Modified Hemagglutination Tests for COVID-19 Serology in Resource-Poor Settings: Ready for Prime-Time?

COVID-19 SARS-CoV-2 Spike hemagglutination tests serology

Journal

Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355

Informations de publication

Date de publication:
08 Mar 2022
Historique:
received: 24 01 2022
revised: 01 03 2022
accepted: 07 03 2022
entrez: 26 3 2022
pubmed: 27 3 2022
medline: 27 3 2022
Statut: epublish

Résumé

During the ongoing COVID-19 pandemic, serology has suffered several manufacturing and budget bottlenecks. Kode technology exposes exogenous antigens on the surface of cells; in the case of red blood cells, modified cells are called kodecytes, making antibody-antigen reactions detectable by the old-fashioned hemagglutination test. In this commentary, we review evidence supporting the utility of SARS-CoV-2 Spike kodecytes for clinical diagnostic purposes and serosurveys in resource-poor settings.

Identifiants

pubmed: 35335038
pii: vaccines10030406
doi: 10.3390/vaccines10030406
pmc: PMC8953758
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Daniele Focosi (D)

North-Western Tuscany Blood Bank, Pisa University Hospital, 56124 Pisa, Italy.

Massimo Franchini (M)

Division of Transfusion Medicine, Carlo Poma Hospital, 46100 Mantua, Italy.

Fabrizio Maggi (F)

Department of Medicine and Surgery, University of Insubria, 21100 Varese, Italy.

Classifications MeSH