Reactive Oxygen Species and Folate Receptor-Targeted Nanophotosensitizers Composed of Folic Acid-Conjugated and Poly(ethylene glycol)-Chlorin e6 Tetramer Having Diselenide Linkages for Targeted Photodynamic Treatment of Cancer Cells.
Cell Line, Tumor
Chlorophyllides
Folic Acid
/ therapeutic use
Humans
Hydrogen Peroxide
/ therapeutic use
Nanoparticles
Neoplasms
/ drug therapy
Photochemotherapy
/ methods
Photosensitizing Agents
/ therapeutic use
Polyethylene Glycols
/ therapeutic use
Porphyrins
Reactive Oxygen Species
/ metabolism
drug targeting
nanophotosensitizers
photodynamic therapy
reactive oxygen species
retinoblastoma
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 Mar 2022
14 Mar 2022
Historique:
received:
19
01
2022
revised:
10
03
2022
accepted:
10
03
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
9
4
2022
Statut:
epublish
Résumé
Folic acid-conjugated nanophotosensitizers composed of folic acid (FA), poly(ethylene glycol) (PEG) and chlorin e6 (Ce6) tetramer were synthesized using diselenide linkages for reactive oxygen species (ROS)- and folate receptor-specific delivery of photosensitizers. Ce6 was conjugated with 3-[3-(2-carboxyethoxy)-2,2-bis(2-carboxyethoxymethyl)propoxy]propanoic acid (tetra acid, or TA) to make Ce6 tetramer via selenocystamine linkages (TA-sese-Ce6 conjugates). In the carboxylic acid end group of the TA-sese-Ce6 conjugates, FA-PEG was attached again using selenocystamine linkages to make FA-PEG/TA-sese-Ce6 conjugates (abbreviated as FAPEGtaCe6 conjugates). Nanophotosensitizers were fabricated by a dialysis procedure. In the morphological observations, they showed spherical shapes with small diameters of less than 200 nm. Stability of the aqueous FAPEGtaCe6 nanophotosensitizer solution was maintained (i.e., their particle sizes were not significantly changed until 7 days later). When H
Identifiants
pubmed: 35328538
pii: ijms23063117
doi: 10.3390/ijms23063117
pmc: PMC8954463
pii:
doi:
Substances chimiques
Chlorophyllides
0
Photosensitizing Agents
0
Porphyrins
0
Reactive Oxygen Species
0
Polyethylene Glycols
3WJQ0SDW1A
phytochlorin
5S2CCF3T1Z
Folic Acid
935E97BOY8
Hydrogen Peroxide
BBX060AN9V
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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