Mechanisms and Applications of Bacterial Sporulation and Germination in the Intestine.
drug delivery system
inflammatory bowel disease
microbiome
probiotics
spore
sporobiota
vaccine vehicle
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
21 Mar 2022
21 Mar 2022
Historique:
received:
18
02
2022
revised:
15
03
2022
accepted:
18
03
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
9
4
2022
Statut:
epublish
Résumé
Recent studies have suggested a major role for endospore forming bacteria within the gut microbiota, not only as pathogens but also as commensal and beneficial members contributing to gut homeostasis. In this review the sporulation processes, spore properties, and germination processes will be explained within the scope of the human gut. Within the gut, spore-forming bacteria are known to interact with the host's immune system, both in vegetative cell and spore form. Together with the resistant nature of the spore, these characteristics offer potential for spores' use as delivery vehicles for therapeutics. In the last part of the review, the therapeutic potential of spores as probiotics, vaccine vehicles, and drug delivery systems will be discussed.
Identifiants
pubmed: 35328823
pii: ijms23063405
doi: 10.3390/ijms23063405
pmc: PMC8953710
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Genome Biol. 2021 Aug 5;22(1):204
pubmed: 34348764
Hum Vaccin Immunother. 2014;10(12):3649-58
pubmed: 25483702
J Bacteriol. 1966 Mar;91(3):1168-77
pubmed: 4956331
Parasitology. 2020 Sep;147(10):1080-1087
pubmed: 32404215
Microb Cell Fact. 2010 Jan 18;9:2
pubmed: 20082702
Emerg Microbes Infect. 2018 Aug 6;7(1):141
pubmed: 30082713
Microbiology (Reading). 2002 Jul;148(Pt 7):2089-2095
pubmed: 12101297
Annu Rev Microbiol. 2001;55:647-71
pubmed: 11544370
Appl Environ Microbiol. 2005 Feb;71(2):774-81
pubmed: 15691930
Food Microbiol. 2014 Dec;44:24-33
pubmed: 25084641
Nutrients. 2020 Nov 24;12(12):
pubmed: 33255321
Infect Immun. 2008 Nov;76(11):5257-65
pubmed: 18779344
PLoS One. 2019 Jun 14;14(6):e0218220
pubmed: 31199835
Front Microbiol. 2020 Jan 31;10:3122
pubmed: 32082270
Genes Dev. 2001 May 1;15(9):1093-103
pubmed: 11331605
Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6792-6800
pubmed: 32152097
J Bacteriol. 2013 Apr;195(7):1492-503
pubmed: 23335421
J Control Release. 2018 Feb 10;271:31-44
pubmed: 29274436
J Appl Microbiol. 2005;98(3):606-17
pubmed: 15715863
Infect Immun. 2003 May;71(5):2810-8
pubmed: 12704155
Infect Immun. 2017 Mar 23;85(4):
pubmed: 28167669
PLoS Genet. 2019 Jul 5;15(7):e1008224
pubmed: 31276487
Infect Immun. 2014 Apr;82(4):1414-23
pubmed: 24421038
Can J Microbiol. 1966 Feb;12(1):199-201
pubmed: 4958826
PLoS Pathog. 2017 Jul 13;13(7):e1006443
pubmed: 28704538
J Bacteriol. 2015 Oct 19;198(1):168-77
pubmed: 26483518
Cell Mol Immunol. 2021 May;18(5):1161-1171
pubmed: 33850311
Int J Mol Sci. 2020 Sep 13;21(18):
pubmed: 32933117
Cell. 2006 May 19;125(4):679-90
pubmed: 16713562
J Immunol. 2004 Jan 15;172(2):1118-24
pubmed: 14707086
FEMS Microbiol Ecol. 2005 Jan 1;51(2):231-6
pubmed: 16329871
Appl Environ Microbiol. 2020 Aug 18;86(17):
pubmed: 32631858
ISME J. 2018 Oct;12(10):2403-2416
pubmed: 29899513
Infect Immun. 2011 Jun;79(6):2295-302
pubmed: 21482682
Nat Rev Microbiol. 2003 Nov;1(2):117-26
pubmed: 15035041
Mol Cell. 1999 Nov;4(5):665-72
pubmed: 10619014
Environ Microbiol. 2018 Jan;20(1):324-336
pubmed: 29159997
Acta Medica (Hradec Kralove). 2010;53(2):73-7
pubmed: 20672742
Vaccine. 2004 Mar 12;22(9-10):1177-87
pubmed: 15003646
Nutrients. 2018 Aug 12;10(8):
pubmed: 30103531
Gene. 1987;51(1):1-11
pubmed: 3110007
Nature. 2016 May 04;533(7604):543-546
pubmed: 27144353
J Appl Microbiol. 2012 Sep;113(3):485-98
pubmed: 22574673
Biophys J. 2013 Nov 5;105(9):2016-23
pubmed: 24209846
Proc Natl Acad Sci U S A. 1969 Oct;64(2):528-35
pubmed: 4982357
J Bacteriol. 1964 Nov;88:1403-15
pubmed: 14234800
Curr Opin Microbiol. 2000 Dec;3(6):561-6
pubmed: 11121774
Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3007-9
pubmed: 12631692
Microbiology (Reading). 2002 Aug;148(Pt 8):2383-2392
pubmed: 12177332
Infect Immun. 1998 Dec;66(12):5698-702
pubmed: 9826344
Cell. 2008 Oct 31;135(3):486-96
pubmed: 18984160
J Med Microbiol. 2017 Jan;66(1):83-89
pubmed: 27930268
Proc Natl Acad Sci U S A. 2004 May 18;101(20):7733-8
pubmed: 15126669
J Gen Microbiol. 1970 Mar;60(3):347-55
pubmed: 4992199
Curr Opin Microbiol. 2004 Dec;7(6):579-86
pubmed: 15556029
Int Rev Immunol. 2009;28(6):487-505
pubmed: 19954360
J Cell Biochem. 1993 Jan;51(1):55-61
pubmed: 8432743
J Food Prot. 2003 May;66(5):833-9
pubmed: 12747693
Cell. 1991 Feb 8;64(3):545-52
pubmed: 1846779
Appl Environ Microbiol. 2000 Jun;66(6):2627-30
pubmed: 10831447
Mol Microbiol. 2019 Mar;111(3):825-843
pubmed: 30582883
Mol Microbiol. 2019 Nov;112(5):1576-1592
pubmed: 31502725
Vaccine. 2010 Jan 22;28(4):1021-30
pubmed: 19914191
Infect Immun. 2007 May;75(5):2351-8
pubmed: 17339355
PLoS One. 2018 Jan 25;13(1):e0191627
pubmed: 29370221
Biotechnol Adv. 2021 Mar-Apr;47:107693
pubmed: 33387640
J Appl Microbiol. 2011 Sep;111(3):663-70
pubmed: 21714839
J Bacteriol. 2010 Jul;192(14):3608-19
pubmed: 20472791
J Bacteriol. 2008 Apr;190(7):2505-12
pubmed: 18245298
Microb Cell Fact. 2012 Aug 03;11:100
pubmed: 22863452
Microbiol Spectr. 2015 Dec;3(6):
pubmed: 27337279
Nutr Rev. 2017 Apr 1;75(4):286-305
pubmed: 28402523
J Bacteriol. 1996 Apr;178(8):2204-10
pubmed: 8636019
J Innate Immun. 2012;4(2):149-58
pubmed: 22237401
ISME J. 2016 Nov;10(11):2633-2642
pubmed: 27105070
J Bacteriol. 2006 Jan;188(1):28-36
pubmed: 16352818
Int J Biol Macromol. 2019 Apr 15;127:406-414
pubmed: 30654039
Annu Rev Microbiol. 2015;69:445-61
pubmed: 26488281
Appl Environ Microbiol. 2012 Apr;78(8):2689-97
pubmed: 22327596
J Biol Chem. 2005 Dec 30;280(52):43073-8
pubmed: 16249180
Int J Syst Bacteriol. 1994 Oct;44(4):812-26
pubmed: 7981107
Microbiol Mol Biol Rev. 2013 Jun;77(2):208-33
pubmed: 23699255
Clin Cancer Res. 2021 Jan 1;27(1):96-106
pubmed: 33046513
Parasitol Res. 2014 Aug;113(8):3095-103
pubmed: 24906994
Appl Environ Microbiol. 1978 Apr;35(4):762-5
pubmed: 348108
FEMS Microbiol Rev. 2008 Jul;32(4):579-606
pubmed: 18422617
Infect Immun. 2013 Oct;81(10):3757-69
pubmed: 23897605
Microbes Infect. 2006 May;8(6):1483-91
pubmed: 16697234
Infect Genet Evol. 2011 Aug;11(6):1218-24
pubmed: 21640849
Gut Microbes. 2012 Jan-Feb;3(1):4-14
pubmed: 22356853
J Appl Microbiol. 2009 Jun;106(6):2064-78
pubmed: 19291241
J Bacteriol. 1992 Feb;174(3):807-14
pubmed: 1732215
J Bacteriol. 2011 Aug;193(16):4192-8
pubmed: 21685276
Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9038-43
pubmed: 11470912
Infect Immun. 2009 Jan;77(1):274-85
pubmed: 18955476
Anaerobe. 2016 Oct;41:68-78
pubmed: 27108093
Science. 2003 Jan 24;299(5606):532-6
pubmed: 12493822
Cell Signal. 2020 Oct;74:109729
pubmed: 32721540
J Bacteriol. 2012 Apr;194(8):1875-84
pubmed: 22328679
Appl Environ Microbiol. 2018 Jan 17;84(3):
pubmed: 29150519
FEMS Microbiol Rev. 2012 Jan;36(1):131-48
pubmed: 22091839
J Vis Exp. 2016 Jan 21;(107):e53411
pubmed: 26863128
BMC Vet Res. 2020 Jul 28;16(1):259
pubmed: 32723323
Mol Microbiol. 2011 May;80(3):641-54
pubmed: 21401736
Benef Microbes. 2018 Apr 25;9(3):357-365
pubmed: 29482338
Genes Dev. 2005 Sep 15;19(18):2236-44
pubmed: 16166384
Gut Microbes. 2016 May 3;7(3):189-200
pubmed: 26963409
Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19334-9
pubmed: 19892742
J Clin Invest. 1973 Jul;52(7):1586-94
pubmed: 4718954
Mol Microbiol. 2011 Aug;81(4):1061-77
pubmed: 21696470
Biochemistry. 2002 Sep 24;41(38):11325-30
pubmed: 12234173
Front Microbiol. 2020 Oct 26;11:596092
pubmed: 33193276
Mil Med Res. 2017 Apr 27;4:14
pubmed: 28465831
J Bacteriol. 2010 Jan;192(2):418-25
pubmed: 19915025
Microbiol Spectr. 2019 Nov;7(6):
pubmed: 31858953
Annu Rev Microbiol. 2007;61:555-88
pubmed: 18035610
Curr Opin Microbiol. 2003 Dec;6(6):550-6
pubmed: 14662349
Appl Environ Microbiol. 2018 Oct 1;84(20):
pubmed: 30097448
PLoS Pathog. 2009 Oct;5(10):e1000626
pubmed: 19834554
AMB Express. 2020 Dec 14;10(1):215
pubmed: 33315153
FEMS Microbiol Lett. 2001 Feb 5;195(1):1-8
pubmed: 11166987
Nutrients. 2019 Aug 21;11(9):
pubmed: 31438618
Infect Immun. 2015 Mar;83(3):934-41
pubmed: 25534943
Appl Environ Microbiol. 2020 Apr 1;86(8):
pubmed: 32060024
Photochem Photobiol Sci. 2002 Apr;1(4):225-36
pubmed: 12661961
Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8063-8
pubmed: 10869437
Cell. 2001 Jan 26;104(2):269-79
pubmed: 11207367
Appl Environ Microbiol. 2002 Jun;68(6):3172-5
pubmed: 12039788
Adv Immunol. 2010;107:153-85
pubmed: 21034974
J Appl Microbiol. 2001 Aug;91(2):364-72
pubmed: 11473602
Nat Rev Microbiol. 2021 Jan;19(1):55-71
pubmed: 32887946
Appl Environ Microbiol. 2010 Sep;76(17):5926-33
pubmed: 20601499
FASEB J. 2015 Apr;29(4):1395-403
pubmed: 25550456
J Appl Microbiol. 2006 Sep;101(3):514-25
pubmed: 16907802
mBio. 2015 Feb 24;6(2):e02569
pubmed: 25714717
J Bacteriol. 1953 Feb;65(2):160-6
pubmed: 13034709
Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4333-4
pubmed: 16537368
J Appl Microbiol. 2021 Feb;130(2):314-324
pubmed: 32473615
J Appl Microbiol. 2008 Oct;105(4):1081-90
pubmed: 18498350
Parasit Vectors. 2018 Mar 7;11(1):156
pubmed: 29514667
Sci Rep. 2020 Sep 14;10(1):15041
pubmed: 32929101
Infect Immun. 2006 Jun;74(6):3651-6
pubmed: 16714597
PLoS Pathog. 2013 May;9(5):e1003356
pubmed: 23675301
Nat Microbiol. 2019 Dec;4(12):2064-2073
pubmed: 31477894
Trends Microbiol. 2020 Sep;28(9):744-752
pubmed: 32781028
Curr Microbiol. 2013 Jul;67(1):1-8
pubmed: 23380802
Nature. 2018 Oct;562(7728):532-537
pubmed: 30305736
J Microbiol Biotechnol. 2019 Sep 28;29(9):1335-1340
pubmed: 31434172
Lett Appl Microbiol. 2003;36(1):41-5
pubmed: 12485340
Microorganisms. 2021 Aug 02;9(8):
pubmed: 34442730
Sci Rep. 2020 Feb 4;10(1):1832
pubmed: 32020012
Parasitol Res. 2009 Nov;105(6):1643-51
pubmed: 19756753
Nature. 2000 Oct 19;407(6806):897-900
pubmed: 11057666
Genes Dev. 2009 Aug 15;23(16):1959-70
pubmed: 19684115
Nutrients. 2019 Aug 05;11(8):
pubmed: 31387262
J Infect Dis. 2016 Jul 15;214(2):173-81
pubmed: 26908752
Parasitol Res. 2008 Jan;102(2):293-7
pubmed: 17924143
Microbiol Mol Biol Rev. 2015 Dec;79(4):437-57
pubmed: 26512126
Clin Microbiol Rev. 2015 Jul;28(3):721-41
pubmed: 26085550
J Bacteriol. 2006 Nov;188(21):7470-6
pubmed: 16936012
Trends Microbiol. 2007 Apr;15(4):172-80
pubmed: 17336071
Microb Cell Fact. 2019 Jun 7;18(1):103
pubmed: 31170996
Nat Rev Microbiol. 2017 Sep;15(9):531-543
pubmed: 28603278
J Appl Microbiol. 2003;95(3):637-48
pubmed: 12911713
Genes Dev. 2002 Dec 15;16(24):3253-64
pubmed: 12502745
Gene Ther. 1997 Aug;4(8):791-6
pubmed: 9338007
Annu Rev Microbiol. 1993;47:441-65
pubmed: 8257105
Molecules. 2021 Feb 23;26(4):
pubmed: 33672137
Gastroenterology. 2021 Jan;160(1):115-127.e30
pubmed: 32763240
Vaccine. 2008 Mar 28;26(15):1817-25
pubmed: 18329763
Nutrients. 2019 Apr 11;11(4):
pubmed: 30979002
FEMS Immunol Med Microbiol. 2008 Jul;53(2):195-203
pubmed: 18430003
Mol Biol Evol. 2019 Dec 1;36(12):2714-2736
pubmed: 31350897
Environ Microbiol. 2013 Oct;15(10):2631-41
pubmed: 23834245
J Biol Chem. 2011 Feb 18;286(7):5278-88
pubmed: 21135105
J Bacteriol. 2011 Jun;193(11):2776-83
pubmed: 21478359
Food Microbiol. 2011 Apr;28(2):214-20
pubmed: 21315976
Mol Microbiol. 1997 Jun;24(5):905-15
pubmed: 9219999
J Immunol. 2010 Jun 15;184(12):6782-9
pubmed: 20483765
PLoS One. 2008 Jul 30;3(7):e2793
pubmed: 18665214
J Infect Dis. 2017 Dec 12;216(11):1452-1459
pubmed: 28968845
Gut Pathog. 2017 Jun 30;9:38
pubmed: 28680484
Microbiome. 2020 Jun 30;8(1):103
pubmed: 32605663
Annu Rev Genet. 1995;29:477-508
pubmed: 8825484
BMC Microbiol. 2014 Apr 22;14:101
pubmed: 24755193
J Bacteriol. 1958 Dec;76(6):578-88
pubmed: 13610796
Front Immunol. 2019 Mar 11;10:277
pubmed: 30915065
FEMS Microbiol Lett. 2014 Dec;361(2):95-103
pubmed: 25283838
Microb Cell Fact. 2014 Feb 24;13(1):30
pubmed: 24568122
PLoS Pathog. 2014 Sep 11;10(9):e1004382
pubmed: 25210747
J Bacteriol. 2001 Sep;183(18):5426-30
pubmed: 11514528
Environ Microbiol Rep. 2014 Jun;6(3):212-25
pubmed: 24983526
J Vis Exp. 2019 Mar 19;(145):
pubmed: 30958471
Appl Opt. 2017 Apr 20;56(12):3263-3269
pubmed: 28430241
J Bacteriol. 1998 Sep;180(17):4603-12
pubmed: 9721302
Vaccine. 2014 Mar 10;32(12):1338-45
pubmed: 24486347
J Microbiol Biotechnol. 2019 Feb 28;29(2):179-190
pubmed: 30602268
FEMS Microbiol Lett. 2014 Sep;358(2):170-9
pubmed: 24990572
BMC Biol. 2009 Oct 05;7:66
pubmed: 19804621
Gut Liver. 2014 Jan;8(1):1-6
pubmed: 24516694
Anaerobe. 2014 Dec;30:75-81
pubmed: 25219857
Mol Microbiol. 2002 Jul;45(1):169-78
pubmed: 12100557
Parasitol Res. 2017 Jul;116(7):1811-1822
pubmed: 28502017
Sci Rep. 2018 Jul 30;8(1):11388
pubmed: 30061638
World J Gastroenterol. 2011 Mar 28;17(12):1519-28
pubmed: 21472114
Res Microbiol. 2006 Nov;157(9):891-7
pubmed: 17005378
J Appl Microbiol. 2009 Jul;107(1):318-28
pubmed: 19302310
Gut Microbes. 2021 Jan-Dec;13(1):1-17
pubmed: 33406976
Environ Microbiol. 2020 Sep;22(9):3909-3921
pubmed: 32686173
Appl Environ Microbiol. 2015 Apr;81(8):2927-38
pubmed: 25681191
J Bacteriol. 2003 Nov;185(21):6255-61
pubmed: 14563859
Infect Genet Evol. 2017 Apr;49:1-11
pubmed: 28012982
J Bacteriol. 2016 Jul 13;198(15):2113-30
pubmed: 27246573
Biochimie. 1992 Jul-Aug;74(7-8):723-33
pubmed: 1391052
J Med Microbiol. 2013 Sep;62(Pt 9):1379-1385
pubmed: 23475909
Lancet Gastroenterol Hepatol. 2021 Oct;6(10):784-792
pubmed: 34358486
World J Microbiol Biotechnol. 2021 Aug 5;37(8):144
pubmed: 34351499