The Multifaceted Presentation of the Multisystem Inflammatory Syndrome in Children: Data from a Cluster Analysis.
COVID-19
cluster analysis
multisystem inflammatory syndrome in children (MIS-C)
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
21 Mar 2022
21 Mar 2022
Historique:
received:
17
01
2022
revised:
14
03
2022
accepted:
18
03
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
26
3
2022
Statut:
epublish
Résumé
The aim of this study was to evaluate the outcomes of patients with the multisystem inflammatory syndrome in children (MIS-C) according to phenotypes of disease and define the prognostic factors for the severe course. This cross-sectional study included 293 patients with MIS-C from seven pediatric rheumatology centers. A two-step cluster analysis was performed to define the spectrum of disease and their outcomes were compared between each group. Four subgroups were identified as follows: cluster I, predominantly Kawasaki-like features ( As shown, MIS-C is not a single disease presenting with various clinical features and outcomes. Understanding the disease spectrum will provide individualized management.
Sections du résumé
BACKGROUND
BACKGROUND
The aim of this study was to evaluate the outcomes of patients with the multisystem inflammatory syndrome in children (MIS-C) according to phenotypes of disease and define the prognostic factors for the severe course.
METHODS
METHODS
This cross-sectional study included 293 patients with MIS-C from seven pediatric rheumatology centers. A two-step cluster analysis was performed to define the spectrum of disease and their outcomes were compared between each group.
RESULTS
RESULTS
Four subgroups were identified as follows: cluster I, predominantly Kawasaki-like features (
CONCLUSION
CONCLUSIONS
As shown, MIS-C is not a single disease presenting with various clinical features and outcomes. Understanding the disease spectrum will provide individualized management.
Identifiants
pubmed: 35330065
pii: jcm11061742
doi: 10.3390/jcm11061742
pmc: PMC8950548
pii:
doi:
Types de publication
Journal Article
Langues
eng
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