Toxicology and pharmacology of botulinum and tetanus neurotoxins: an update.
Botulism
Cholinergic
Neurotoxins
Tetanus
Therapy
Toxicity
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
10
12
2021
accepted:
28
02
2022
pubmed:
26
3
2022
medline:
18
5
2022
entrez:
25
3
2022
Statut:
ppublish
Résumé
Tetanus and botulinum neurotoxins cause the neuroparalytic syndromes of tetanus and botulism, respectively, by delivering inside different types of neurons, metalloproteases specifically cleaving the SNARE proteins that are essential for the release of neurotransmitters. Research on their mechanism of action is intensively carried out in order to devise improved therapies based on antibodies and chemical drugs. Recently, major results have been obtained with human monoclonal antibodies and with single chain antibodies that have allowed one to neutralize the metalloprotease activity of botulinum neurotoxin type A1 inside neurons. In addition, a method has been devised to induce a rapid molecular evolution of the metalloprotease domain of botulinum neurotoxin followed by selection driven to re-target the metalloprotease activity versus novel targets with respect to the SNARE proteins. At the same time, an intense and wide spectrum clinical research on novel therapeutics based on botulinum neurotoxins is carried out, which are also reviewed here.
Identifiants
pubmed: 35333944
doi: 10.1007/s00204-022-03271-9
pii: 10.1007/s00204-022-03271-9
pmc: PMC9095541
doi:
Substances chimiques
Neurotoxins
0
SNARE Proteins
0
Botulinum Toxins, Type A
EC 3.4.24.69
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1521-1539Informations de copyright
© 2022. The Author(s).
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