The Effect of Lithium on the Budding Yeast
lithium
long-term survival
macromolecular crowding
osmotic stress
protein aggregation
yeast
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
09 Mar 2022
09 Mar 2022
Historique:
received:
17
12
2021
revised:
02
03
2022
accepted:
07
03
2022
entrez:
26
3
2022
pubmed:
27
3
2022
medline:
27
3
2022
Statut:
epublish
Résumé
Lithium salts are used in the treatment of mood disorders, cancer, and Alzheimer's disease. It has been shown to prolong life span in several phyla; however, not yet in budding yeast. In our study, we investigate the influence of lithium on yeast cells' viability by characterizing protein aggregate formation, cell volume, and molecular crowding in the context of stress adaptation. While our data suggest a concentration-dependent growth inhibition caused by LiCl, we show an extended long-term survival rate as an effect of lithium addition upon glucose deprivation. We show that caloric restriction mitigates the negative impact of LiCl on cellular survival. Therefore, we suggest that lithium could affect glucose metabolism upon caloric restriction, which could explain the extended long-term survival observed in our study. We find furthermore that lithium chloride did not affect an immediate salt-induced Hsp104-dependent aggregate formation but cellular adaptation to H
Identifiants
pubmed: 35336166
pii: microorganisms10030590
doi: 10.3390/microorganisms10030590
pmc: PMC8953283
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Swedish Research Council
ID : VR2017-05117
Organisme : The Leverhulme Trust
ID : RPG-2019-156
Organisme : Wellcome Trust
ID : 204636/Z/16/Z
Pays : United Kingdom
Organisme : BBSRC
ID : BB/R001235/1
Organisme : The European Union's Horizon 2020
ID : 764591
Organisme : Swedish Foundation for Strategic Research
ID : FFL15-0238
Organisme : Wellcome Trust and the Royal Society
ID : 204636/Z/16/Z
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