Decision flexibilities in autism spectrum disorder: an fMRI study of moral dilemmas.
autism spectrum disorder
flexibility
functional magnetic resonance imaging
inferior frontal gyrus
moral dilemma
Journal
Social cognitive and affective neuroscience
ISSN: 1749-5024
Titre abrégé: Soc Cogn Affect Neurosci
Pays: England
ID NLM: 101288795
Informations de publication
Date de publication:
03 10 2022
03 10 2022
Historique:
received:
28
08
2021
revised:
07
02
2022
accepted:
24
03
2022
pubmed:
26
3
2022
medline:
5
10
2022
entrez:
25
3
2022
Statut:
ppublish
Résumé
People make flexible decisions across a wide range of contexts to resolve social or moral conflicts. Individuals with autism spectrum disorder (ASD) frequently report difficulties in such behaviors, which hinders the flexibility in changing strategies during daily activities or adjustment of perspective during communication. However, the underlying mechanisms of this issue are insufficiently understood. This study aimed to investigate decision flexibility in ASD using a functional magnetic resonance imaging task that involved recognizing and resolving two types of moral dilemmas: cost-benefit analysis (CBA) and mitigating inevitable misconducts (MIM). The CBA session assessed the participants' pitting of result-oriented outcomes against distressful harmful actions, whereas the MIM session assessed their pitting of the extenuation of a criminal sentence against a sympathetic situation of defendants suffering from violence or disease. The behavioral outcome in CBA-related flexibility was significantly lower in the ASD group compared to that of the typical development group. In the corresponding CBA contrast, activation in the left inferior frontal gyrus was lower in the ASD group. Meanwhile, in the MIM-related flexibility, there were no significant group differences in behavioral outcome or brain activity. Our findings add to our understanding of flexible decision-making in ASD.
Identifiants
pubmed: 35333369
pii: 6554182
doi: 10.1093/scan/nsac023
pmc: PMC9527470
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
904-911Informations de copyright
© The Author(s) 2022. Published by Oxford University Press.
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