Development and Structural Analysis of Antibody Therapeutics for Filoviruses.
X-ray crystallography
antibody therapeutic
cryo-EM
ebolavirus
filovirus
marburgvirus
structural biology
Journal
Pathogens (Basel, Switzerland)
ISSN: 2076-0817
Titre abrégé: Pathogens
Pays: Switzerland
ID NLM: 101596317
Informations de publication
Date de publication:
18 Mar 2022
18 Mar 2022
Historique:
received:
22
02
2022
revised:
16
03
2022
accepted:
17
03
2022
entrez:
26
3
2022
pubmed:
27
3
2022
medline:
27
3
2022
Statut:
epublish
Résumé
The filoviruses, including ebolaviruses and marburgviruses, are among the world's deadliest pathogens. As the only surface-exposed protein on mature virions, their glycoprotein GP is the focus of current therapeutic monoclonal antibody discovery efforts. With recent technological developments, potent antibodies have been identified from immunized animals and human survivors of virus infections and have been characterized functionally and structurally. Structural insight into how the most successful antibodies target GP further guides vaccine development. Here we review the recent developments in the identification and characterization of neutralizing antibodies and cocktail immunotherapies.
Identifiants
pubmed: 35335698
pii: pathogens11030374
doi: 10.3390/pathogens11030374
pmc: PMC8949092
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI132204
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI142790
Pays : United States
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