Association of Genetic Ancestry With Terminal Duct Lobular Unit Involution Among Healthy Women.
Journal
Journal of the National Cancer Institute
ISSN: 1460-2105
Titre abrégé: J Natl Cancer Inst
Pays: United States
ID NLM: 7503089
Informations de publication
Date de publication:
06 10 2022
06 10 2022
Historique:
received:
09
11
2021
revised:
31
01
2022
accepted:
16
03
2022
pubmed:
26
3
2022
medline:
13
10
2022
entrez:
25
3
2022
Statut:
ppublish
Résumé
Reduced age-related terminal duct lobular unit (TDLU) involution has been linked to increased breast cancer risk and triple-negative breast cancer. Associations of TDLU involution levels with race and ethnicity remain incompletely explored. Herein, we examined the association between genetic ancestry and TDLU involution in normal breast tissue donated by 2014 healthy women in the United States. Women of African ancestry were more likely than European women to have increased TDLU counts (odds ratio [OR]trend = 1.36, 95% confidence interval [CI] = 1.07 to 1.74), acini counts per TDLU (OR = 1.47, 95% CI = 1.06 to 2.03), and median TDLU span (ORtrend = 1.44, 95% CI = 1.08 to 1.91), indicating lower involution, whereas East Asian descendants were associated with decreased TDLU counts (ORtrend = 0.52, 95% CI = 0.35 to 0.78) after controlling for potential confounders. These associations are consistent with the racial variations in incidence rates of triple-negative breast cancer in the United States and suggest opportunities for future work examining whether TDLU involution may mediate the racial differences in subtype-specific breast cancer risk.
Identifiants
pubmed: 35333343
pii: 6554202
doi: 10.1093/jnci/djac063
pmc: PMC9552305
doi:
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1420-1424Subventions
Organisme : Intramural Research Program of the Division of Cancer Epidemiology and Genetics, National Cancer Institute
Informations de copyright
Published by Oxford University Press 2022. This work is written by US Government employees and is in the public domain in the US.
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