Effectiveness of Prophylactic Human Cytomegalovirus Hyperimmunoglobulin in Preventing Cytomegalovirus Infection following Transplantation: A Systematic Review and Meta-Analysis.
CMV infection
CMVIG
cytomegalovirus
human CMV hyperimmunoglobulin
prophylaxis
transplantation
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
02 Mar 2022
02 Mar 2022
Historique:
received:
25
01
2022
revised:
18
02
2022
accepted:
28
02
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
26
3
2022
Statut:
epublish
Résumé
Cytomegalovirus (CMV) is a common infection occurring in patients undergoing solid organ transplantation (SOT) or hematopoietic stem cell transplantation (HSCT). CMV-specific hyperimmunoglobulin (CMVIG) has been used for the past four decades and is typically administered either prophylactically or pre-emptively. The present meta-analysis evaluated CMV infection rates in SOT patients who received prophylactic CMVIG. PubMed and the Cochrane Library were searched for studies published up to October 2021. The primary endpoint was CMV infection rate. Thirty-two SOT studies were identified (n = 1521 CMVIG-treated and n = 1196 controls). Prophylactic CMVIG treatment was often associated with a lower risk of CMV infection in transplant recipients. The average CMV infection rate was 35.8% (95% confidence interval [CI]: 33.4−38.2%) in patients treated prophylactically with CMVIG and 41.4% (95% CI: 38.6−44.2%) in the control group not receiving CMVIG (p = 0.003). Similar results were observed in analyses limited to publications evaluating currently available CMVIG products (Cytotect CP and Cytogam; p < 0.001). In combination with the established safety profile for CMVIG, these results suggest that prophylactic CMVIG treatment in patients undergoing solid organ transplantation may be beneficial, particularly in those at high risk of CMV infection or disease.
Identifiants
pubmed: 35330112
pii: life12030361
doi: 10.3390/life12030361
pmc: PMC8955988
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Biotest AG
ID : N/A
Références
Dtsch Med Wochenschr. 1987 May 22;112(21):827-31
pubmed: 3034541
Transplantation. 2019 Sep;103(9):1953-1963
pubmed: 30801548
Transplant Proc. 1990 Oct;22(5):2322-3
pubmed: 2171169
Clin Transplant. 2008 Jan-Feb;22(1):89-97
pubmed: 18217909
Transplant Proc. 1994 Oct;26(5 Suppl 1):23-7
pubmed: 7940972
Transplantation. 2006 May 27;81(10):1415-20
pubmed: 16732179
Infect Chemother. 2013 Sep;45(3):260-71
pubmed: 24396627
Transpl Int. 1993 Jan;6(1):34-8
pubmed: 8267694
Transpl Infect Dis. 2005 Jun;7(2):63-7
pubmed: 16150092
J Heart Lung Transplant. 2003 Jul;22(7):754-63
pubmed: 12873543
J Med Virol. 2021 Nov;93(11):6292-6300
pubmed: 33580523
J Heart Lung Transplant. 2009 Oct;28(10):1050-6
pubmed: 19782286
Cochrane Database Syst Rev. 2017 Jan 11;1:CD004759
pubmed: 28073178
Transplant Rev (Orlando). 2017 Apr;31(2):78-86
pubmed: 28131494
Am J Transplant. 2003 Apr;3(4):492-6
pubmed: 12694074
N Engl J Med. 1987 Oct 22;317(17):1049-54
pubmed: 2821397
J Heart Lung Transplant. 2003 Mar;22(3):250-7
pubmed: 12633691
Transplant Proc. 1993 Feb;25(1 Pt 2):1441-3
pubmed: 8382875
Transpl Int. 1998;11 Suppl 1:S130-4
pubmed: 9664962
Ann Intern Med. 1993 Nov 15;119(10):984-91
pubmed: 8214995
Bone Marrow Transplant. 1988 Nov;3(6):607-17
pubmed: 2850830
Transplant Proc. 1993 Dec;25(6):3256-8
pubmed: 8266533
Transpl Infect Dis. 2001;3 Suppl 2:1-5
pubmed: 11926743
Transpl Int. 2013 Jul;26(7):684-95
pubmed: 23656308
Haematol Blood Transfus. 1987;30:541-4
pubmed: 3040548
Open Forum Infect Dis. 2019 Jan 14;6(2):ofz003
pubmed: 30775403
J Heart Lung Transplant. 2005 Nov;24(11):1766-9
pubmed: 16297779
Transplantation. 1994 Feb 27;57(4):506-12
pubmed: 8116033
Am J Transplant. 2013 Oct;13(10):2601-10
pubmed: 23919557
Transplantation. 2016 Mar;100 Suppl 3:S11-8
pubmed: 26900990
BMJ. 1997 Sep 13;315(7109):629-34
pubmed: 9310563
Am J Transplant. 2017 Apr;17(4):856-879
pubmed: 28117944
J Clin Med. 2020 Feb 29;9(3):
pubmed: 32121313
Ann Transplant. 2015 Nov 05;20:661-6
pubmed: 26537426
Transplant Proc. 1991 Feb;23(1 Pt 2):1357-60
pubmed: 1846464
Transplantation. 1998 Dec 27;66(12):1682-8
pubmed: 9884259
Blood. 2004 Mar 15;103(6):2003-8
pubmed: 14644993
Rev Med Virol. 2019 May;29(3):e2034
pubmed: 30706584
Transplant Proc. 2001 Jun;33(4):2571-5
pubmed: 11406251
Clin Microbiol Rev. 2020 Oct 28;34(1):
pubmed: 33115722
Transplant Proc. 1996 Dec;28(6 Suppl 2):16
pubmed: 9037272
Transplantation. 1989 Aug;48(2):264-6
pubmed: 2547256
Int Immunopharmacol. 2014 Mar;19(1):142-4
pubmed: 24462495
Biol Blood Marrow Transplant. 2019 May;25(5):1022-1030
pubmed: 30639821
Transplant Proc. 2001 Feb-Mar;33(1-2):1811-2
pubmed: 11267523
Transplantation. 2010 Dec 27;90(12):1432-8
pubmed: 21076378
Lancet. 2000 Jun 10;355(9220):2032-6
pubmed: 10885354
Transplant Direct. 2021 Oct 22;7(11):e781
pubmed: 34712781
Nephron. 1999;81(3):368-9
pubmed: 10050103
Infection. 1993 Jul-Aug;21(4):195-200
pubmed: 8225620
Clin Microbiol Rev. 2013 Oct;26(4):703-27
pubmed: 24092851
Am J Transplant. 2008 May;8(5):913-4
pubmed: 18312610
Transplantation. 2016 Mar;100 Suppl 3:S1-4
pubmed: 26900989
Mediterr J Hematol Infect Dis. 2019 Sep 01;11(1):e2019048
pubmed: 31528314
Am J Transplant. 2019 Mar 18;:
pubmed: 30884079
JAMA. 1989 Jun 23-30;261(24):3607-9
pubmed: 2542634
Scand J Urol Nephrol Suppl. 1985;92:23-8
pubmed: 3008313
Transplant Proc. 1992 Feb;24(1):283-4
pubmed: 1311472
J Gen Virol. 2006 Jul;87(Pt 7):1763-1779
pubmed: 16760381
Transplantation. 2018 Jun;102(6):900-931
pubmed: 29596116
Lancet Haematol. 2016 Mar;3(3):e119-27
pubmed: 26947200
Chest. 1990 Feb;97(2):396-9
pubmed: 2153508