Pain management with transdermal drug administration: A review.

Administration, Cutaneous Analgesics Analgesics, Opioid Humans Pain / chemically induced Pain Management Pharmaceutical Preparations
Analgesics Controlled release Local anesthetics Pain Transdermal route

Journal

International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127

Informations de publication

Date de publication:
25 Apr 2022
Historique:
received: 29 01 2022
revised: 08 03 2022
accepted: 19 03 2022
pubmed: 27 3 2022
medline: 14 4 2022
entrez: 26 3 2022
Statut: ppublish

Résumé

Pain management is an urgent issue to solve with complex mechanisms. Localized acute pain requires rapid and accurate delivery of drugs with less distribution in the blood circulation while chronic pain requires controlled release of drugs with long drug retention time. The transdermal route, a promising way with high patient compliance was known for painless delivery, long drug retention time, stable blood concentration, easily controlled dosage and release rate as well as the fewer side effects. This review presents transdermal route for pain management according to the different sites of action which drugs aim to reach, and illustrates different analgesic mechanisms, dosage forms, transdermal enhancements and clinical applications. In addition, the review concludes the difference of pain types and presents the future aims of pain management, thereby providing a reference for researches focusing on percutaneous analgesia.

Identifiants

DOI: 10.1016/j.ijpharm.2022.121696 PMID: 35337906
pubmed: 35337906
pii: S0378-5173(22)00251-4
doi: 10.1016/j.ijpharm.2022.121696
pii:
doi:

Substances chimiques

Analgesics 0
Analgesics, Opioid 0
Pharmaceutical Preparations 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

121696

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Auteurs

Weitong Hu (W)

Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

Qiong Bian (Q)

Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

Yanjun Zhou (Y)

Zhejiang Huanling Pharmaceutical Technology Company, Jinhua 321000, China.

Jianqing Gao (J)

Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Jiangsu Engineering Research Center for New-type External and Transdermal Preparations , Changzhou 213149, China; Jinhua Institute of Zhejiang University, Jinhua 321002, China. Electronic address: gaojianqing@zju.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie topique › Administration par voie cutanée › Pain management with transdermal drug...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Analgésiques › Pain management with transdermal drug...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Dépresseurs du système nerveux central › Stupéfiants › Analgésiques morphiniques › Pain management with transdermal drug...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Pain management with transdermal drug...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Douleur › Pain management with transdermal drug...
questionsmedicales.fr › Administration des services de santé › Gestion des soins aux patients › Prise en charge de la maladie › Gestion de la douleur › Pain management with transdermal drug...
questionsmedicales.fr › Préparations pharmaceutiques › Pain management with transdermal drug...