α-Glucosidase and Bacterial β-Glucuronidase Inhibitors from the Stems of
Schisandra sphaerandra
bacterial β-glucuronidase
diabetes
drug-induced diarrhea
triterpenoids
α-glucosidase
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
09 Mar 2022
09 Mar 2022
Historique:
received:
15
02
2022
revised:
05
03
2022
accepted:
07
03
2022
entrez:
26
3
2022
pubmed:
27
3
2022
medline:
27
3
2022
Statut:
epublish
Résumé
α-Glucosidase (AGS) is a therapeutic target for Type 2 diabetes mellitus (T2DM) that tends to complicate with other diseases. Some medications for the treatment of T2DM complications have the risk of inducing severe adverse reactions such as diarrhea via the metabolism of intestinal bacterial β-glucuronidase (BGUS). The development of new AGS and/or BGUS inhibitors may improve the therapeutic effects of T2DM and its complications. The present work focused on the isolation and characterization of AGS and/or BGUS inhibitors from the medicinal plant
Identifiants
pubmed: 35337127
pii: ph15030329
doi: 10.3390/ph15030329
pmc: PMC8954508
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Key Research & Development Program of China
ID : 2020YFF0424461
Organisme : Science and Technology Plan Project of Zhejiang Province
ID : LGF20H300010
Références
Chem Rev. 2005 Dec;105(12):4581-609
pubmed: 16351055
Chem Pharm Bull (Tokyo). 2003 Oct;51(10):1174-6
pubmed: 14519924
Diabetologia. 2018 Oct;61(10):2140-2154
pubmed: 30027404
J Nat Prod. 1996 May;59(5):525-7
pubmed: 8778243
Eur J Med Chem. 2018 Sep 5;157:1460-1479
pubmed: 30282319
Fitoterapia. 2012 Jul;83(5):926-31
pubmed: 22537642
Acta Crystallogr A Found Adv. 2015 Jan;71(Pt 1):3-8
pubmed: 25537383
Molecules. 2017 Feb 14;22(2):
pubmed: 28216594
Acta Crystallogr C Struct Chem. 2015 Jan;71(Pt 1):3-8
pubmed: 25567568
Acta Diabetol. 2010 Jun;47(2):87-95
pubmed: 20376506
J Natl Cancer Inst. 1997 May 7;89(9):660-1
pubmed: 9150194
J Nat Prod. 2017 May 26;80(5):1584-1593
pubmed: 28422509
Toxicol Appl Pharmacol. 2020 Jul 1;398:115032
pubmed: 32387182
Planta Med. 2006 Apr;72(5):450-7
pubmed: 16557460
Pharmacol Ther. 2019 Jul;199:1-15
pubmed: 30831128
Nat Prod Rep. 2008 Oct;25(5):871-91
pubmed: 18820756
Nat Rev Endocrinol. 2018 Feb;14(2):88-98
pubmed: 29219149
Org Lett. 2020 May 1;22(9):3377-3380
pubmed: 32285675
Phytochemistry. 2022 Apr;196:113106
pubmed: 35078105
Nat Prod Res. 2022 Jan;36(1):287-294
pubmed: 32538675
Phytochemistry. 2014 Dec;108:171-6
pubmed: 25446238
Zhongguo Zhong Yao Za Zhi. 2003 Feb;28(2):138-40
pubmed: 15015287
Science. 2010 Nov 5;330(6005):831-5
pubmed: 21051639
Drugs. 2005;65(3):385-411
pubmed: 15669880
Org Lett. 2011 Mar 18;13(6):1564-7
pubmed: 21348450
Diabetes Res Clin Pract. 2017 Jun;128:40-50
pubmed: 28437734
Nucleic Acids Res. 2003 Jul 1;31(13):3381-5
pubmed: 12824332
Chem Biodivers. 2017 Jan;14(1):
pubmed: 27582055
Nat Prod Rep. 2015 Mar;32(3):367-410
pubmed: 25483912
J Natl Cancer Inst. 1999 Mar 17;91(6):542-7
pubmed: 10088625
Nat Rev Immunol. 2011 Feb;11(2):98-107
pubmed: 21233852
J Pharm Pract. 2017 Oct;30(5):549-556
pubmed: 27194069
Phytomedicine. 2019 May;58:152876
pubmed: 30851579
Dis Colon Rectum. 2013 Nov;56(11):1304-19
pubmed: 24105007
Chin J Nat Med. 2019 Dec;17(12):970-981
pubmed: 31882053