Nuclear HMGB1 protects from nonalcoholic fatty liver disease through negative regulation of liver X receptor.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
25 Mar 2022
25 Mar 2022
Historique:
entrez:
25
3
2022
pubmed:
26
3
2022
medline:
26
3
2022
Statut:
ppublish
Résumé
Dysregulations of lipid metabolism in the liver may trigger steatosis progression, leading to potentially severe clinical consequences such as nonalcoholic fatty liver diseases (NAFLDs). Molecular mechanisms underlying liver lipogenesis are very complex and fine-tuned by chromatin dynamics and multiple key transcription factors. Here, we demonstrate that the nuclear factor HMGB1 acts as a strong repressor of liver lipogenesis. Mice with liver-specific
Identifiants
pubmed: 35333579
doi: 10.1126/sciadv.abg9055
pmc: PMC8956270
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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