Performance of Five Metagenomic Classifiers for Virus Pathogen Detection Using Respiratory Samples from a Clinical Cohort.

bioinformatics next-generation sequencing pathogen detection viral metagenomics

Journal

Pathogens (Basel, Switzerland)
ISSN: 2076-0817
Titre abrégé: Pathogens
Pays: Switzerland
ID NLM: 101596317

Informations de publication

Date de publication:
11 Mar 2022
Historique:
received: 21 01 2022
revised: 21 02 2022
accepted: 07 03 2022
entrez: 26 3 2022
pubmed: 27 3 2022
medline: 27 3 2022
Statut: epublish

Résumé

Viral metagenomics is increasingly applied in clinical diagnostic settings for detection of pathogenic viruses. While several benchmarking studies have been published on the use of metagenomic classifiers for abundance and diversity profiling of bacterial populations, studies on the comparative performance of the classifiers for virus pathogen detection are scarce. In this study, metagenomic data sets (

Identifiants

pubmed: 35335664
pii: pathogens11030340
doi: 10.3390/pathogens11030340
pmc: PMC8953373
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Ellen C Carbo (EC)

Department of Medical Microbiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

Igor A Sidorov (IA)

Department of Medical Microbiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

Anneloes L van Rijn-Klink (AL)

Department of Medical Microbiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

Nikos Pappas (N)

Sequencing Analysis Support Core, Department of Biomedical Data Sciences, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Theoretical Biology and Bioinformatics, Department of Biology, Science for Life, Utrecht University, 3584 CH Utrecht, The Netherlands.

Sander van Boheemen (S)

Department of Medical Microbiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Department of Viroscience, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands.

Hailiang Mei (H)

Sequencing Analysis Support Core, Department of Biomedical Data Sciences, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

Pieter S Hiemstra (PS)

Department of Pulmonology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

Tomas M Eagan (TM)

Department of Thoracic Medicine, Haukeland University Hospital, 5021 Bergen, Norway.

Eric C J Claas (ECJ)

Department of Medical Microbiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

Aloys C M Kroes (ACM)

Department of Medical Microbiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

Jutte J C de Vries (JJC)

Department of Medical Microbiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

Classifications MeSH