Integration of multiparameter flow cytometry score improves prognostic stratification provided by standard models in primary myelofibrosis.
Journal
American journal of hematology
ISSN: 1096-8652
Titre abrégé: Am J Hematol
Pays: United States
ID NLM: 7610369
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
revised:
18
03
2022
received:
17
02
2022
accepted:
21
03
2022
pubmed:
27
3
2022
medline:
16
6
2022
entrez:
26
3
2022
Statut:
ppublish
Résumé
Prognostic modeling in myelofibrosis (MF) has classically pursued the integration of informative clinical and hematological parameters to separate patients' categories with different outcomes. Modern stratification includes also genetic data from karyotype and mutations. However, some poorly standardized variables, as peripheral blood (PB) blast count by morphology, are still included. In this study, we used multiparameter flow cytometry (MFC) with the aim of improving performance of existing scores. We studied 363 MF patients with available MFC files for PB CD34+ cells count determination at diagnosis. We adapted Ogata score to MF context including 2 parameters: absolute CD34+ cells count (/μL) and granulocytes to lymphocytes SSC ratio. A score of 1 was attributed to above-threshold values of each parameter. Accordingly, patients were categorized as MFC
Identifiants
pubmed: 35338671
doi: 10.1002/ajh.26548
pmc: PMC9682857
doi:
Substances chimiques
Antigens, CD34
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
846-855Subventions
Organisme : Cancer Research UK
Pays : United Kingdom
Informations de copyright
© 2022 The Authors. American Journal of Hematology published by Wiley Periodicals LLC.
Références
Leukemia. 2013 Sep;27(9):1861-9
pubmed: 23619563
Am J Hematol. 2022 Jul;97(7):846-855
pubmed: 35338671
Blood. 2009 Mar 26;113(13):2895-901
pubmed: 18988864
Cytometry B Clin Cytom. 2010 May;78(3):154-68
pubmed: 20198685
Haematologica. 2009 Aug;94(8):1124-34
pubmed: 19546437
Leukemia. 2008 Feb;22(2):437-8
pubmed: 17728787
Blood. 2006 Aug 1;108(3):1037-44
pubmed: 16574954
Br J Haematol. 2021 Mar;192(6):1054-1063
pubmed: 33618432
Leukemia. 2017 Dec;31(12):2851-2852
pubmed: 28819279
J Hematother. 1996 Jun;5(3):213-26
pubmed: 8817388
Leukemia. 2014 Jul;28(7):1568-70
pubmed: 24569778
Leukemia. 2008 Mar;22(3):530-7
pubmed: 18094717
Blood Cancer J. 2017 Jul 21;7(7):e584
pubmed: 28731458
Blood. 2001 Dec 1;98(12):3249-55
pubmed: 11719361
Blood. 2017 Jun 15;129(24):3227-3236
pubmed: 28351937
J Clin Oncol. 2018 Jun 10;36(17):1769-1770
pubmed: 29708808
Leukemia. 2018 Jul;32(7):1631-1642
pubmed: 29654267
Am J Hematol. 2019 Aug;94(8):845-852
pubmed: 31056768
Blood. 2020 Jun 25;135(26):2375-2387
pubmed: 32299093
Am J Hematol. 2018 May;93(5):649-654
pubmed: 29388258
Leukemia. 2017 Dec;31(12):2726-2731
pubmed: 28561069
Cancers (Basel). 2020 Oct 30;12(11):
pubmed: 33143086
Blood. 2016 May 19;127(20):2391-405
pubmed: 27069254
Blood. 2016 May 19;127(20):2375-90
pubmed: 26980727
Leuk Res. 2018 Aug;71:75-81
pubmed: 30025279
Blood. 2009 Jul 30;114(5):937-51
pubmed: 19357394
J Clin Oncol. 2018 Feb 1;36(4):310-318
pubmed: 29226763
Am J Hematol. 2021 Jan;96(1):145-162
pubmed: 33197049