Sex differences in pain along the neuraxis.
Behavior
Neuroimmune signaling
Neurophysiology
Pain
Sex differences
Transcriptomics
Journal
Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217
Informations de publication
Date de publication:
01 06 2022
01 06 2022
Historique:
received:
23
11
2021
revised:
24
02
2022
accepted:
12
03
2022
pubmed:
26
3
2022
medline:
8
4
2022
entrez:
25
3
2022
Statut:
ppublish
Résumé
Despite the overwhelming female-predominance in chronic pain disorders, preclinical pain studies have historically excluded females as research subjects. Male-biased explanations of pathological pain mechanisms may not fully translate to pain processes in females, necessitating the exploration of pain processing and modulation in both sexes at the preclinical and clinical levels. This review highlights historical trends in the study of sex differences within the pain field and examines the current literature regarding new techniques for the mechanistic analysis of pain modulation in males and females. A large body of evidence suggests that sex differences exist at the molecular, cellular, and systems levels of pain processing, likely influenced by a combination of genetic, hormonal, and neuroimmune factors that may differ at distinct levels of the neuraxis.
Identifiants
pubmed: 35331712
pii: S0028-3908(22)00089-2
doi: 10.1016/j.neuropharm.2022.109030
pmc: PMC9354808
mid: NIHMS1827310
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
109030Subventions
Organisme : NINDS NIH HHS
ID : R01 NS118731
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS109255
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS038261
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS120395
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS106902
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
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