Synthesis and Investigation of Flavanone Derivatives as Potential New Anti-Inflammatory Agents.
RAW264.7
anti-inflammatory activity
flavanone
pinocembrin
structure–activity relationship (SAR)
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
09 Mar 2022
09 Mar 2022
Historique:
received:
31
01
2022
revised:
28
02
2022
accepted:
02
03
2022
entrez:
26
3
2022
pubmed:
27
3
2022
medline:
31
3
2022
Statut:
epublish
Résumé
Flavonoids are polyphenols with broad known pharmacological properties. A series of 2,3-dihydroflavanone derivatives were thus synthesized and investigated for their anti-inflammatory activities. The target flavanones were prepared through cyclization of 2'-hydroxychalcone derivatives, the later obtained by Claisen-Schmidt condensation. Since nitric oxide (NO) represents an important inflammatory mediator, the effects of various flavanones on the NO production in the LPS-induced RAW 264.7 macrophage were assessed in vitro using the Griess test. The most active compounds were flavanone (
Identifiants
pubmed: 35335145
pii: molecules27061781
doi: 10.3390/molecules27061781
pmc: PMC8953636
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Flavanones
0
Nitric Oxide
31C4KY9ESH
flavanone
WX22P730FB
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fondation Université de la Nouvelle-Calédonie
ID : NORAS
Organisme : Gouvernement de la Nouvelle-Calédonie
ID : scholarships Cynthia Sinyeue
Références
Phytother Res. 2020 Dec;34(12):3137-3147
pubmed: 32613637
Biochem Pharmacol. 1999 Sep 1;58(5):759-65
pubmed: 10449184
Bioorg Med Chem. 2009 Dec 1;17(23):8073-85
pubmed: 19853459
Br J Pharmacol. 1993 Oct;110(2):701-6
pubmed: 8242242
Mol Nutr Food Res. 2018 Jan;62(1):
pubmed: 29108107
Adv Drug Deliv Rev. 2001 Mar 1;46(1-3):3-26
pubmed: 11259830
J Med Chem. 2008 Mar 27;51(6):1874-84
pubmed: 18307286
Biochem Pharmacol. 1997 Mar 21;53(6):897-903
pubmed: 9113109
In Vivo. 2005 Sep-Oct;19(5):895-909
pubmed: 16097445
Molecules. 2019 Jun 24;24(12):
pubmed: 31238565
Org Biomol Chem. 2016 Aug 21;14(31):7392-442
pubmed: 27381273
Bioorg Med Chem Lett. 2011 Oct 15;21(20):6036-41
pubmed: 21907578
J Agric Food Chem. 2017 Oct 11;65(40):8884-8891
pubmed: 28925259
Int Immunopharmacol. 2012 Sep;14(1):66-74
pubmed: 22713932
Bioorg Med Chem Lett. 2010 Sep 15;20(18):5466-8
pubmed: 20708932
J Ethnopharmacol. 2009 Jun 25;123(3):369-77
pubmed: 19501268
Nat Prod Res. 2019 Jan;33(2):162-168
pubmed: 29463111
Arch Pharm Res. 1998 Aug;21(4):481-4
pubmed: 9875481
Biochemistry. 2012 Aug 7;51(31):6097-107
pubmed: 22794353
Food Chem. 2019 Nov 30;299:125124
pubmed: 31288163
Int J Cancer. 2018 May 1;142(9):1748-1758
pubmed: 29210053
Bioorg Med Chem. 2006 Mar 1;14(5):1538-45
pubmed: 16386424
Br J Rheumatol. 1998 Mar;37(3):246-57
pubmed: 9566663
Med Res Rev. 2009 Sep;29(5):767-820
pubmed: 19378317
Int Immunopharmacol. 2021 Jan;90:107230
pubmed: 33290968
Bioorg Med Chem. 2017 Mar 15;25(6):1817-1829
pubmed: 28214231
BMC Complement Altern Med. 2016 Nov 15;16(1):467
pubmed: 27846826
J Nat Prod. 2000 Jul;63(7):1035-42
pubmed: 10924197
Cytotechnology. 2000 Jan;32(1):63-75
pubmed: 19002967
Langmuir. 2015 Mar 31;31(12):3635-43
pubmed: 25768724