Genotoxic stress signalling as a driver of macrophage diversity.
ATM
ATR
DNA damage
chronic inflammation
innate immunity
macrophage programs
Journal
Cell stress
ISSN: 2523-0204
Titre abrégé: Cell Stress
Pays: Austria
ID NLM: 101718867
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
05
10
2021
revised:
19
01
2022
accepted:
24
01
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
26
3
2022
Statut:
epublish
Résumé
Tissue macrophages arise from yolk sac, fetal liver and hematopoietic progenitors and adopt diverse transcriptional programs and phenotypes, instructed by their microenvironment. In chronic inflammation, such as in chronic infections, autoimmunity, or cancer, tissue microenvironments change dramatically thus imprinting new programs on tissue macrophages. While stress is a known driver of carcinogenesis in epithelial cells, emerging evidence suggests that macrophage responses to genotoxic stress are embedded in their 'physiologic' immune and tissue healing programs and in most cases do not lead to myeloid malignancies. The role of genotoxic stress as an instructor of macrophage-mediated immune defense and tissue remodeling is only beginning to be understood. Here, we review the evidence showing that genotoxic stress, which macrophages and their precursors face upon encountering inflammatory and/or growth signals, instructs their transcriptional programs, by activating non-canonical, cell-type specific DNA Damage Response (DDR)-driven signaling pathways. We propose that immune-cell specific, DDR-instructed programs are crucial for tissue homeostasis as well as for the maintenance and resolution of inflammatory responses in infection, cancer, autoinflammatory and autoimmune microenvironments.
Identifiants
pubmed: 35330617
doi: 10.15698/cst2022.03.265
pii: CST0271E133
pmc: PMC8892193
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
30-44Informations de copyright
Copyright: © 2022 Kasapi and Triantafyllopoulou.
Déclaration de conflit d'intérêts
Conflict of Interest: The authors certify that they have no affiliations with or involvement in any organization or entity with any financial or non-financial interest in the subject matter or materials discussed in this manuscript.
Références
J Immunol. 2008 Feb 1;180(3):1432-41
pubmed: 18209038
Lab Invest. 2005 Apr;85(4):502-11
pubmed: 15711569
Cell. 2014 Aug 14;158(4):833-848
pubmed: 25126788
Nature. 2005 Apr 14;434(7035):907-13
pubmed: 15829965
EMBO Rep. 2017 Dec;18(12):2144-2159
pubmed: 29097394
Immunity. 2017 Dec 19;47(6):1210-1211
pubmed: 29262353
Nat Commun. 2013;4:1886
pubmed: 23695680
Immunity. 2013 Apr 18;38(4):792-804
pubmed: 23601688
Semin Immunopathol. 2015 Jul;37(4):349-57
pubmed: 25998914
Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):E5699-705
pubmed: 26371324
Annu Rev Pathol. 2020 Jan 24;15:123-147
pubmed: 31530089
Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4612-E4620
pubmed: 28533362
J Immunol. 2014 Aug 15;193(4):1988-97
pubmed: 25015816
Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10285-90
pubmed: 8816792
Nat Med. 2014 Aug;20(8):936-41
pubmed: 25038827
Cell. 2014 Dec 4;159(6):1327-40
pubmed: 25480297
Science. 2007 May 25;316(5828):1160-6
pubmed: 17525332
J Immunol. 2013 May 1;190(9):4736-41
pubmed: 23526823
Immunity. 2017 Sep 19;47(3):421-434.e3
pubmed: 28930658
Immunity. 2013 Jan 24;38(1):79-91
pubmed: 23273845
Blood. 2015 Nov 26;126(22):2502-10
pubmed: 26324700
Genes Dev. 2008 Feb 1;22(3):297-302
pubmed: 18245444
Annu Rev Immunol. 2015;33:643-75
pubmed: 25861979
Nature. 2019 Apr;568(7753):541-545
pubmed: 30971820
EMBO J. 2019 Oct 4;38(21):e102718
pubmed: 31544964
Front Genet. 2016 Oct 25;7:187
pubmed: 27826317
Science. 2003 Jun 6;300(5625):1542-8
pubmed: 12791985
Immunity. 2013 May 23;38(5):870-80
pubmed: 23706668
Nature. 2003 Jan 30;421(6922):499-506
pubmed: 12556884
Genes Dev. 2000 Jun 15;14(12):1448-59
pubmed: 10859164
Nature. 2018 May;557(7703):57-61
pubmed: 29670289
Sci Rep. 2016 Sep 28;6:34426
pubmed: 27677594
Cell Death Differ. 2017 Sep;24(9):1632-1644
pubmed: 28574504
Nat Cell Biol. 2020 Jan;22(1):49-59
pubmed: 31907410
Immunity. 2015 Feb 17;42(2):332-343
pubmed: 25692705
Nature. 2008 Dec 11;456(7223):819-23
pubmed: 18849970
PLoS One. 2012;7(9):e44156
pubmed: 22970173
Nature. 2017 Aug 24;548(7668):461-465
pubmed: 28738408
J Immunol. 2009 Sep 1;183(5):3229-36
pubmed: 19667093
Cell Rep. 2020 Mar 24;30(12):3972-3980.e5
pubmed: 32209460
J Exp Med. 2004 Feb 16;199(4):491-502
pubmed: 14769852
Sci Rep. 2018 Mar 7;8(1):4153
pubmed: 29515139
J Cell Biol. 2009 Feb 23;184(4):541-54
pubmed: 19237598
Nature. 2009 Oct 22;461(7267):1071-8
pubmed: 19847258
J Immunol. 1996 Jan 1;156(1):350-8
pubmed: 8598485
PLoS Genet. 2021 Apr 15;17(4):e1009523
pubmed: 33857133
Nat Commun. 2016 May 27;7:11752
pubmed: 27230542
J Virol. 2013 Dec;87(23):12949-56
pubmed: 24067963
Cell Rep. 2013 Apr 25;3(4):1036-43
pubmed: 23602554
Nat Rev Immunol. 2021 Jun;21(6):363-381
pubmed: 33340021
Cell Rep. 2017 Aug 22;20(8):1921-1935
pubmed: 28834754
J Immunol. 2015 Sep 1;195(5):1939-43
pubmed: 26223655
Nature. 2005 Aug 25;436(7054):1186-90
pubmed: 15995699
Nature. 2010 Nov 4;468(7320):98-102
pubmed: 20881962
Rheumatology (Oxford). 2008 Feb;47(2):165-71
pubmed: 18208821
J Immunol. 2016 Sep 15;197(6):2157-66
pubmed: 27511730
Trends Cell Biol. 2016 Jan;26(1):52-64
pubmed: 26437586
J Immunol. 2014 Jun 15;192(12):5993-7
pubmed: 24813208
Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):7993-8
pubmed: 9653128
Cell. 2014 Dec 4;159(6):1312-26
pubmed: 25480296
Cell. 1995 Mar 10;80(5):813-23
pubmed: 7889575
Cell. 2015 Aug 27;162(5):944-7
pubmed: 26317463
Science. 2013 Feb 15;339(6121):786-91
pubmed: 23258413
Cell. 2014 Sep 25;159(1):94-107
pubmed: 25259923
Cell. 2016 Nov 17;167(5):1264-1280.e18
pubmed: 28084216
J Clin Invest. 1998 Mar 15;101(6):1379-88
pubmed: 9502780
Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9302-6
pubmed: 18599436
Cell. 2011 Apr 1;145(1):92-103
pubmed: 21458669
Nature. 2011 May 25;474(7353):654-7
pubmed: 21613998
Trends Biochem Sci. 1998 Dec;23(12):469-72
pubmed: 9868367
J Pathol. 2018 Sep;246(1):12-40
pubmed: 29756349
Nat Immunol. 2012 Feb 12;13(3):223-228
pubmed: 22327569
Pharmacol Ther. 2015 Oct;154:36-56
pubmed: 26145166
Nature. 2018 Nov;563(7729):131-136
pubmed: 30356214
EMBO J. 2018 Jan 4;37(1):50-62
pubmed: 29084722
Anticancer Res. 2002 Nov-Dec;22(6C):4237-41
pubmed: 12553064
J Exp Med. 2016 Feb 8;213(2):209-23
pubmed: 26834154
Nat Rev Immunol. 2019 Apr;19(4):231-242
pubmed: 30778174
Mol Cell. 2010 Oct 22;40(2):179-204
pubmed: 20965415
Curr Opin Immunol. 2017 Dec;49:96-102
pubmed: 29128691
Nature. 2006 Nov 30;444(7119):633-7
pubmed: 17136093
Immunol Lett. 2000 Nov 1;74(3):221-4
pubmed: 11064105
Nat Rev Immunol. 2014 Feb;14(2):69-80
pubmed: 24378843
Nature. 2015 Feb 26;518(7540):547-51
pubmed: 25470051
Mol Cell. 2021 Feb 18;81(4):724-738.e9
pubmed: 33476576
Mol Cell. 2018 Sep 6;71(5):745-760.e5
pubmed: 30193098
Elife. 2017 Mar 31;6:
pubmed: 28362262
Cell. 2014 May 8;157(4):832-44
pubmed: 24792964
Nature. 2007 Feb 8;445(7128):656-60
pubmed: 17251933
Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3798-E3807
pubmed: 29610295
Nat Immunol. 2016 Jan;17(1):9-17
pubmed: 26681457
Cell. 2008 Aug 22;134(4):587-98
pubmed: 18724932
Nat Rev Immunol. 2015 Jul;15(7):429-40
pubmed: 26052098
J Cell Physiol. 2006 Sep;208(3):613-9
pubmed: 16741947
Cell. 2007 Nov 30;131(5):873-86
pubmed: 18045533
Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2969-74
pubmed: 23388631
Ann Rheum Dis. 2015 Mar;74(3):e17
pubmed: 24445253
Nat Rev Mol Cell Biol. 2014 Jul;15(7):482-96
pubmed: 24954210