Early prone positioning in acute respiratory distress syndrome related to COVID-19: a propensity score analysis from the multicentric cohort COVID-ICU network-the ProneCOVID study.
Acute respiratory distress syndrome
COVID-19
Intensive care unit
Intubation
Mortality
Prone position
Journal
Critical care (London, England)
ISSN: 1466-609X
Titre abrégé: Crit Care
Pays: England
ID NLM: 9801902
Informations de publication
Date de publication:
24 03 2022
24 03 2022
Historique:
received:
13
09
2021
accepted:
14
03
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
31
3
2022
Statut:
epublish
Résumé
Delaying time to prone positioning (PP) may be associated with higher mortality in acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19). We evaluated the use and the impact of early PP on clinical outcomes in intubated patients hospitalized in intensive care units (ICUs) for COVID-19. All intubated patients with ARDS due to COVID-19 were involved in a secondary analysis from a prospective multicenter cohort study of COVID-ICU network including 149 ICUs across France, Belgium and Switzerland. Patients were followed-up until Day-90. The primary outcome was survival at Day-60. Analysis used a Cox proportional hazard model including a propensity score. Among 2137 intubated patients, 1504 (70.4%) were placed in PP during their ICU stay and 491 (23%) during the first 24 h following ICU admission. One hundred and eighty-one patients (36.9%) of the early PP group had a PaO In a large multicentric international cohort of intubated ICU patients with ARDS due to COVID-19, PP has been used frequently as a main treatment. In this study, our data failed to show a survival benefit associated with early PP started within 24 h after ICU admission compared to PP after day-1 for all COVID-19 patients requiring invasive mechanical ventilation regardless of their severity.
Sections du résumé
BACKGROUND
Delaying time to prone positioning (PP) may be associated with higher mortality in acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19). We evaluated the use and the impact of early PP on clinical outcomes in intubated patients hospitalized in intensive care units (ICUs) for COVID-19.
METHODS
All intubated patients with ARDS due to COVID-19 were involved in a secondary analysis from a prospective multicenter cohort study of COVID-ICU network including 149 ICUs across France, Belgium and Switzerland. Patients were followed-up until Day-90. The primary outcome was survival at Day-60. Analysis used a Cox proportional hazard model including a propensity score.
RESULTS
Among 2137 intubated patients, 1504 (70.4%) were placed in PP during their ICU stay and 491 (23%) during the first 24 h following ICU admission. One hundred and eighty-one patients (36.9%) of the early PP group had a PaO
CONCLUSIONS
In a large multicentric international cohort of intubated ICU patients with ARDS due to COVID-19, PP has been used frequently as a main treatment. In this study, our data failed to show a survival benefit associated with early PP started within 24 h after ICU admission compared to PP after day-1 for all COVID-19 patients requiring invasive mechanical ventilation regardless of their severity.
Identifiants
pubmed: 35331332
doi: 10.1186/s13054-022-03949-7
pii: 10.1186/s13054-022-03949-7
pmc: PMC8944409
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
71Investigateurs
Alain Mercat
(A)
Pierre Asfar
(P)
François Beloncle
(F)
Julien Demiselle
(J)
Tài Pham
(T)
Arthur Pavot
(A)
Xavier Monnet
(X)
Christian Richard
(C)
Alexandre Demoule
(A)
Martin Dres
(M)
Julien Mayaux
(J)
Alexandra Beurton
(A)
Cédric Daubin
(C)
Richard Descamps
(R)
Aurélie Joret
(A)
Damien Du Cheyron
(D)
Frédéric Pene
(F)
Jean-Daniel Chiche
(JD)
Mathieu Jozwiak
(M)
Paul Jaubert
(P)
Guillaume Voiriot
(G)
Muriel Fartoukh
(M)
Marion Teulier
(M)
Clarisse Blayau
(C)
Erwen L'Her
(E)
Cécile Aubron
(C)
Laetitia Bodenes
(L)
Nicolas Ferriere
(N)
Johann Auchabie
(J)
Anthony Le Meur
(A)
Sylvain Pignal
(S)
Thierry Mazzoni
(T)
Jean-Pierre Quenot
(JP)
Pascal Andreu
(P)
Jean-Baptiste Roudau
(JB)
Marie Labruyère
(M)
Saad Nseir
(S)
Sébastien Preau
(S)
Julien Poissy
(J)
Daniel Mathieu
(D)
Sarah Benhamida
(S)
Rémi Paulet
(R)
Nicolas Roucaud
(N)
Martial Thyrault
(M)
Florence Daviet
(F)
Sami Hraiech
(S)
Gabriel Parzy
(G)
Aude Sylvestre
(A)
Sébastien Jochmans
(S)
Anne-Laure Bouilland
(AL)
Mehran Monchi
(M)
Marc Danguy des Déserts
(MDD)
Quentin Mathais
(Q)
Gwendoline Rager
(G)
Pierre Pasquier
(P)
Reignier Jean
(R)
Seguin Amélie
(S)
Garret Charlotte
(G)
Canet Emmanuel
(C)
Jean Dellamonica
(J)
Clément Saccheri
(C)
Romain Lombardi
(R)
Yanis Kouchit
(Y)
Sophie Jacquier
(S)
Armelle Mathonnet
(A)
Mai-Ahn Nay
(MA)
Isabelle Runge
(I)
Frédéric Martino
(F)
Laure Flurin
(L)
Amélie Rolle
(A)
Michel Carles
(M)
Rémi Coudroy
(R)
Arnaud W Thille
(AW)
Jean-Pierre Frat
(JP)
Maeva Rodriguez
(M)
Pascal Beuret
(P)
Audrey Tientcheu
(A)
Arthur Vincent
(A)
Florian Michelin
(F)
Fabienne Tamion
(F)
Dorothée Carpentier
(D)
Déborah Boyer
(D)
Christophe Girault
(C)
Valérie Gissot
(V)
Stéphan Ehrmann
(S)
Charlotte Salmon Gandonniere
(CS)
Djlali Elaroussi
(D)
Agathe Delbove
(A)
Yannick Fedun
(Y)
Julien Huntzinger
(J)
Eddy Lebas
(E)
Grâce Kisoka
(G)
Céline Grégoire
(C)
Stella Marchetta
(S)
Bernard Lambermont
(B)
Laurent Argaud
(L)
Thomas Baudry
(T)
Pierre-Jean Bertrand
(PJ)
Auguste Dargent
(A)
Christophe Guitton
(C)
Nicolas Chudeau
(N)
Mickaël Landais
(M)
Cédric Darreau
(C)
Alexis Ferre
(A)
Antoine Gros
(A)
Guillaume Lacave
(G)
Fabrice Bruneel
(F)
Mathilde Neuville
(M)
Jérôme Devaquet
(J)
Guillaume Tachon
(G)
Richard Gallot
(R)
Riad Chelha
(R)
Arnaud Galbois
(A)
Anne Jallot
(A)
Ludivine Chalumeau Lemoine
(LC)
Khaldoun Kuteifan
(K)
Valentin Pointurier
(V)
Louise-Marie Jandeaux
(LM)
Joy Mootien
(J)
Charles Damoisel
(C)
Benjamin Sztrymf
(B)
Matthieu Schmidt
(M)
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(A)
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(J)
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(CE)
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(JM)
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(M)
Soizic Gergaud
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Pierre Lemarie
(P)
Nicolas Terzi
(N)
Carole Schwebel
(C)
Anaïs Dartevel
(A)
Louis-Marie Galerneau
(LM)
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(JL)
Caroline Hauw-Berlemont
(C)
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(N)
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(E)
Abolfazl Mohebbi Amoli
(AM)
Michel Benhamou
(M)
Jean-Pierre Deyme
(JP)
Olivier Andremont
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David Schnell
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Cécile Lory
(C)
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(T)
Vincent Bruckert
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Julie Garcia
(J)
Abdlazize Sahraoui
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Nathalie Abbosh
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(P)
Florent Poirson
(F)
Ahmed Pasem
(A)
Philippe Karoubi
(P)
Virginie Poupinel
(V)
Caroline Gauthier
(C)
François Bouniol
(F)
Philippe Feuchere
(P)
Florent Bavozet
(F)
Anne Heron
(A)
Serge Carreira
(S)
Malo Emery
(M)
Anne Sophie Le Floch
(AS)
Luana Giovannangeli
(L)
Nicolas Herzog
(N)
Christophe Giacardi
(C)
Thibaut Baudic
(T)
Chloé Thill
(C)
Said Lebbah
(S)
Jessica Palmyre
(J)
Florence Tubach
(F)
David Hajage
(D)
Nicolas Bonnet
(N)
Nathan Ebstein
(N)
Stéphane Gaudry
(S)
Yves Cohen
(Y)
Julie Noublanche
(J)
Olivier Lesieur
(O)
Arnaud Sément
(A)
Isabel Roca-Cerezo
(I)
Michel Pascal
(M)
Nesrine Sma
(N)
Gwenhaël Colin
(G)
Jean-Claude Lacherade
(JC)
Gauthier Bionz
(G)
Natacha Maquigneau
(N)
Pierre Bouzat
(P)
Michel Durand
(M)
Marie-Christine Hérault
(MC)
Jean-Francois Payen
(JF)
Informations de copyright
© 2022. The Author(s).
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