Sodium thiosulfate acts as a hydrogen sulfide mimetic to prevent intimal hyperplasia via inhibition of tubulin polymerisation.

Animals Cell Proliferation Cystathionine gamma-Lyase / metabolism Humans Hydrogen Sulfide / metabolism Hyperplasia / pathology Male Mice Myocytes, Smooth Muscle / metabolism Thiosulfates Tubulin / metabolism
Hydrogen sulfide Intimal hyperplasia Proliferation Smooth muscle cells Sodium thiosulfate

Journal

EBioMedicine
ISSN: 2352-3964
Titre abrégé: EBioMedicine
Pays: Netherlands
ID NLM: 101647039

Informations de publication

Date de publication:
Apr 2022
Historique:
received: 09 08 2021
revised: 08 03 2022
accepted: 08 03 2022
pubmed: 26 3 2022
medline: 27 4 2022
entrez: 25 3 2022
Statut: ppublish

Résumé

Intimal hyperplasia (IH) remains a major limitation in the long-term success of any type of revascularisation. IH is due to vascular smooth muscle cell (VSMC) dedifferentiation, proliferation and migration. The gasotransmitter Hydrogen Sulfide (H Low density lipoprotein receptor deleted (LDLR STS inhibited IH in WT mice, as well as in LDLR STS, a drug used for the treatment of cyanide poisoning and calciphylaxis, protects against IH in a mouse model of arterial restenosis and in human vein segments. STS acts as an H This work was supported by the Swiss National Science Foundation (grant FN-310030_176158 to FA and SD and PZ00P3-185927 to AL); the Novartis Foundation to FA; and the Union des Sociétés Suisses des Maladies Vasculaires to SD, and the Fondation pour la recherche en chirurgie vasculaire et thoracique.

Sections du résumé

BACKGROUND BACKGROUND
Intimal hyperplasia (IH) remains a major limitation in the long-term success of any type of revascularisation. IH is due to vascular smooth muscle cell (VSMC) dedifferentiation, proliferation and migration. The gasotransmitter Hydrogen Sulfide (H
METHODS METHODS
Low density lipoprotein receptor deleted (LDLR
FINDINGS RESULTS
STS inhibited IH in WT mice, as well as in LDLR
INTERPRETATION CONCLUSIONS
STS, a drug used for the treatment of cyanide poisoning and calciphylaxis, protects against IH in a mouse model of arterial restenosis and in human vein segments. STS acts as an H
FUNDING BACKGROUND
This work was supported by the Swiss National Science Foundation (grant FN-310030_176158 to FA and SD and PZ00P3-185927 to AL); the Novartis Foundation to FA; and the Union des Sociétés Suisses des Maladies Vasculaires to SD, and the Fondation pour la recherche en chirurgie vasculaire et thoracique.

Identifiants

DOI: 10.1016/j.ebiom.2022.103954 PMID: 35334307 PMC: PMC8941337
pubmed: 35334307
pii: S2352-3964(22)00138-4
doi: 10.1016/j.ebiom.2022.103954
pmc: PMC8941337
pii:
doi:

Substances chimiques

Thiosulfates 0
Tubulin 0
Cystathionine gamma-Lyase EC 4.4.1.1
sodium thiosulfate HX1032V43M
Hydrogen Sulfide YY9FVM7NSN

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

103954

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Diane Macabrey (D)

Department of Vascular Surgery, Lausanne University Hospital, Switzerland; CHUV-Service de chirurgie vasculaire, Department of Biomedical Sciences, University of Lausanne, Bugnon 7A, Lausanne 1005, Switzerland.

Alban Longchamp (A)

Department of Vascular Surgery, Lausanne University Hospital, Switzerland; CHUV-Service de chirurgie vasculaire, Department of Biomedical Sciences, University of Lausanne, Bugnon 7A, Lausanne 1005, Switzerland.

Michael R MacArthur (MR)

Department of Health Sciences and Technology, Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland.

Martine Lambelet (M)

Department of Vascular Surgery, Lausanne University Hospital, Switzerland; CHUV-Service de chirurgie vasculaire, Department of Biomedical Sciences, University of Lausanne, Bugnon 7A, Lausanne 1005, Switzerland.

Severine Urfer (S)

Department of Vascular Surgery, Lausanne University Hospital, Switzerland; CHUV-Service de chirurgie vasculaire, Department of Biomedical Sciences, University of Lausanne, Bugnon 7A, Lausanne 1005, Switzerland.

Sebastien Deglise (S)

Department of Vascular Surgery, Lausanne University Hospital, Switzerland; CHUV-Service de chirurgie vasculaire, Department of Biomedical Sciences, University of Lausanne, Bugnon 7A, Lausanne 1005, Switzerland.

Florent Allagnat (F)

Department of Vascular Surgery, Lausanne University Hospital, Switzerland; CHUV-Service de chirurgie vasculaire, Department of Biomedical Sciences, University of Lausanne, Bugnon 7A, Lausanne 1005, Switzerland. Electronic address: Florent.allagnat@chuv.ch.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Sodium thiosulfate acts as a hydrogen sulfide...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Sodium thiosulfate acts as a hydrogen sulfide...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Lyases › Carbon-sulfur lyases › Cystathionine gamma-lyase › Sodium thiosulfate acts as a hydrogen sulfide...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Sodium thiosulfate acts as a hydrogen sulfide...
questionsmedicales.fr › Produits chimiques inorganiques › Sulfure d'hydrogène › Sodium thiosulfate acts as a hydrogen sulfide...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Hyperplasie › Sodium thiosulfate acts as a hydrogen sulfide...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Sodium thiosulfate acts as a hydrogen sulfide...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes du muscle lisse › Sodium thiosulfate acts as a hydrogen sulfide...
questionsmedicales.fr › Produits chimiques inorganiques › Sulfates › Thiosulfates › Sodium thiosulfate acts as a hydrogen sulfide...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Tubuline › Sodium thiosulfate acts as a hydrogen sulfide...