Poly ε-Caprolactone Nanoparticles for Sustained Intra-Articular Immune Modulation in Adjuvant-Induced Arthritis Rodent Model.
adjuvant induced arthritis
drug delivery
intra-articular drug delivery
leflunomide
nanotherapeutics
poly-ε-caprolactone
polymeric nanoparticle
rheumatoid arthritis
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
26 Feb 2022
26 Feb 2022
Historique:
received:
03
02
2022
revised:
20
02
2022
accepted:
22
02
2022
entrez:
26
3
2022
pubmed:
27
3
2022
medline:
27
3
2022
Statut:
epublish
Résumé
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder with synovitis and articular pathology as its primary expositions. Leflunomide (Lfd) is an anti-rheumatic drug that is effective in the treatment of RA, but displays severe side effects upon prolonged systemic administration. Local therapy might represent a promising strategy to treat rheumatoid arthritis without eliciting systemic adverse effects. In this study, leflunomide-loaded poly(ε-caprolactone) nanoparticles (Lfd-NPs) were prepared and assessed as a local drug delivery system capable of alleviating RA-associated inflammation. Lfd-NPs were optimized using the Quality by Design (QbD) approach, applying a 3
Identifiants
pubmed: 35335895
pii: pharmaceutics14030519
doi: 10.3390/pharmaceutics14030519
pmc: PMC8953799
pii:
doi:
Types de publication
Journal Article
Langues
eng
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