Flavonoids Target Human Herpesviruses That Infect the Nervous System: Mechanisms of Action and Therapeutic Insights.
Epstein–Barr virus
HSV-1
HSV-2
Kaposi sarcoma-associated herpesvirus
flavonoids
herpes simplex virus
human cytomegalovirus
mechanisms of action
nervous system
neurological diseases
varicella-zoster virus
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
13 03 2022
13 03 2022
Historique:
received:
30
12
2021
revised:
08
03
2022
accepted:
11
03
2022
entrez:
26
3
2022
pubmed:
27
3
2022
medline:
15
4
2022
Statut:
epublish
Résumé
Human herpesviruses (HHVs) are large DNA viruses with highly infectious characteristics. HHVs can induce lytic and latent infections in their host, and most of these viruses are neurotropic, with the capacity to generate severe and chronic neurological diseases of the peripheral nervous system (PNS) and central nervous system (CNS). Treatment of HHV infections based on strategies that include natural products-derived drugs is one of the most rapidly developing fields of modern medicine. Therefore, in this paper, we lend insights into the recent advances that have been achieved during the past five years in utilizing flavonoids as promising natural drugs for the treatment of HHVs infections of the nervous system such as alpha-herpesviruses (herpes simplex virus type 1, type 2, and varicella-zoster virus), beta-herpesviruses (human cytomegalovirus), and gamma-herpesviruses (Epstein-Barr virus and Kaposi sarcoma-associated herpesvirus). The neurological complications associated with infections induced by the reviewed herpesviruses are emphasized. Additionally, this work covers all possible mechanisms and pathways by which flavonoids induce promising therapeutic actions against the above-mentioned herpesviruses.
Identifiants
pubmed: 35336999
pii: v14030592
doi: 10.3390/v14030592
pmc: PMC8949561
pii:
doi:
Substances chimiques
Flavonoids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Molecules. 2020 May 20;25(10):
pubmed: 32443914
Chem Biodivers. 2020 Feb;17(2):e1900511
pubmed: 31800173
Pathogens. 2021 Mar 15;10(3):
pubmed: 33804183
AJR Am J Roentgenol. 2016 Jan;206(1):39-48
pubmed: 26700334
J Nutr Biochem. 2017 Aug;46:1-12
pubmed: 28182964
Trends Microbiol. 2017 Mar;25(3):229-241
pubmed: 27956142
Semin Cell Dev Biol. 2017 Jul;67:91-100
pubmed: 28456604
J Virol. 2016 May 27;90(12):5534-5537
pubmed: 27053547
J Evid Based Integr Med. 2018 Jan-Dec;23:2515690X18806269
pubmed: 30362389
Int J Mol Sci. 2017 Dec 21;19(1):
pubmed: 29267216
J Neurovirol. 2021 Oct;27(5):774-781
pubmed: 34546546
Drug Discov Today Dis Models. 2020 Fall;32(Pt A):35-52
pubmed: 33897799
Viruses. 2019 May 22;11(5):
pubmed: 31121928
J Infect Dis. 2017 Jun 15;215(12):1898-1907
pubmed: 27932611
Clin Ther. 2018 Aug;40(8):1282-1298
pubmed: 30104016
PLoS Pathog. 2014 Jan;10(1):e1003882
pubmed: 24453974
Drug Discov Today. 2022 Jan;27(1):185-195
pubmed: 34678489
BMC Complement Med Ther. 2020 Apr 15;20(1):113
pubmed: 32295580
EXCLI J. 2019 Nov 05;18:1037-1048
pubmed: 31762727
Viruses. 2021 Mar 15;13(3):
pubmed: 33804210
Sci Rep. 2021 Jul 19;11(1):14696
pubmed: 34282252
J AOAC Int. 2019 Sep 1;102(5):1397-1400
pubmed: 31200785
Int J Mol Sci. 2021 Jul 13;22(14):
pubmed: 34299120
Viruses. 2021 May 28;13(6):
pubmed: 34071559
PLoS Pathog. 2020 Jul 23;16(7):e1008604
pubmed: 32702029
Int J Infect Dis. 2022 Jan;114:124-127
pubmed: 34718158
J Nat Prod. 2017 Nov 22;80(11):3010-3013
pubmed: 29099182
Semin Neurol. 2019 Jun;39(3):369-382
pubmed: 31378872
Clin Lab. 2021 Jul 1;67(7):
pubmed: 34258967
J Immunol Res. 2018 Nov 14;2018:7862782
pubmed: 30809554
Viruses. 2021 Oct 07;13(10):
pubmed: 34696448
Viruses. 2021 Oct 14;13(10):
pubmed: 34696502
Molecules. 2017 Apr 30;22(5):
pubmed: 28468298
J Immunol Res. 2018 Apr 12;2018:1264074
pubmed: 29850614
Lancet. 1964 Mar 28;1(7335):702-3
pubmed: 14107961
Curr Opin Virol. 2020 Oct;44:81-89
pubmed: 32777757
Adv Virus Res. 2019;104:313-343
pubmed: 31439152
Med Microbiol Immunol. 2019 Aug;208(3-4):495-512
pubmed: 30805724
ScientificWorldJournal. 2013 Dec 29;2013:162750
pubmed: 24470791
Epidemiology. 2018 Jul;29(4):571-573
pubmed: 29634591
J Virol. 2009 Sep;83(18):9554-66
pubmed: 19587049
J Mol Biol. 2022 Mar 30;434(6):167214
pubmed: 34437888
Recent Pat Inflamm Allergy Drug Discov. 2019;13(2):84-104
pubmed: 31814545
Virologie (Montrouge). 2020 Oct 1;24(5):283-294
pubmed: 33111702
J Ethnopharmacol. 2020 Feb 10;248:112296
pubmed: 31610262
J Gen Virol. 2021 Nov;102(11):
pubmed: 34747688
Viruses. 2018 Nov 02;10(11):
pubmed: 30400213
Virulence. 2021 Dec;12(1):2670-2702
pubmed: 34676800
Biotechnol Appl Biochem. 2021 Sep 29;:
pubmed: 34586691
Viruses. 2018 Nov 07;10(11):
pubmed: 30405048
J Pathol. 2015 Jan;235(2):288-97
pubmed: 25205255
Food Chem Toxicol. 2019 Oct;132:110646
pubmed: 31252025
Am J Chin Med. 2021;49(1):163-179
pubmed: 33371809
Antiviral Res. 2017 Dec;148:15-19
pubmed: 28965916
Microbiol Immunol. 2018 May;62(5):341-347
pubmed: 29603339
Mater Sci Eng C Mater Biol Appl. 2017 Jun 1;75:1214-1220
pubmed: 28415409
Phytother Res. 2019 Sep;33(9):2221-2243
pubmed: 31359516
Antiviral Res. 2020 May;177:104714
pubmed: 32165083
Pediatr Neurol. 2020 Apr;105:10-20
pubmed: 31932119
FEBS Open Bio. 2018 Feb 20;8(4):646-654
pubmed: 29632816
Adv Anat Embryol Cell Biol. 2017;223:1-27
pubmed: 28528437
Nat Rev Dis Primers. 2015 Jul 02;1:15016
pubmed: 27188665
Cell Immunol. 2019 Feb;336:58-65
pubmed: 30626494
Virol J. 2021 Aug 6;18(1):162
pubmed: 34362398
J Neurovirol. 2020 Oct;26(5):696-703
pubmed: 32696182
Front Cell Infect Microbiol. 2021 Mar 15;11:647992
pubmed: 33791247
Microorganisms. 2021 Jan 31;9(2):
pubmed: 33572685
Molecules. 2017 Oct 11;22(10):
pubmed: 29019930
Int J Infect Dis. 2019 May;82:106-110
pubmed: 30844517
Virus Res. 2018 Apr 2;249:93-98
pubmed: 29604359
Adv Anat Embryol Cell Biol. 2017;223:95-117
pubmed: 28528441
Virology. 2020 Oct;549:85-88
pubmed: 32858308
Int J Dermatol. 2020 Oct;59(10):1202-1209
pubmed: 32346863
BMC Infect Dis. 2013 Dec 21;13:600
pubmed: 24359263
Handb Clin Neurol. 2014;123:307-18
pubmed: 25015492
Front Immunol. 2020 Dec 17;11:587078
pubmed: 33391262
J Formos Med Assoc. 2021 Dec;120(12):2136-2143
pubmed: 33390306
Curr Opin HIV AIDS. 2017 Jan;12(1):47-56
pubmed: 27662501
Chin Med J (Engl). 2019 Sep 5;132(17):2109-2118
pubmed: 31433331
J Neurol. 2022 Apr;269(4):1751-1757
pubmed: 34724572
Front Chem. 2021 Mar 31;9:637994
pubmed: 33869141
Nat Rev Microbiol. 2021 Dec;19(12):759-773
pubmed: 34168328
FEBS J. 2021 Sep 18;:
pubmed: 34536980
Virology. 2021 Jul;559:65-73
pubmed: 33836340
Oncol Res. 2021 Sep 7;28(7):763-778
pubmed: 33629943
Int J Pediatr Otorhinolaryngol. 2021 Sep;148:110809
pubmed: 34198225
J Virol. 2017 Nov 14;91(23):
pubmed: 28931686
J Pharm Pharmacol. 2015 Oct;67(10):1325-36
pubmed: 26060043
Arch Pharm (Weinheim). 2016 Jul;349(7):507-22
pubmed: 27244041
Front Cell Infect Microbiol. 2021 Mar 19;11:603309
pubmed: 33816328
J Leukoc Biol. 2013 Dec;94(6):1185-90
pubmed: 23812328
Viruses. 2020 Apr 23;12(4):
pubmed: 32340120
JACC Case Rep. 2021 Mar 17;3(3):455-458
pubmed: 34317557
Pathogens. 2020 Feb 15;9(2):
pubmed: 32075270
J Glob Antimicrob Resist. 2020 Dec;23:370-376
pubmed: 33161114
Vitam Horm. 2021;117:101-132
pubmed: 34420577
BMC Infect Dis. 2020 Nov 25;20(1):886
pubmed: 33238935
Molecules. 2021 Sep 04;26(17):
pubmed: 34500810
mBio. 2020 Oct 6;11(5):
pubmed: 33024035
Viruses. 2018 Jul 06;10(7):
pubmed: 29986399
Nutrients. 2021 Jan 19;13(1):
pubmed: 33477894
Int J Mol Sci. 2019 Dec 12;20(24):
pubmed: 31842358
Crit Rev Food Sci Nutr. 2019;59(13):2040-2051
pubmed: 29405736
Arch Virol. 2017 Sep;162(9):2539-2551
pubmed: 28547385
Molecules. 2019 Aug 11;24(16):
pubmed: 31405197
Viruses. 2020 Dec 01;12(12):
pubmed: 33271926
Nat Rev Immunol. 2011 Feb;11(2):143-54
pubmed: 21267015
J Nutr Sci. 2016 Dec 29;5:e47
pubmed: 28620474
Int J Mol Sci. 2021 Aug 11;22(16):
pubmed: 34445360
Biomed Pharmacother. 2021 Aug;140:111596
pubmed: 34126315
Planta Med. 2020 Mar;86(4):267-275
pubmed: 31968380
Adv Exp Med Biol. 2018;1045:85-102
pubmed: 29896664
mBio. 2015 Dec 01;6(6):e01844-15
pubmed: 26628726
Adv Anat Embryol Cell Biol. 2017;223:195-224
pubmed: 28528445
J Ethnopharmacol. 2020 Mar 25;250:112493
pubmed: 31863859
Joint Bone Spine. 2020 Mar;87(2):163-166
pubmed: 31669807
Annu Rev Virol. 2015 Nov;2(1):311-33
pubmed: 26958918
Cells. 2021 Aug 18;10(8):
pubmed: 34440891
J Virol. 2009 Jun;83(11):5904-17
pubmed: 19297489
Continuum (Minneap Minn). 2018 Oct;24(5, Neuroinfectious Disease):1349-1369
pubmed: 30273243
J Neuroimmunol. 2021 Sep 15;358:577636
pubmed: 34174587
Ceska Slov Farm. 2017 Summer;66(3):95-102
pubmed: 28914066
Microbiol Spectr. 2016 Jun;4(3):
pubmed: 27337443
Ann Neurol. 2002 Nov;52(5):543-8
pubmed: 12402250
Antiviral Res. 2018 Jun;154:10-16
pubmed: 29559264
J Exp Med. 1965 May 1;121:761-70
pubmed: 14278230
J Biomed Sci. 2017 Jan 5;24(1):2
pubmed: 28056971
Arch Pharm Res. 2017 May;40(5):623-630
pubmed: 28258480
Neurotherapeutics. 2016 Jul;13(3):509-13
pubmed: 27032406
Nat Rev Microbiol. 2021 Feb;19(2):110-121
pubmed: 33087881
Int J STD AIDS. 2022 Feb;33(2):212-214
pubmed: 34726092
Viruses. 2020 Jan 29;12(2):
pubmed: 32013134
Pharmacol Ther. 2019 Feb;194:107-131
pubmed: 30268770
Antiviral Res. 2017 Aug;144:273-280
pubmed: 28629987
Adv Exp Med Biol. 2017;1018:91-127
pubmed: 29052134
Adv Virus Res. 2006;66:337-94
pubmed: 16877064
Intern Med. 2003 Jan;42(1):33-40
pubmed: 12583615
J Neurovirol. 2010 Nov;16(6):411-8
pubmed: 20874010
Nat Rev Drug Discov. 2021 Mar;20(3):200-216
pubmed: 33510482
Front Microbiol. 2017 Jan 05;7:2129
pubmed: 28105027
EPMA J. 2021 May 17;12(2):155-176
pubmed: 34025826
BMC Microbiol. 2020 Jul 28;20(1):227
pubmed: 32723300
Elife. 2019 Aug 08;8:
pubmed: 31393262
Pediatr Rev. 2012 Apr;33(4):156-63; quiz 163
pubmed: 22474112
Nat Clin Pract Neurol. 2007 Feb;3(2):82-94
pubmed: 17279082
Toxicol Res. 2021 Jan 20;37(2):147-162
pubmed: 33868973