Effects of Apolipoprotein E polymorphism on carotid intima-media thickness, incident myocardial infarction and incident stroke.

Apolipoproteins E / genetics Carotid Intima-Media Thickness Humans Myocardial Infarction / epidemiology Plaque, Atherosclerotic Polymorphism, Genetic Risk Factors Stroke / epidemiology

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
24 03 2022
Historique:
received: 20 12 2021
accepted: 09 03 2022
entrez: 25 3 2022
pubmed: 26 3 2022
medline: 7 5 2022
Statut: epublish

Résumé

The Apolipoprotein E (APOE) gene polymorphism (rs429358 and rs7412) shows a well-established association with lipid profiles, but its effect on cardiovascular disease is still conflicting. Therefore, we examined the association of different APOE alleles with common carotid artery intima-media thickness (CCA-IMT), carotid plaques, incident myocardial infarction (MI) and stroke. We analyzed data from 3327 participants aged 20-79 years of the population-based Study of Health in Pomerania (SHIP) from Northeast Germany with a median follow-up time of 14.5 years. Linear, logistic, and Cox-regression models were used to assess the associations of the APOE polymorphism with CCA-IMT, carotid plaques, incident MI and stroke, respectively. In our study, the APOE E2 allele was associated with lower CCA-IMT at baseline compared to E3 homozygotes (β: - 0.02 [95% CI - 0.04, - 0.004]). Over the follow-up, 244 MI events and 218 stroke events were observed. APOE E2 and E4 allele were not associated with incident MI (E2 HR: 1.06 [95% CI 0.68, 1.66]; E4 HR: 1.03 [95% CI 0.73, 1.45]) and incident stroke (E2 HR: 0.79 [95% CI 0.48, 1.30]; E4 HR: 0.96 [95% CI 0.66, 1.38]) in any of the models adjusting for potential confounders. However, the positive association between CCA-IMT and incident MI was more pronounced in E2 carriers than E3 homozygotes. Thus, our study suggests that while APOE E2 allele may predispose individuals to lower CCA-IMT, E2 carriers may be more prone to MI than E3 homozygotes as the CCA-IMT increases. APOE E4 allele had no effect on CCA-IMT, plaques, MI or stroke.

Identifiants

DOI: 10.1038/s41598-022-09129-5 PMID: 35332187 PMC: PMC8948289
pubmed: 35332187
doi: 10.1038/s41598-022-09129-5
pii: 10.1038/s41598-022-09129-5
pmc: PMC8948289
doi:

Substances chimiques

ApoE protein, human 0
Apolipoproteins E 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5142

Informations de copyright

© 2022. The Author(s).

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Auteurs

Anitha Pitchika (A)

Institute for Community Medicine, University Medicine Greifswald, SHIP/Clinical-Epidemiological Research, Walther Rathenau Str. 48, 17475, Greifswald, Germany. anitha.pitchika@uni-greifswald.de.

Marcello Ricardo Paulista Markus (MRP)

Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
German Center for Cardiovascular Research (DZHK E.V.), Partner site Greifswald, Greifswald, Germany.
DZD (German Center for Diabetes Research), Site Greifswald, Greifswald, Germany.

Sabine Schipf (S)

Institute for Community Medicine, University Medicine Greifswald, SHIP/Clinical-Epidemiological Research, Walther Rathenau Str. 48, 17475, Greifswald, Germany.
Department of Medicine A, University Medicine Greifswald, Greifswald, Germany.

Alexander Teumer (A)

Institute for Community Medicine, University Medicine Greifswald, SHIP/Clinical-Epidemiological Research, Walther Rathenau Str. 48, 17475, Greifswald, Germany.
German Center for Cardiovascular Research (DZHK E.V.), Partner site Greifswald, Greifswald, Germany.

Sandra Van der Auwera (S)

Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.

Matthias Nauck (M)

German Center for Cardiovascular Research (DZHK E.V.), Partner site Greifswald, Greifswald, Germany.
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.

Marcus Dörr (M)

Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
German Center for Cardiovascular Research (DZHK E.V.), Partner site Greifswald, Greifswald, Germany.

Stephan Felix (S)

Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
German Center for Cardiovascular Research (DZHK E.V.), Partner site Greifswald, Greifswald, Germany.

Hans-Jörgen Grabe (HJ)

Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.

Henry Völzke (H)

Institute for Community Medicine, University Medicine Greifswald, SHIP/Clinical-Epidemiological Research, Walther Rathenau Str. 48, 17475, Greifswald, Germany.
German Center for Cardiovascular Research (DZHK E.V.), Partner site Greifswald, Greifswald, Germany.
DZD (German Center for Diabetes Research), Site Greifswald, Greifswald, Germany.

Till Ittermann (T)

Institute for Community Medicine, University Medicine Greifswald, SHIP/Clinical-Epidemiological Research, Walther Rathenau Str. 48, 17475, Greifswald, Germany.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Apolipoprotéines E › Effects of Apolipoprotein E polymorphism on...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Épaisseur intima-média carotidienne › Effects of Apolipoprotein E polymorphism on...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Effects of Apolipoprotein E polymorphism on...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Infarctus › Infarctus du myocarde › Effects of Apolipoprotein E polymorphism on...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Plaque d'athérosclérose › Effects of Apolipoprotein E polymorphism on...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Effects of Apolipoprotein E polymorphism on...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Effects of Apolipoprotein E polymorphism on...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Effects of Apolipoprotein E polymorphism on...