Gene losses in the common vampire bat illuminate molecular adaptations to blood feeding.


Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
25 03 2022
Historique:
entrez: 25 3 2022
pubmed: 26 3 2022
medline: 7 4 2022
Statut: ppublish

Résumé

Vampire bats are the only mammals that feed exclusively on blood. To uncover genomic changes associated with this dietary adaptation, we generated a haplotype-resolved genome of the common vampire bat and screened 27 bat species for genes that were specifically lost in the vampire bat lineage. We found previously unknown gene losses that relate to reduced insulin secretion (

Identifiants

pubmed: 35333583
doi: 10.1126/sciadv.abm6494
pmc: PMC8956264
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabm6494

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Auteurs

Moritz Blumer (M)

Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.
Max Planck Institute for the Physics of Complex Systems, 01187 Dresden, Germany.
Center for Systems Biology Dresden, 01307 Dresden, Germany.
Goethe University, Faculty of Biosciences, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany.

Tom Brown (T)

Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.

Mariella Bontempo Freitas (MB)

Department of Animal Biology, Federal University of Viçosa, Viçosa, Brazil.

Ana Luiza Destro (AL)

Department of Animal Biology, Federal University of Viçosa, Viçosa, Brazil.

Juraci A Oliveira (JA)

Department of General Biology, Federal University of Viçosa, Viçosa, Brazil.

Ariadna E Morales (AE)

Goethe University, Faculty of Biosciences, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany.
LOEWE Centre for Translational Biodiversity Genomics, Senckenberganlage 25, 60325 Frankfurt, Germany.
Senckenberg Research Institute, Senckenberganlage 25, 60325 Frankfurt, Germany.

Tilman Schell (T)

LOEWE Centre for Translational Biodiversity Genomics, Senckenberganlage 25, 60325 Frankfurt, Germany.
Senckenberg Research Institute, Senckenberganlage 25, 60325 Frankfurt, Germany.

Carola Greve (C)

LOEWE Centre for Translational Biodiversity Genomics, Senckenberganlage 25, 60325 Frankfurt, Germany.
Senckenberg Research Institute, Senckenberganlage 25, 60325 Frankfurt, Germany.

Martin Pippel (M)

Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.

David Jebb (D)

Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.
Max Planck Institute for the Physics of Complex Systems, 01187 Dresden, Germany.
Center for Systems Biology Dresden, 01307 Dresden, Germany.

Nikolai Hecker (N)

Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.
Max Planck Institute for the Physics of Complex Systems, 01187 Dresden, Germany.
Center for Systems Biology Dresden, 01307 Dresden, Germany.

Alexis-Walid Ahmed (AW)

Goethe University, Faculty of Biosciences, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany.
LOEWE Centre for Translational Biodiversity Genomics, Senckenberganlage 25, 60325 Frankfurt, Germany.
Senckenberg Research Institute, Senckenberganlage 25, 60325 Frankfurt, Germany.

Bogdan M Kirilenko (BM)

Goethe University, Faculty of Biosciences, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany.
LOEWE Centre for Translational Biodiversity Genomics, Senckenberganlage 25, 60325 Frankfurt, Germany.
Senckenberg Research Institute, Senckenberganlage 25, 60325 Frankfurt, Germany.

Maddy Foote (M)

Native Bat Conservation Program, Toronto Zoo, 361A Old Finch Avenue, Toronto, Ontario M1B 5K7, Canada.

Axel Janke (A)

LOEWE Centre for Translational Biodiversity Genomics, Senckenberganlage 25, 60325 Frankfurt, Germany.
Senckenberg Biodiversity and Climate Research Centre, Senckenberganlage 25, 60325 Frankfurt am Main, Germany.

Burton K Lim (BK)

Department of Natural History, Royal Ontario Museum, 100 Queen's Park, Toronto, Ontario M5S 2C6, Canada.

Michael Hiller (M)

Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.
Max Planck Institute for the Physics of Complex Systems, 01187 Dresden, Germany.
Center for Systems Biology Dresden, 01307 Dresden, Germany.
Goethe University, Faculty of Biosciences, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany.
LOEWE Centre for Translational Biodiversity Genomics, Senckenberganlage 25, 60325 Frankfurt, Germany.
Senckenberg Research Institute, Senckenberganlage 25, 60325 Frankfurt, Germany.

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Classifications MeSH