Amino Acid-Enriched Formula for the Post-Operative Care of Extraction Sockets Evaluated by 3-D Intraoral Scanning.
Aminogam
amino acids
extraction surgery
hyaluronic acids
wound healing
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
11 03 2022
11 03 2022
Historique:
received:
21
01
2022
revised:
07
03
2022
accepted:
09
03
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
20
4
2022
Statut:
epublish
Résumé
Hyaluronic acid and amino acids play an important role in the wound healing process, stimulating the development of the connective tissue and the activity and proliferation of fibroblasts. The aim of the present controlled clinical study was to evaluate the clinical efficacy of a topical gel formula containing hyaluronic acid and amino acids in terms of wound closure rate, painkiller intake, and patients' reported pain and edema. This study included patients in need of a single tooth extraction. Patients were randomized into two groups with differing post-operative care regimens. Patients in the test group used the amino acid and hyaluronic acid-based gel, while the control group did not use any product. Each parameter was measured in both groups at different time points: immediately after surgery, and after 7, 14, 30, and 60 days. A total of 40 patients (46.52 ± 9.84 years old) completed the observational period, and 40 extraction sockets were examined. After 7 days, the edema was significantly lower in the test group. The reported pain was lower in the test group without a significant difference, except for the first time point at 7 days. With the follow-up questionnaire, patients declared to have taken painkillers mainly during the first 7 days after surgery; however, the test group showed a lower need for painkillers than the control group. The post-operative and domiciliary use of an amino acid and hyaluronic acid-based gel for the management of soft tissue closure after tooth extraction is a valid coadjutant to reduce swelling, pain, and the need for painkillers. Additional studies are required to support the results of the present study.
Sections du résumé
BACKGROUND
Hyaluronic acid and amino acids play an important role in the wound healing process, stimulating the development of the connective tissue and the activity and proliferation of fibroblasts. The aim of the present controlled clinical study was to evaluate the clinical efficacy of a topical gel formula containing hyaluronic acid and amino acids in terms of wound closure rate, painkiller intake, and patients' reported pain and edema.
METHODS
This study included patients in need of a single tooth extraction. Patients were randomized into two groups with differing post-operative care regimens. Patients in the test group used the amino acid and hyaluronic acid-based gel, while the control group did not use any product. Each parameter was measured in both groups at different time points: immediately after surgery, and after 7, 14, 30, and 60 days.
RESULTS
A total of 40 patients (46.52 ± 9.84 years old) completed the observational period, and 40 extraction sockets were examined. After 7 days, the edema was significantly lower in the test group. The reported pain was lower in the test group without a significant difference, except for the first time point at 7 days. With the follow-up questionnaire, patients declared to have taken painkillers mainly during the first 7 days after surgery; however, the test group showed a lower need for painkillers than the control group.
CONCLUSION
The post-operative and domiciliary use of an amino acid and hyaluronic acid-based gel for the management of soft tissue closure after tooth extraction is a valid coadjutant to reduce swelling, pain, and the need for painkillers. Additional studies are required to support the results of the present study.
Identifiants
pubmed: 35328990
pii: ijerph19063302
doi: 10.3390/ijerph19063302
pmc: PMC8951893
pii:
doi:
Substances chimiques
Amino Acids
0
Hyaluronic Acid
9004-61-9
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
J Tissue Eng Regen Med. 2019 Jun;13(6):1079-1092
pubmed: 30968584
Med Hypotheses. 2020 Sep;142:109746
pubmed: 32344287
J Pharm Sci. 2014 Aug;103(8):2414-23
pubmed: 24985030
Am J Pathol. 2012 Apr;180(4):1340-55
pubmed: 22387320
J Biomed Mater Res A. 2016 Jun;104(6):1560-9
pubmed: 27007721
Adv Wound Care (New Rochelle). 2013 May;2(4):122-141
pubmed: 24527336
Experientia. 1971 May 15;27(5):549-50
pubmed: 5132594
Int J Oral Maxillofac Implants. 2016 Nov/Dec;31(6):1397-1406
pubmed: 27861667
J Biol Regul Homeost Agents. 2008 Apr-Jun;22(2):109-16
pubmed: 18597703
Cell Adh Migr. 2019 Dec;13(1):23-32
pubmed: 29961420
Arch Oral Biol. 2014 Oct;59(10):1048-55
pubmed: 24973518
Int J Oral Maxillofac Surg. 2014 Nov;43(11):1399-403
pubmed: 24924267
Clin Exp Dermatol. 2012 Jul;37(5):516-20
pubmed: 22632105
Materials (Basel). 2019 Nov 09;12(22):
pubmed: 31717520
Antibiotics (Basel). 2022 Jan 17;11(1):
pubmed: 35052995
J Biol Regul Homeost Agents. 2019 Jan-Feb;33(1 Suppl. 1):55-59
pubmed: 30966733
Ann Rheum Dis. 1995 May;54(5):429-32
pubmed: 7794055
J Clin Periodontol. 2017 Feb;44(2):204-214
pubmed: 27883211
Int J Immunopathol Pharmacol. 2009 Apr-Jun;22(2):485-92
pubmed: 19505400
Med Oral Patol Oral Cir Bucal. 2020 Sep 1;25(5):e644-e651
pubmed: 32683390
Photomed Laser Surg. 2014 Jan;32(1):10-6
pubmed: 24328847
J Clin Med. 2022 Feb 10;11(4):
pubmed: 35207192
Medicina (Kaunas). 2021 Mar 18;57(3):
pubmed: 33803814
Med Hypotheses. 2017 Sep;107:22-25
pubmed: 28915955
Eur J Pharm Biopharm. 2019 Sep;142:498-505
pubmed: 31330258
J Clin Periodontol. 2003 Feb;30(2):159-64
pubmed: 12622859
J Tissue Eng Regen Med. 2018 Feb;12(2):e1088-e1097
pubmed: 28388010
J Adv Prosthodont. 2012 Aug;4(3):174-8
pubmed: 22977727
Minerva Stomatol. 2017 Aug;66(4):148-156
pubmed: 28569454
Am J Clin Dermatol. 2006;7(6):353-7
pubmed: 17173469