Genetic Workup for Charcot-Marie-Tooth Neuropathy: A Retrospective Single-Site Experience Covering 15 Years.

Charcot–Marie–Tooth (CMT) disease genetic neuropathy phenotype

Journal

Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444

Informations de publication

Date de publication:
10 Mar 2022
Historique:
received: 31 01 2022
revised: 04 03 2022
accepted: 07 03 2022
entrez: 25 3 2022
pubmed: 26 3 2022
medline: 26 3 2022
Statut: epublish

Résumé

Charcot-Marie-Tooth (CMT) disease is the most commonly inherited neurological disorder. This study includes patients affected by CMT during regular follow-ups at the CMT clinic in Genova, a neuromuscular university center in the northwest of Italy, with the aim of describing the genetic distribution of CMT subtypes in our cohort and reporting a peculiar phenotype. Since 2004, 585 patients (447 index cases) have been evaluated at our center, 64.9% of whom have a demyelinating neuropathy and 35.1% of whom have an axonal neuropathy. A genetic diagnosis was achieved in 66% of all patients, with the following distribution: CMT1A (48%), HNPP (14%), CMT1X (13%), CMT2A (5%), and P0-related neuropathies (7%), accounting all together for 87% of all the molecularly defined neuropathies. Interestingly, we observe a peculiar phenotype with initial exclusive lower limb involvement as well as lower limb involvement that is maintained over time, which we have defined as a "strictly length-dependent" phenotype. Most patients with this clinical presentation shared variants in either

Identifiants

pubmed: 35330153
pii: life12030402
doi: 10.3390/life12030402
pmc: PMC8948690
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Ministero della Salute
ID : Ricerca Corrente

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Auteurs

Chiara Gemelli (C)

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences (DINOGMI), University of Genova, 16126 Genova, Italy.
IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Alessandro Geroldi (A)

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences (DINOGMI), University of Genova, 16126 Genova, Italy.

Sara Massucco (S)

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences (DINOGMI), University of Genova, 16126 Genova, Italy.

Lucia Trevisan (L)

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences (DINOGMI), University of Genova, 16126 Genova, Italy.
IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Ilaria Callegari (I)

Department of Biomedicine, University Hospital Basel, University of Basel, 4001 Basel, Switzerland.

Lucio Marinelli (L)

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences (DINOGMI), University of Genova, 16126 Genova, Italy.
IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Giulia Ursino (G)

Unit of Neurology, ASL3 Villa Scassi Hospital, 16149 Genoa, Italy.

Mehrnaz Hamedani (M)

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences (DINOGMI), University of Genova, 16126 Genova, Italy.

Giulia Mennella (G)

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences (DINOGMI), University of Genova, 16126 Genova, Italy.

Silvia Stara (S)

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences (DINOGMI), University of Genova, 16126 Genova, Italy.
IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Giovanni Maggi (G)

IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Laura Mori (L)

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences (DINOGMI), University of Genova, 16126 Genova, Italy.
IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Cristina Schenone (C)

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences (DINOGMI), University of Genova, 16126 Genova, Italy.

Fabio Gotta (F)

IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Serena Patrone (S)

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences (DINOGMI), University of Genova, 16126 Genova, Italy.

Alessia Mammi (A)

IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Paola Origone (P)

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences (DINOGMI), University of Genova, 16126 Genova, Italy.
IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Valeria Prada (V)

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences (DINOGMI), University of Genova, 16126 Genova, Italy.
FISM, Fondazione Italiana Sclerosi Multipla, 16126 Genoa, Italy.

Lucilla Nobbio (L)

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences (DINOGMI), University of Genova, 16126 Genova, Italy.
IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Paola Mandich (P)

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences (DINOGMI), University of Genova, 16126 Genova, Italy.
IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Angelo Schenone (A)

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences (DINOGMI), University of Genova, 16126 Genova, Italy.
IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Emilia Bellone (E)

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences (DINOGMI), University of Genova, 16126 Genova, Italy.
IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Marina Grandis (M)

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences (DINOGMI), University of Genova, 16126 Genova, Italy.
IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Classifications MeSH