet. 2000 Jul;25(3):315-9
pubmed: 10888881
EMBO Rep. 2019 Nov 5;20(11):e48150
pubmed: 31544310
Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20321-6
pubmed: 19073936
Int J Mol Sci. 2021 Jun 07;22(11):
pubmed: 34200497
Dev Biol. 2018 Aug 1;440(1):22-30
pubmed: 29727635
Curr Biol. 2008 Mar 25;18(6):435-41
pubmed: 18313299
Cancer Res. 2019 Dec 15;79(24):6139-6152
pubmed: 31578200
Cancers (Basel). 2021 Jun 21;13(12):
pubmed: 34205830
Semin Cell Dev Biol. 2012 Sep;23(7):803-11
pubmed: 22750148
J Clin Med. 2020 Mar 24;9(3):
pubmed: 32214047
Biomolecules. 2020 Jul 10;10(7):
pubmed: 32664346
Mol Cell. 2015 Jan 8;57(1):55-68
pubmed: 25544559
Dev Dyn. 2012 Jan;241(1):3-15
pubmed: 22174083
Dev Cell. 2013 Jul 29;26(2):188-94
pubmed: 23850191
Cell. 2003 Aug 22;114(4):457-67
pubmed: 12941274
Cell Death Dis. 2019 Apr 8;10(4):317
pubmed: 30962427
Proc Natl Acad Sci U S A. 1995 May 23;92(11):5022-6
pubmed: 7761441
Mol Cell. 2008 Feb 15;29(3):350-61
pubmed: 18280240
Proc Natl Acad Sci U S A. 2020 May 5;117(18):9896-9905
pubmed: 32321834
J Biol Chem. 2004 Jul 23;279(30):31318-28
pubmed: 15145946
Cell. 2009 Nov 13;139(4):757-69
pubmed: 19914168
Circ Res. 2019 Jan 18;124(2):292-305
pubmed: 30582455
Nature. 2017 Oct 12;550(7675):260-264
pubmed: 28976966
J Vis Exp. 2010 Apr 21;(38):
pubmed: 20410870
Circulation. 2009 Aug 18;120(7):607-16
pubmed: 19652091
Nature. 2017 Jul 13;547(7662):227-231
pubmed: 28581498
Int J Mol Sci. 2020 Jul 12;21(14):
pubmed: 32664627
Biochem Soc Trans. 2004 Jun;32(Pt3):485-8
pubmed: 15157167
Cancer Lett. 2018 Jul 10;426:73-79
pubmed: 29654891
Curr Biol. 2006 Oct 10;16(19):1895-904
pubmed: 16949821
Cell Mol Biol Lett. 2018 May 08;23:21
pubmed: 29760744
Biochim Biophys Acta. 2013 Dec;1833(12):3448-3459
pubmed: 23770045
J Pineal Res. 2017 Sep;63(2):
pubmed: 28480597
Front Cell Dev Biol. 2021 May 24;9:673599
pubmed: 34109179
Theranostics. 2021 Aug 21;11(18):8993-9008
pubmed: 34522223
Redox Biol. 2018 Apr;14:59-71
pubmed: 28869833
Gen Physiol Biophys. 2021 Sep;40(5):419-426
pubmed: 34602455
Cell. 2016 Jan 28;164(3):406-19
pubmed: 26824654
Circ Res. 2007 May 11;100(9):1344-52
pubmed: 17395874
PLoS Biol. 2020 Dec 2;18(12):e3000941
pubmed: 33264286
JACC Basic Transl Sci. 2018 Nov 12;3(5):639-653
pubmed: 30456335
Sci Signal. 2015 May 05;8(375):ra41
pubmed: 25943351