Programmed Cell Death Alterations Mediated by Synthetic Indole Chalcone Resulted in Cell Cycle Arrest, DNA Damage, Apoptosis and Signaling Pathway Modulations in Breast Cancer Model.
antiproliferative
apoptosis
autophagy
breast cancer
chalcones
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
24 Feb 2022
24 Feb 2022
Historique:
received:
27
12
2021
revised:
18
02
2022
accepted:
22
02
2022
entrez:
26
3
2022
pubmed:
27
3
2022
medline:
27
3
2022
Statut:
epublish
Résumé
Although new chemotherapy significantly increased the survival of breast cancer (BC) patients, the use of these drugs is often associated with serious toxicity. The discovery of novel anticancer agents for BC therapy is expected. This study was conducted to explore the antiproliferative effect of newly synthesized indole chalcone derivative ZK-CH-11d on human BC cell lines. MTT screening, flow cytometry, Western blot, and fluorescence microscopy were used to evaluate the mode of cell death. ZK-CH-11d significantly suppressed the proliferation of BC cells with minimal effect against non-cancer cells. This effect was associated with cell cycle arrest at the G2/M phase and apoptosis induction. Apoptosis was associated with cytochrome
Identifiants
pubmed: 35335879
pii: pharmaceutics14030503
doi: 10.3390/pharmaceutics14030503
pmc: PMC8953149
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Slovak Research and Development Agency
ID : APVV-16-0446
Organisme : The Ministry of Education, Science, Research and Sport of the Slovak Republic
ID : VEGA 1/0653/19
Organisme : The Ministry of Education, Science, Research and Sport of the Slovak Republic
ID : VEGA 1/0539/21
Organisme : Operational program Integrated Infrastructure by ERDF
ID : Drive4SIFood 313011V336
Organisme : Operational program Integrated Infrastructure by ERDF
ID : OPENMED ITMS2014+: 313011V455
Organisme : Internal scientific grant system of the Pavel Jozef Šafárik University in Košice
ID : VVGS grant 2020-1666
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