Brain connectivity fingerprinting and behavioural prediction rest on distinct functional systems of the human connectome.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
24 03 2022
24 03 2022
Historique:
received:
17
03
2021
accepted:
08
02
2022
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
13
4
2022
Statut:
epublish
Résumé
The prediction of inter-individual behavioural differences from neuroimaging data is a rapidly evolving field of research focusing on individualised methods to describe human brain organisation on the single-subject level. One method that harnesses such individual signatures is functional connectome fingerprinting, which can reliably identify individuals from large study populations. However, the precise relationship between functional signatures underlying fingerprinting and behavioural prediction remains unclear. Expanding on previous reports, here we systematically investigate the link between discrimination and prediction on different levels of brain network organisation (individual connections, network interactions, topographical organisation, and connection variability). Our analysis revealed a substantial divergence between discriminatory and predictive connectivity signatures on all levels of network organisation. Across different brain parcellations, thresholds, and prediction algorithms, we find discriminatory connections in higher-order multimodal association cortices, while neural correlates of behaviour display more variable distributions. Furthermore, we find the standard deviation of connections between participants to be significantly higher in fingerprinting than in prediction, making inter-individual connection variability a possible separating marker. These results demonstrate that participant identification and behavioural prediction involve highly distinct functional systems of the human connectome. The present study thus calls into question the direct functional relevance of connectome fingerprints.
Identifiants
pubmed: 35332230
doi: 10.1038/s42003-022-03185-3
pii: 10.1038/s42003-022-03185-3
pmc: PMC8948277
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
261Informations de copyright
© 2022. The Author(s).
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