Mitochondrial P2X7 Receptor Localization Modulates Energy Metabolism Enhancing Physical Performance.

Animals Humans Mice Adenosine Triphosphate Energy Metabolism HEK293 Cells Physical Functional Performance Receptors, Purinergic P2X7 / genetics
P2X7 dilated cardiomyopathy extracellular ATP mitochondria oxidative phosphorylation purinergic signaling respiratory chain

Journal

Function (Oxford, England)
ISSN: 2633-8823
Titre abrégé: Function (Oxf)
Pays: England
ID NLM: 101770668

Informations de publication

Date de publication:
2021
Historique:
received: 17 12 2020
revised: 25 01 2021
accepted: 27 01 2021
entrez: 25 3 2022
pubmed: 28 1 2021
medline: 28 1 2021
Statut: epublish

Résumé

Basal expression of the P2X7 receptor (P2X7R) improves mitochondrial metabolism, Adenosine 5'-triphosphate (ATP) synthesis, and overall fitness of immune and non-immune cells. We investigated P2X7R contribution to energy metabolism and subcellular localization in fibroblasts (mouse embryo fibroblasts and HEK293 human fibroblasts), mouse microglia (primary brain microglia, and the N13 microglia cell line), and heart tissue. The P2X7R localizes to mitochondria, and its lack (1) decreases basal respiratory rate, ATP-coupled respiration, maximal uncoupled respiration, resting mitochondrial potential, mitochondrial matrix Ca

Identifiants

DOI: 10.1093/function/zqab005 PMID: 35330818 PMC: PMC8788778
pubmed: 35330818
doi: 10.1093/function/zqab005
pii: zqab005
pmc: PMC8788778
doi:

Substances chimiques

Adenosine Triphosphate 8L70Q75FXE
Receptors, Purinergic P2X7 0
P2rx7 protein, mouse 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Pagination

zqab005

Commentaires et corrections

Type : CommentIn
Type : ErratumIn

Informations de copyright

© The Author(s) 2021. Published by Oxford University Press on behalf of American Physiological Society.

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Auteurs

Alba Clara Sarti (AC)

Department of Medical Sciences, University of Ferrara, Ferrara 44121, Italy.

Valentina Vultaggio-Poma (V)

Department of Medical Sciences, University of Ferrara, Ferrara 44121, Italy.

Simonetta Falzoni (S)

Department of Medical Sciences, University of Ferrara, Ferrara 44121, Italy.

Sonia Missiroli (S)

Department of Medical Sciences, University of Ferrara, Ferrara 44121, Italy.

Anna Lisa Giuliani (AL)

Department of Medical Sciences, University of Ferrara, Ferrara 44121, Italy.

Paola Boldrini (P)

Center of Electronic Microscopy, University of Ferrara, Ferrara 44121, Italy.

Massimo Bonora (M)

Department of Medical Sciences, University of Ferrara, Ferrara 44121, Italy.

Francesco Faita (F)

Institute of Clinical Physiology, National Research Council, Pisa 56124, Italy.

Nicole Di Lascio (N)

Institute of Clinical Physiology, National Research Council, Pisa 56124, Italy.

Claudia Kusmic (C)

Institute of Clinical Physiology, National Research Council, Pisa 56124, Italy.

Anna Solini (A)

Department of Surgical, Medical, Molecular, and Critical Area Pathology, University of Pisa, Pisa 56124, Italy.

Salvatore Novello (S)

Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara 44121, Italy.

Michele Morari (M)

Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara 44121, Italy.

Marco Rossato (M)

Department of Medicine, University of Padova, Padova 35128, Italy.

Mariusz R Wieckowski (MR)

Nencki Institute of Experimental Biology, PAS, Warsaw 02093, Poland.

Carlotta Giorgi (C)

Department of Medical Sciences, University of Ferrara, Ferrara 44121, Italy.

Paolo Pinton (P)

Department of Medical Sciences, University of Ferrara, Ferrara 44121, Italy.

Francesco Di Virgilio (F)

Department of Medical Sciences, University of Ferrara, Ferrara 44121, Italy.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mitochondrial P2X7 Receptor Localization...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mitochondrial P2X7 Receptor Localization...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Mitochondrial P2X7 Receptor Localization...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Adénosine triphosphate › Mitochondrial P2X7 Receptor Localization...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Mitochondrial P2X7 Receptor Localization...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Mitochondrial P2X7 Receptor Localization...
questionsmedicales.fr › Caractéristiques de la population › Santé › Aptitude physique › Performance fonctionnelle physique › Mitochondrial P2X7 Receptor Localization...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs purinergiques › Récepteurs purinergiques P2 › Récepteurs purinergiques P2X › Récepteurs purinergiques P2X7 › Mitochondrial P2X7 Receptor Localization...