Mitigating Benzodiazepine Dependence and the Risk of Drug-Induced QTc Prolongation in the Treatment of Gastroparesis: A Case Report.
QTc prolongation
benzodiazepine dependence
gastroparesis
medication safety
pharmacist
Journal
Medicina (Kaunas, Lithuania)
ISSN: 1648-9144
Titre abrégé: Medicina (Kaunas)
Pays: Switzerland
ID NLM: 9425208
Informations de publication
Date de publication:
10 Mar 2022
10 Mar 2022
Historique:
received:
13
12
2021
revised:
24
01
2022
accepted:
02
03
2022
entrez:
26
3
2022
pubmed:
27
3
2022
medline:
31
3
2022
Statut:
epublish
Résumé
Patients are often faced with challenges when it comes to safe therapeutic options. An 89-year-old female with a history of arrhythmias and refractory gastroparesis complained of adverse drug events from her benzodiazepine. While performing a comprehensive medication review and a medication safety review using an advanced clinical decision support system, the pharmacist successfully tapered off the benzodiazepine to a safer alternative antidepressant indicated for the treatment of gastroparesis. Special attention was given to selecting drugs with less QT prolongation risk, based on her age, current drug regimen, previous medical history, and presence of polypharmacy.
Identifiants
pubmed: 35334585
pii: medicina58030409
doi: 10.3390/medicina58030409
pmc: PMC8951483
pii:
doi:
Substances chimiques
Benzodiazepines
12794-10-4
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
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