Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) syndrome: Treatment approach depends on disease course.
CLIPPERS
autoimmune disorders
brainstem
corticosteroids
ocrelizumab
Journal
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
ISSN: 1804-7521
Titre abrégé: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
Pays: Czech Republic
ID NLM: 101140142
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
03
01
2022
accepted:
14
03
2022
medline:
3
11
2023
pubmed:
26
3
2022
entrez:
25
3
2022
Statut:
ppublish
Résumé
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a rare inflammatory central nervous system (CNS) disorder, chiefly involving the brainstem, especially the pons. The diagnosis is challenging, requires careful exclusion of alternative diagnoses and a targeted therapeutic approach. CLIPPERS is known to respond well to corticosteroids, but the treatment needs to be long-term and can cause significant side-effects. Moreover, subsequent corticosteroid withdrawal often leads to a relapse. It has been suggested that anti-CD20 molecules could benefit several antibody-mediated CNS inflammatory diseases, including CLIPPERS. This paper describes two cases of CLIPPERS. The first demonstrates the benefit of early introduction of corticosteroids with side effects in cases of long-term use. The second demonstrates the efficacy of ocrelizumab (anti-CD20 molecule) in a severe course of CLIPPERS. These two cases bring attention to this rare, often misdiagnosed but treatable disease.
Substances chimiques
Steroids
0
Adrenal Cortex Hormones
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
303-308Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
Références
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