2-Fluorofucose Attenuates Hydrogen Peroxide-Induced Oxidative Stress in HepG2 Cells via Nrf2/keap1 and NF-κB Signaling Pathways.
2-fluorofucose
NF-κB
Nrf2
fucosylation
oxidative stress
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
11 Mar 2022
11 Mar 2022
Historique:
received:
25
01
2022
revised:
03
03
2022
accepted:
09
03
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
26
3
2022
Statut:
epublish
Résumé
Fucosylation is one of the most important glycan terminal modifications that affects multiple biological activities of proteins. 2-Fluorofucose (2FF), its specific inhibitor, has recently been reported to reveal numerous biological effects by blocking fucosylation both in vitro and in vivo. The current study aimed to evaluate the effect of 2FF on hydrogen peroxide (H
Identifiants
pubmed: 35330157
pii: life12030406
doi: 10.3390/life12030406
pmc: PMC8950221
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Natural Science Foundation of China
ID : 31500649
Organisme : Natural Science Foundation of Nantong City
ID : JC2019101
Références
Nat Chem Biol. 2012 Jul;8(7):661-8
pubmed: 22683610
Biochem Pharmacol. 2019 May;163:194-205
pubmed: 30779910
Mol Oncol. 2018 May;12(5):579-593
pubmed: 29215790
Free Radic Biol Med. 2018 Sep;125:15-24
pubmed: 29601945
PLoS One. 2015 Feb 23;10(2):e0117772
pubmed: 25706118
Biochem Pharmacol. 2010 Dec 15;80(12):1895-903
pubmed: 20643109
Redox Biol. 2017 Apr;11:613-619
pubmed: 28110218
Gastroenterology. 2018 Sep;155(3):629-647
pubmed: 30012333
J Biol Chem. 2003 Jun 27;278(26):24233-41
pubmed: 12711606
Mol Cancer Ther. 2012 Oct;11(10):2284-93
pubmed: 22902857
Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12669-74
pubmed: 21768335
Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5404-9
pubmed: 23493549
Cell Res. 2011 Jan;21(1):103-15
pubmed: 21187859
J Biochem Mol Toxicol. 2020 May;34(5):e22467
pubmed: 32040235
J Biochem Mol Toxicol. 2018 Oct;32(10):e22199
pubmed: 29992723
Oxid Med Cell Longev. 2016;2016:4350965
pubmed: 26998193
Biochem Biophys Res Commun. 2018 Jul 7;502(1):166-172
pubmed: 29792861
Acta Pharmacol Sin. 2021 Feb;42(2):230-241
pubmed: 32770173
Nat Rev Gastroenterol Hepatol. 2011 Feb;8(2):108-18
pubmed: 21293511
Nature. 2000 Nov 9;408(6809):239-47
pubmed: 11089981
Exp Mol Med. 2020 Feb;52(2):192-203
pubmed: 32060354
Annu Rev Biochem. 2017 Jun 20;86:715-748
pubmed: 28441057
Sci Rep. 2017 Sep 14;7(1):11563
pubmed: 28912543
Annu Rev Biochem. 2004;73:491-537
pubmed: 15189151
Biomolecules. 2019 Aug 19;9(8):
pubmed: 31430968
Free Radic Biol Med. 2020 May 20;152:116-141
pubmed: 32156524
Nat Rev Cancer. 2015 Sep;15(9):540-55
pubmed: 26289314
Nat Rev Mol Cell Biol. 2020 Feb;21(2):85-100
pubmed: 31636403
Hepatology. 2019 Apr;69(4):1768-1786
pubmed: 30561826
Cell Mol Life Sci. 2016 Sep;73(17):3221-47
pubmed: 27100828