Pial Vessel-Associated Microglia/Macrophages Increase in Female Dahl-SS/Jr Rats Independent of Pregnancy History.
Iba1
border-associated cells
hypertension
meninges
myeloid cells
perivascular macrophages
vascular-associated microglia
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
21 Mar 2022
21 Mar 2022
Historique:
received:
31
01
2022
revised:
18
03
2022
accepted:
18
03
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
9
4
2022
Statut:
epublish
Résumé
As the resident immune cells of the central nervous system, microglia have a wide range of functions such as surveillance, phagocytosis, and signaling through production of chemokines and cytokines. Recent studies have identified and characterized macrophages residing at the meninges, a series of layers surrounding the brain and spinal cord. While perivascular microglia within the brain parenchyma increase following chronic hypertension, there are no reports of changes at the meninges, and specifically, associated with the pial vasculature. Thus, we used female Sprague Dawley and Dahl salt-sensitive (SS/Jr) rat brains, stained for ionized calcium-binding adapter molecule (Iba1), and characterized microglia/macrophages associated with pial vessels in the posterior brain. Results indicate that Iba1
Identifiants
pubmed: 35328808
pii: ijms23063384
doi: 10.3390/ijms23063384
pmc: PMC8950577
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : R01HL134711
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL094446
Pays : United States
Organisme : NHLBI NIH HHS
ID : R25 HL145817
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL134711
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137673
Pays : United States
Organisme : NIH HHS
ID : R01HL137673
Pays : United States
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