Biased β-Agonists Favoring Gs over β-Arrestin for Individualized Treatment of Obstructive Lung Disease.
G protein
G-protein-coupled receptor kinases
airway smooth muscle
desensitization
tachyphylaxis
β2-adrenergic receptor
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
22 Feb 2022
22 Feb 2022
Historique:
received:
25
01
2022
revised:
14
02
2022
accepted:
17
02
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
26
3
2022
Statut:
epublish
Résumé
Signals from G-protein-coupled receptors (GPCRs) are the most frequently targeted pathways of currently prescribed therapeutics. Rather than being a simple switch, it is now evident that a given receptor can directly initiate multiple signals, and biasing to achieve signal selectivity based on agonist structure is possible. Biased agonists could direct therapeutically favorable pathways while avoiding counterproductive or adverse reaction pathways. For obstructive lung diseases, β
Identifiants
pubmed: 35330331
pii: jpm12030331
doi: 10.3390/jpm12030331
pmc: PMC8955194
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL114471
Pays : United States
Organisme : NIH HHS
ID : HL045967
Pays : United States
Organisme : NIH HHS
ID : HL114471
Pays : United States
Organisme : NIH HHS
ID : HL142992
Pays : United States
Références
Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3834-3839
pubmed: 29581292
J Biol Chem. 2006 Jan 13;281(2):1261-73
pubmed: 16280323
J Comb Chem. 2008 Jan-Feb;10(1):3-19
pubmed: 18067268
Nat Chem Biol. 2020 Aug;16(8):841-849
pubmed: 32367019
Am J Med. 2010 Apr;123(4):322-8.e2
pubmed: 20176343
J Med Chem. 2013 Dec 27;56(24):10103-17
pubmed: 24274400
Mol Syst Biol. 2012 Jun 26;8:590
pubmed: 22735336
Lancet. 2004 Oct 23-29;364(9444):1505-12
pubmed: 15500895
Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16346-16355
pubmed: 32601232
Sci Signal. 2020 Mar 31;13(625):
pubmed: 32234959
J Phys Chem Lett. 2021 Sep 30;12(38):9293-9300
pubmed: 34542294
J Biol Chem. 1998 Jul 24;273(30):18848-56
pubmed: 9668060
J Biol Chem. 2000 Sep 15;275(37):28989-93
pubmed: 10893245
Pharmacol Ther. 2022 Jan;229:107937
pubmed: 34174274
J Biol Chem. 1995 Oct 20;270(42):24753-60
pubmed: 7559592
Chest. 1996 Apr;109(4):953-6
pubmed: 8635376
Thorax. 1991 Feb;46(2):105-11
pubmed: 2014490
J Pain Res. 2019 Mar 11;12:927-943
pubmed: 30881102
Mediators Inflamm. 2021 Sep 15;2021:9412929
pubmed: 34566492
Mol Pharmacol. 1994 Apr;45(4):696-702
pubmed: 7910371
Clin Genet. 2014 Jul;86(1):12-20
pubmed: 24641588
J Biol Chem. 1992 Aug 5;267(22):15795-801
pubmed: 1322406
Sci Signal. 2011 Aug 9;4(185):pe36
pubmed: 21868354
Am J Respir Cell Mol Biol. 2006 Jul;35(1):55-64
pubmed: 16484685
Pharmacol Rev. 2019 Apr;71(2):267-315
pubmed: 30914442
Mol Pharmacol. 2011 Sep;80(3):367-77
pubmed: 21610196
Proc Natl Acad Sci U S A. 2021 Dec 7;118(49):
pubmed: 34857633
Molecules. 2013 May 30;18(6):6408-24
pubmed: 23722730
J Pharmacol Exp Ther. 2013 Mar;344(3):708-17
pubmed: 23300227
Thorax. 1996 Nov;51(11):1100-4
pubmed: 8958892
Nat Med. 2010 Nov;16(11):1299-304
pubmed: 20972434
J Struct Biol. 2010 Apr;170(1):10-20
pubmed: 20079848
J Biol Chem. 1996 Jul 26;271(30):18082-7
pubmed: 8663433
Thorax. 1995 May;50(5):497-504
pubmed: 7597661
Mol Pharmacol. 2022 Feb;101(2):87-94
pubmed: 34853152
Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):15007-12
pubmed: 19706446
Chest. 2006 Jan;129(1):15-26
pubmed: 16424409
Proteins. 2011 Jun;79(6):1878-97
pubmed: 21488099
Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):5836-5843
pubmed: 32127473
Life Sci Alliance. 2021 Dec 3;5(3):
pubmed: 34862271
Nat Rev Drug Discov. 2017 Dec;16(12):829-842
pubmed: 29075003
Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):5006-5015
pubmed: 32071246
J Pharmacol Exp Ther. 2010 Dec;335(3):572-9
pubmed: 20801892
Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62
pubmed: 17925438
Chembiochem. 2007 Sep 3;8(13):1527-39
pubmed: 17647204
Pharmacol Ther. 2019 Aug;200:148-178
pubmed: 31075355
Lancet. 1995 Jul 22;346(8969):201-6
pubmed: 7616798
Cell Signal. 2018 Jan;41:9-16
pubmed: 28137506
Nat Chem Biol. 2018 Nov;14(11):1059-1066
pubmed: 30327561