Viewing Cortical Collecting Duct Function Through Phenotype-guided Single-Tubule Proteomics.
heterogeneity
intercalated cell
pendrin
plasticity
principal cell
proteomics
salt- and water transport
Journal
Function (Oxford, England)
ISSN: 2633-8823
Titre abrégé: Function (Oxf)
Pays: England
ID NLM: 101770668
Informations de publication
Date de publication:
2020
2020
Historique:
received:
26
05
2020
revised:
26
06
2020
accepted:
29
06
2020
entrez:
25
3
2022
pubmed:
2
7
2020
medline:
2
7
2020
Statut:
epublish
Résumé
The revolution of the omics technologies has enabled profiling of the molecules of any sample. However, the heterogeneity of the kidney with highly specialized nephron segments like the cortical collecting duct (CCD) poses a challenge regarding integration of omics data and functional analysis. We examined function and proteome from the same single CCDs of C57Bl6 mice by investigating them in a double-barreled perfusion system before targeted mass spectrometry. Transepithelial voltage (V
Identifiants
pubmed: 35330743
doi: 10.1093/function/zqaa007
pii: zqaa007
pmc: PMC8788781
doi:
Substances chimiques
Aquaporin 2
0
Proteome
0
Sulfate Transporters
0
Adenosine Triphosphatases
EC 3.6.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
zqaa007Commentaires et corrections
Type : CommentIn
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of the American Physiological Society 2020.
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