Factors affecting health-related quality of life in older patients with chronic kidney disease: a single-center cross-sectional study.
EuroQoL 5-dimension 5-level
Physical function
Predialysis
Renal function
Short physical performance battery
Journal
International urology and nephrology
ISSN: 1573-2584
Titre abrégé: Int Urol Nephrol
Pays: Netherlands
ID NLM: 0262521
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
08
10
2021
accepted:
15
03
2022
pubmed:
26
3
2022
medline:
14
9
2022
entrez:
25
3
2022
Statut:
ppublish
Résumé
Health-related quality of life (HRQoL) assessment is important for patients with chronic kidney disease (CKD). However, few studies have examined factors related to HRQoL, such as physical function, in older patients with predialysis CKD. This study evaluated the relationship between physical function, renal function, and nutritional status on the HRQoL in this patient group. This cross-sectional study included 61 patients aged ≥ 65 years with stages 3-5 predialysis CKD who were admitted for CKD education purposes. Using the EuroQoL 5-dimension 5-level (EQ-5D-5L) health status measure, the percentages of each EQ-5D-5L item were investigated. Physical function was measured using the short physical performance battery (SPPB) and grip strength, and characteristics, such as age, sex, diabetes mellitus, estimated glomerular filtration rate, and Geriatric Nutrition Risk Index, were investigated. Factors associated with EQ-5D-5L were identified using multiple regression analysis. More than half of respondents (34/61, 55.7%) selected the second or higher level "have a problem" for the pain/discomfort section. The EQ-5D-5L score was significantly correlated with grip strength (r = 0.34, p = 0.01) and SPPB (r = 0.59, p = 0.00) in a single correlation analysis. Only SPPB (β = 0.67, p = 0.00) remained a significant factor after adjustment for grip strength, SPPB, age, sex, diabetes mellitus, and estimated glomerular filtration rate. Physical function may be an important factor influencing HRQoL in older patients with predialysis CKD.
Sections du résumé
BACKGROUND
BACKGROUND
Health-related quality of life (HRQoL) assessment is important for patients with chronic kidney disease (CKD). However, few studies have examined factors related to HRQoL, such as physical function, in older patients with predialysis CKD. This study evaluated the relationship between physical function, renal function, and nutritional status on the HRQoL in this patient group.
METHODS
METHODS
This cross-sectional study included 61 patients aged ≥ 65 years with stages 3-5 predialysis CKD who were admitted for CKD education purposes. Using the EuroQoL 5-dimension 5-level (EQ-5D-5L) health status measure, the percentages of each EQ-5D-5L item were investigated. Physical function was measured using the short physical performance battery (SPPB) and grip strength, and characteristics, such as age, sex, diabetes mellitus, estimated glomerular filtration rate, and Geriatric Nutrition Risk Index, were investigated. Factors associated with EQ-5D-5L were identified using multiple regression analysis.
RESULTS
RESULTS
More than half of respondents (34/61, 55.7%) selected the second or higher level "have a problem" for the pain/discomfort section. The EQ-5D-5L score was significantly correlated with grip strength (r = 0.34, p = 0.01) and SPPB (r = 0.59, p = 0.00) in a single correlation analysis. Only SPPB (β = 0.67, p = 0.00) remained a significant factor after adjustment for grip strength, SPPB, age, sex, diabetes mellitus, and estimated glomerular filtration rate.
CONCLUSION
CONCLUSIONS
Physical function may be an important factor influencing HRQoL in older patients with predialysis CKD.
Identifiants
pubmed: 35334064
doi: 10.1007/s11255-022-03180-x
pii: 10.1007/s11255-022-03180-x
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2637-2643Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature B.V.
Références
Stevens LA, Li S, Wang C et al (2010) Prevalence of CKD and comorbid illness in elderly patients in the United States: results from the Kidney Early Evaluation Program (KEEP). Am J Kidney Dis 55:S23–S33
pubmed: 20172445
pmcid: 4574484
Lee S, Lee S, Bae S et al (2018) Relationship between chronic kidney disease, without diabetes mellitus and components of frailty in community-elling Japanese older adults. Geriatr Gerontol Int 18:286–292
pubmed: 29052935
Ishikawa S, Naito S, Iimori S et al (2018) Loop diuretics are associated with greater risk of sarcopenia in patients with non-dialysis-dependent chronic kidney disease. PLoS ONE 13:e0192990
pubmed: 29447254
pmcid: 5814019
Windahl K, Irving GF, Almquist T et al (2018) Prevalence and risk of protein-energy wasting assessed by subjective global assessment in older adults with advanced chronic kidney disease: results from the EQUAL study. J Ren Nutr 28:165–174
pubmed: 29459026
Otobe Y, Hiraki K, Hotta C et al (2019) Mild cognitive impairment in older adults with pre-dialysis patients with chronic kidney disease: prevalence and association with physical function. Nephrology 24:50–55
pubmed: 28949427
Aiyegbusi OL, Kyte D, Cockwell P et al (2017) Measurement properties of patient-reported outcome measures (PROMs) used in adult patients with chronic kidney disease: a systematic review. PLoS ONE 12:e0179733
pubmed: 28636678
pmcid: 5479575
de Goeij MC, Ocak G, Rotmans JI et al (2014) Course of symptoms and health-related quality of life during specialized predialysis care. PLoS ONE 9:e93069
pubmed: 24699666
pmcid: 3974712
Porter AC, Lash JP, Xie D et al (2016) Predictors and outcomes of health-related quality of life in adults with CKD. Clin J Am Soc Nephrol 11:1154–1162
pubmed: 27246012
pmcid: 4934840
Tsai YC, Hung CC, Hwang SJ et al (2010) Quality of life predicts risks of end-stage renal disease and mortality in patients with chronic kidney disease. Nephrol Dial Transpl 25:1621–1626
Chin HJ, Song YR, Lee JJ et al (2008) Moderately decreased renal function negatively affects the health-related quality of life among the elderly Korean population: a population-based study. Nephrol Dial Transpl 23:2810–2817
Pagels AA, Soderkvist BK, Medin C et al (2012) Health-related quality of life in different stages of chronic kidney disease and at initiation of dialysis treatment. Health Qual Life Outcomes 10:71
pubmed: 22710013
pmcid: 3511211
Kefale B, Alebachew M, Tadesse Y et al (2019) Quality of life and its predictors among patients with chronic kidney disease: a hospital-based cross sectional study. PLoS ONE 14:e0212184
pubmed: 30811447
pmcid: 6392259
Tajima R, Kondo M, Kai H et al (2010) Measurement of health-related quality of life in patients with chronic kidney disease in Japan with EuroQol (EQ-5D). Clin Exp Nephrol 14:340–348
pubmed: 20567874
Nixon AC, Bampouras TM, Pendleton N et al (2020) Frailty is independently associated with worse health-related quality of life in chronic kidney disease: a secondary analysis of the Frailty Assessment in Chronic Kidney Disease study. Clin Kidney J 13:85–94
pubmed: 32083613
Gravina EPL, Pinheiro BV, Jesus LAS et al (2021) Factors associated with functional capacity in CKD patients. Clin Nurs Res 30:351–359
pubmed: 32959669
Roshanravan B, Robinson-Cohen C, Patel KV et al (2013) Association between physical performance and all-cause mortality in CKD. J Am Soc Nephrol 24:822–830
pubmed: 23599380
pmcid: 3636794
Gregg LP, Jain N, Carmody T et al (2019) Fatigue in nondialysis chronic kidney disease: correlates and association with kidney outcomes. Am J Nephrol 50:37–47
pubmed: 31167183
Loosman WL, Rottier MA, Honig A et al (2015) Association of depressive and anxiety symptoms with adverse events in Dutch chronic kidney disease patients: a prospective cohort study. BMC Nephrol 16:155
pubmed: 26390864
pmcid: 4578821
Bowling CB, Vandenberg AE, Phillips LS et al (2017) Older patients’ perspectives on managing complexity in CKD self-management. Clin J Am Soc Nephrol 12:635–643
pubmed: 28389529
pmcid: 5383384
Shimizu U, Aoki H, Sakagami M et al (2018) Walking ability, anxiety and depression, significantly decrease EuroQol 5-Dimension 5-Level scores in older hemodialysis patients in Japan. Arch Gerontol Geriatr 78:96–100
pubmed: 29936330
Bouillanne O, Morineau G, Dupont C et al (2005) Geriatric Nutritional Risk Index: a new index for evaluating at-risk elderly medical patients. Am J Clin Nutr 82:777–783
pubmed: 16210706
Shiroiwa T, Ikeda S, Noto S et al (2016) Comparison of value set based on DCE and/or TTO data: scoring for EQ-5D-5L health states in Japan. Value Health 19:648–654
pubmed: 27565282
Shiroiwa T, Fukuda T, Ikeda S et al (2016) Japanese population norms for preference-based measures: EQ-5D-3L, EQ-5D-5L, and SF-6D. Qual Life Res 25:707–719
pubmed: 26303761
Oh B, Cho B, Choi HC et al (2014) The influence of lower-extremity function in elderly individuals’ quality of life (QOL): an analysis of the correlation between SPPB and EQ-5D. Arch Gerontol Geriatr 58:278–282
pubmed: 24275121
Tanaka S, Ando K, Kobayashi K et al (2021) The dual presence of frailty and locomotive syndrome is associated with a greater decrease in the EQ-5D-5L index. Nagoya J Med Sci 83:159–167
pubmed: 33727747
pmcid: 7938103
Krishnan A, Teixeira-Pinto A, Lim WH et al (2020) Health-related quality of life in people across the spectrum of CKD. Kidney Int Rep 5:2264–2274
pubmed: 33305120
pmcid: 7710842
Guralnik JM, Simonsick EM, Ferrucci L et al (1994) A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol 49:M85–M94
pubmed: 8126356
Westman AW, Combs-Miller S, Moore J et al (2019) Measurement characteristics and clinical utility of the short physical performance battery among community-dwelling older adults. Arch Phys Med Rehabil 100:185–187
Mijnarends DM, Meijers JM, Halfens RJ et al (2013) Validity and reliability of tools to measure muscle mass, strength, and physical performance in community-dwelling older people: a systematic review. J Am Med Dir Assoc 14:170–178
pubmed: 23276432
Reese PP, Cappola AR, Shults J et al (2013) CRIC Study Investigators: physical performance and frailty in chronic kidney disease. Am J Nephrol 38:307–315
pubmed: 24107579
Nogueira Á, Álvarez G, Russo F et al (2019) Is SPPB useful as a screening method of functional capacity in patients with advanced chronic kidney disease? Nefrologia (Engl Ed) 39:489–496
deVet HCW, Terwee CB, Mokkink LB et al (2011) Measurement in Medicine. University printing House, Cambridge, p 337
Davison SN, Koncicki H, Brennan F (2014) Pain in chronic kidney disease: a scoping review. Semin Dial 27:188–204
pubmed: 24517512
Chen LK, Woo J, Assantachai P et al (2020) Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment. J Am Med Dir Assoc 21:300–307
pubmed: 32033882
Walker SR, Brar R, Eng F et al (2015) Frailty and physical function in chronic kidney disease: the CanFIT study. Can J Kidney Health Dis 2:32
pubmed: 26346754
pmcid: 4560862
Lattanzio F, Corsonello A, Abbatecola AM et al (2012) Relationship between renal function and physical performance in elderly hospitalized patients. Rejuvenation Res 15:545–552
pubmed: 22950422
pmcid: 3549205
Vettoretti S, Caldiroli L, Porata G et al (2020) Frailty phenotype and multi-domain impairments in older patients with chronic kidney disease. BMC Geriatr 20:371
pubmed: 32993531
pmcid: 7523369
Park SK, Kim WJ, Lee SY et al (2020) Mild chronic kidney disease and its relation to functional disability in Korean elderly population. Int Urol Nephrol 52:1929–1934
pubmed: 32661624
Chang J, Hou WW, Wang YF et al (2020) Main risk factors related to activities of daily living in non-dialysis patients with chronic kidney disease stage 3–5: a case-control study. Clin Interv Aging 15:609–618
pubmed: 32431494
pmcid: 7200239
Moorthi RN, Latham-Mintus K (2019) Social isolation in chronic kidney disease and the role of mobility limitation. Clin Kidney J 12:602–610
pubmed: 31384455
pmcid: 6671555
Murphy EL, Murtagh FEM, Carey I et al (2009) Understanding symptoms in patients with advanced chronic kidney disease managed without dialysis: use of a short patient-completed assessment tool. Nephron Clin Pract 111:74–80
Voskamp PWM, van Diepen M, Evans M et al (2019) The impact of symptoms on health-related quality of life in elderly predialysis patients: effect and importance in the EQUAL study. Nephrol Dial Transpl 34:1707–1715
Tong A, Sainsbury P, Chadban S et al (2009) Patients’ experiences and perspectives of living with CKD. Am J Kidney Dis 53:689–700
pubmed: 19216015
Yamagata K, Hoshino J, Sugiyama H et al (2019) Clinical practice guideline for renal rehabilitation: systematic reviews and recommendations of exercise therapies in patients with kidney diseases. RRT 28:4–5
Ma DY, Chen CC, Diao YS et al (2020) Efficacy of exercises in improving the quality of life for chronic kidney disease patients without dialysis. Chin Med J 133:1738–1740
pubmed: 32649528
pmcid: 7401775
Nakamura K, Sasaki T, Yamamoto S et al (2020) Effects of exercise on kidney and physical function in patients with non-dialysis chronic kidney disease: a systematic review and meta-analysis. Sci Rep 10:18195
pubmed: 33097801
pmcid: 7585437
Salehi F, Dehghan M, Shahrbabaki PM et al (2020) Effectiveness of exercise on fatigue in hemodialysis patients: a randomized controlled trial. BMC Sports Sci Med Rehabil 12:19
pubmed: 32206314
pmcid: 7081561