Anti-Inflammatory Activity of Bryophytes Extracts in LPS-Stimulated RAW264.7 Murine Macrophages.
Dicranum majus
Thuidium delicatulum
anti-inflammatory activity
bryophytes
mosses
nitric oxide
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
17 Mar 2022
17 Mar 2022
Historique:
received:
13
02
2022
revised:
26
02
2022
accepted:
12
03
2022
entrez:
26
3
2022
pubmed:
27
3
2022
medline:
31
3
2022
Statut:
epublish
Résumé
Bryophytes produce rare and bioactive compounds with a broad range of therapeutic potential, and many species are reported in ethnomedicinal uses. However, only a few studies have investigated their potential as natural anti-inflammatory drug candidate compounds. The present study investigates the anti-inflammatory effects of thirty-two species of bryophytes, including mosses and liverworts, on Raw 264.7 murine macrophages stimulated with lipopolysaccharide (LPS) or recombinant human peroxiredoxin (hPrx1). The 70% ethanol extracts of bryophytes were screened for their potential to reduce the production of nitric oxide (NO), an important pro-inflammatory mediator. Among the analyzed extracts, two moss species significantly inhibited LPS-induced NO production without cytotoxic effects. The bioactive extracts of
Identifiants
pubmed: 35335304
pii: molecules27061940
doi: 10.3390/molecules27061940
pmc: PMC8953629
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Lipopolysaccharides
0
Plant Extracts
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Union
ID : 765115
Organisme : Agence Nationale de la Recherche
ID : Lorraine université d'excellence
Organisme : Région Grand Est
ID : FRCR
Références
Plants (Basel). 2021 Jan 21;10(2):
pubmed: 33494524
Nat Med. 2012 Jun;18(6):911-7
pubmed: 22610280
Nat Rev Immunol. 2020 Feb;20(2):95-112
pubmed: 31558839
Nature. 2008 Jul 24;454(7203):428-35
pubmed: 18650913
Trends Immunol. 2015 Mar;36(3):161-78
pubmed: 25687683
PLoS One. 2016 Oct 7;11(10):e0164586
pubmed: 27716839
Cell Chem Biol. 2018 May 17;25(5):550-559.e3
pubmed: 29551349
ACS Catal. 2020 Mar 6;10(5):3326-3339
pubmed: 32363077
Ecol Evol. 2018 Aug 22;8(17):9105-9117
pubmed: 30271570
Int Immunopharmacol. 2016 Dec;41:82-89
pubmed: 27821296
Prog Lipid Res. 2006 Jul;45(4):334-56
pubmed: 16678271
Int Immunopharmacol. 2018 Jul;60:141-151
pubmed: 29730557
Nat Rev Immunol. 2014 May;14(5):289-301
pubmed: 24722477
Front Immunol. 2018 Oct 16;9:2379
pubmed: 30459758
Front Immunol. 2019 Jul 03;10:1462
pubmed: 31333642
J Tradit Complement Med. 2016 Apr 04;7(1):94-98
pubmed: 28053893
Mol Cells. 2016 Jan;39(1):60-4
pubmed: 26813661
Int J Nanomedicine. 2019 Apr 26;14:2945-2959
pubmed: 31114201
Phytomedicine. 2019 Jun;59:152789
pubmed: 31009851
Annu Rev Pathol. 2020 Jan 24;15:493-518
pubmed: 31675482
Plants (Basel). 2021 Jun 22;10(7):
pubmed: 34206653
Free Radic Biol Med. 2015 Nov;88(Pt B):189-198
pubmed: 25968070
Future Sci OA. 2015;1(1):
pubmed: 26634146
J Ethnopharmacol. 2021 Nov 15;280:114452
pubmed: 34311061
Int J Mol Med. 2014 Oct;34(4):1101-9
pubmed: 25109657
J Nat Prod. 1993 Jul;56(7):1071-7
pubmed: 8377015