PLA
colonic brush border membrane vesicles
cyclosporine
drug targeting
inflammatory bowel disease
oral drug delivery
phospholipase A2
prodrug
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
18 Mar 2022
18 Mar 2022
Historique:
received:
13
02
2022
revised:
13
03
2022
accepted:
15
03
2022
entrez:
26
3
2022
pubmed:
27
3
2022
medline:
27
3
2022
Statut:
epublish
Résumé
Oral medication with activity specifically at the inflamed sites throughout the gastrointestinal tract and limited systemic exposure would be a major advance in our therapeutic approach to inflammatory bowel disease (IBD). For this purpose, we have designed a prodrug by linking active drug moiety to phospholipid (PL), the substrate of phospholipase A
Identifiants
pubmed: 35336048
pii: pharmaceutics14030675
doi: 10.3390/pharmaceutics14030675
pmc: PMC8950246
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : United States-Israel Binational Science Foundation
ID : 2015365
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