Posterior Fossa Tumours in the First Year of Life: A Two-Centre Retrospective Study.
Atypical Teratoid/Rhabdoid Tumour
astrocytoma
ependymoma
infants
infratentorial tumours
medulloblastoma
posterior fossa tumours
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
04 Mar 2022
04 Mar 2022
Historique:
received:
07
02
2022
revised:
25
02
2022
accepted:
01
03
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
26
3
2022
Statut:
epublish
Résumé
Posterior fossa tumours (PFTs) in infants are very rare, and information on these tumours is scarce in the literature. This retrospective study reports their pathological characteristics and describes surgical aspects and treatment outcomes. A two-centre cohort of infants with PFTs treated from 2007 to 2018 was retrospectively reviewed. Patient characteristics, clinical, and treatment data were reviewed. Survival curves for progression-free survival (PFS) and overall survival (OS) were generated. Thirty-three infants were retrieved. There were 11 low grade and 22 high-grade tumours. The most common presenting symptom was intracranial hypertension. Fifteen children out of thirty-three progressed. Five-year PFS was significantly lower in children with high-grade tumours (38.3%) than those with low-grade tumours (69.3%),
Identifiants
pubmed: 35328188
pii: diagnostics12030635
doi: 10.3390/diagnostics12030635
pmc: PMC8947426
pii:
doi:
Types de publication
Journal Article
Langues
eng
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