Nigratine as dual inhibitor of necroptosis and ferroptosis regulated cell death.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
24 03 2022
24 03 2022
Historique:
received:
23
03
2021
accepted:
14
03
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
6
5
2022
Statut:
epublish
Résumé
Nigratine (also known as 6E11), a flavanone derivative of a plant natural product, was characterized as highly specific non-ATP competitive inhibitor of RIPK1 kinase, one of the key components of necroptotic cell death signaling. We show here that nigratine inhibited both necroptosis (induced by Tumor Necrosis Factor-α) and ferroptosis (induced by the small molecules glutamate, erastin, RSL3 or cumene hydroperoxide) with EC
Identifiants
pubmed: 35332201
doi: 10.1038/s41598-022-09019-w
pii: 10.1038/s41598-022-09019-w
pmc: PMC8944179
doi:
Substances chimiques
Tumor Necrosis Factor-alpha
0
Receptor-Interacting Protein Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5118Informations de copyright
© 2022. The Author(s).
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